Results 41 to 50 of about 39,675 (281)

Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

Breast Cancer Research, 2018
Background The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive breast cancer, and factors that influence the abundance of ...
Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz, Nicola Aceto   +15 more
doaj   +1 more source

A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis)

Oncology Letters, 2016
Metastasis is the major cause of mortality in patients with malignancies; however, the mechanisms of tumor cell dissemination and metastasis formation are obscure. Circulating tumor cells (CTCs) are believed to be a critical step for distant metastasis and are associated with a poor patient prognosis.
Yupeng, Hong, Ziduo, Li, Qi, Zhang
openaire   +3 more sources

Endogenous light scattering as an optical signature of circulating tumor cell clusters. [PDF]

Biomed Opt Express, 2016
Circulating tumor cell clusters (CTCCs) are significantly more likely to form metastases than single tumor cells. We demonstrate the potential of backscatter-based flow cytometry (BSFC) to detect unique light scattering signatures of CTCCs in the blood of mice orthotopically implanted with breast cancer cells and treated with an anti-ADAM8 or a control
Lyons J, Polmear M, Mineva ND, Romagnoli M, Sonenshein GE, Georgakoudi I.   +5 more
europepmc   +3 more sources

A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation

Frontiers in Oncology, 2021
Metastasis is a multistep process in which cells must detach, migrate/invade local structures, intravasate, circulate, extravasate, and colonize. A full understanding of the complexity of this process has been limited by the lack of ability to study ...
Tyler A. Allen, Mark M. Cullen, Nathan Hawkey, Hiroyuki Mochizuki, Lan Nguyen, Elyse Schechter, Luke Borst, Jeffrey A. Yoder, Jennifer A. Freedman, Jennifer A. Freedman, Steven R. Patierno, Steven R. Patierno, Ke Cheng, Ke Cheng, William C. Eward, Jason A. Somarelli, Jason A. Somarelli   +16 more
doaj   +1 more source

Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells [PDF]

Cancer Research, 2015
Abstract Clusters of circulating tumor cells (CTC) exhibit more robust metastatic properties than single CTC. Thus, understanding the distinct behaviors of CTC clusters and how CTC clustering is regulated may offer new insights into how to limit metastasis.
Jin Woo, Choi, Jun Ki, Kim, Yun Jung, Yang, Pilhan, Kim, Kwon-Ha, Yoon, Seok Hyun, Yun   +5 more
openaire   +2 more sources

Cell-free DNA methylation-defined prognostic subgroups in small-cell lung cancer identified by leukocyte methylation subtraction

iScience, 2022
Summary: Small-cell lung cancer (SCLC) methylome is understudied. Here, we comprehensively profile SCLC using cell-free methylated DNA immunoprecipitation followed by sequencing (cfMeDIP-seq).
Sami Ul Haq, Sabine Schmid, Mansi K. Aparnathi, Katrina Hueniken, Luna Jia Zhan, Danielle Sacdalan, Janice J.N. Li, Nicholas Meti, Devalben Patel, Dangxiao Cheng, Vivek Philip, Ming S. Tsao, Michael Cabanero, Daniel de Carvalho, Geoffrey Liu, Scott V. Bratman, Benjamin H. Lok   +16 more
doaj   +1 more source

Size-based detection of sarcoma circulating tumor cells and cell clusters

Oncotarget, 2017
Metastatic disease is the most important factor in determining the survival of sarcoma patients. Since sarcoma metastasis is predominantly hematogenous, we hypothesized that detection and quantification of circulating tumor cells (CTCs) could reflect response to therapy and risk of metastatic relapse.
Hayashi, Masanori, Zhu, Peixuan, McCarty, Gregory, Meyer, Christian F., Pratilas, Christine A., Levin, Adam, Morris, Carol D., Albert, Catherine M., Jackson, Kyle W., Tang, Cha-Mei, Loeb, David M.   +10 more
openaire   +3 more sources

The functional and clinical roles of liquid biopsy in patient-derived models

Journal of Hematology & Oncology, 2023
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) and extracellular vesicles (EVs) in the patient's body fluid.
Ziqing Zhu, Erya Hu, Hong Shen, Jun Tan, Shan Zeng   +4 more
doaj   +1 more source

Identification of fibroblast-related genes based on single-cell and machine learning to predict the prognosis and endocrine metabolism of pancreatic cancer

Frontiers in Endocrinology, 2023
BackgroundSingle-cell sequencing technology has become an indispensable tool in tumor mechanism and heterogeneity studies. Pancreatic adenocarcinoma (PAAD) lacks early specific symptoms, and comprehensive bioinformatics analysis for PAAD contributes to ...
Yinghua Xu, Xionghuan Chen, Xionghuan Chen, Nan Liu, Zhong Chu, Qiang Wang   +5 more
doaj   +1 more source

Detection of circulating tumour cell clusters in human glioblastoma [PDF]

British Journal of Cancer, 2018
Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it is unclear whether multicellular CTC clusters are generated in this disease and whether they can bypass the physical hurdle of the blood-brain barrier.
Krol, Ilona, Castro-Giner, Francesc, Maurer, Martina, Gkountela, Sofia, Szczerba, Barbara, Scherrer, Ramona, Coleman, Niamh, Carreira, Suzanne, Bachmann, Felix, Anderson, Stephanie, Engelhardt, Marc, Lane, Heidi, Evans, Thomas Ronald Jeffrey, Plummer, Ruth, Kristeleit, Rebecca, Lopez, Juanita, Aceto, Nicola   +16 more
openaire   +6 more sources