Results 121 to 130 of about 6,225,689 (197)

Exosomes in Cancer: The Biology, Function, Diagnosis, and Therapy

MedComm, Volume 7, Issue 11, November 2026.
Tumor‐derived exosomes and nonmembranous extracellular nanoparticles (exomeres/supermeres) constitute a heterogeneous communication network that drives cancer progression. By shuttling functional biomolecules across tissue‐specific barriers, these nanoparticles orchestrate local microenvironmental remodeling, immune suppression, premetastatic niche ...
Jun Wu, Lei Wu, Kang Yang, Kang Xie, Tao Lu, Tiangxiang Huang, Dengfeng Wan, Tao Song, Longbo Zhang   +8 more
wiley   +1 more source

Additional file 4: of Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

, 2018
Figure S1. Circulating tumor cell (CTC) capture strategy. (a) Schematic drawing showing the size-based capturing principle of the Parsortix microfluidic device (left).
Viola Heinzelmann-Schwarz (390410), Barbara Szczerba (5997695), Walter Weber (5997716), Christoph Rochlitz (190083), Ramona Scherrer (5997704), Christian Kurzeder (5997713), Marcus Vetter (3422660), Alfred Zippelius (805066), Ilona Krol (5997701), Julia Landin (5997692), Cinzia Donato (5997698), Alexandra Malinovska (5997710), Sofia Gkountela (191896), Francesc Castro-Giner (5659600), Catharina Balmelli (5997707), Nicola Aceto (5997719)   +15 more
core   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

PAK2 promotes CTC cluster formation by phosphorylating E-cadherin to enhance cell-cell adhesion in breast cancer

Breast Cancer Research
Background Circulating tumor cell (CTC) clusters exhibit significantly greater metastatic potential than single CTCs and are associated with poorer overall survival in cancers.
Lihuang Guo, Jiancheng Li, Wenxing Zhu, Zhuo Wang, Youyou Huang, Zhengyang Sun, Yue Huang, Keqian Xu   +7 more
doaj   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Circulating Tumor Cells in Right- and Left-Sided Colorectal Cancer

, 2019
Molecular alterations are not randomly distributed in colorectal cancer (CRC), but rather clustered on the basis of primary tumor location underlying the importance of colorectal cancer sidedness.
Ann Zeuner, Silverio Tomao, Valentina Magri, Alessandra Emiliani, Angela Gradilone, Chiara Nicolazzo, Patrizia Seminara, Flavia Loreni, Francesca Belardinilli, Cristina Raimondi, Federica Francescangeli, Paola Gazzaniga   +11 more
core   +1 more source

Spot size reduction and minibeam creation in a proton PBS nozzle using multipole permanent magnets

Medical Physics, Volume 53, Issue 11, November 2026.
Abstract Background Smaller spot sizes in pencil beam scanning (PBS) nozzles are generally desired to allow more conformal treatments and to spare normal tissue and organs at risk. The production of small diameter proton beams, especially proton minibeams, is challenging because long drift spaces in standard PBS nozzles exacerbate effects of MCS and ...
Grant A. McAuley
wiley   +1 more source

Additional file 10: of Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

, 2018
Table S8. Complete blood counts in patients with single circulating tumor cells and circulating tumor cell clusters. The table shows complete blood counts in patients in whom only single circulating tumor cells (single CTC) or also clustered circulating ...
Viola Heinzelmann-Schwarz (390410), Barbara Szczerba (5997695), Walter Weber (5997716), Christoph Rochlitz (190083), Ramona Scherrer (5997704), Christian Kurzeder (5997713), Marcus Vetter (3422660), Alfred Zippelius (805066), Ilona Krol (5997701), Julia Landin (5997692), Cinzia Donato (5997698), Alexandra Malinovska (5997710), Sofia Gkountela (191896), Francesc Castro-Giner (5659600), Catharina Balmelli (5997707), Nicola Aceto (5997719)   +15 more
core   +1 more source

Hirudin suppresses hematogenous metastasis by targeting desmosome junction transition in circulating tumor cell clusters via HIF-1α–DSG2 signaling

Experimental and Molecular Medicine
s Circulating tumor cell (CTC) clusters, key in metastasis, rely on intercellular junctions for stability. However, the specific mechanisms governing intercellular connections within CTC clusters and the strategy targeting intercellular junctions to ...
Jueyao Zou, Junfeng Shi, Qiong Chen, Ziyan Zhu, Tongyao Hu, Zhengyu Zhang, Zhiqiang Pan, Fei Xu, Yong Zhu, Yuanyuan Wu, Yang Zhao, Aiyun Wang, Yin Lu, Yanhong Pan, Wenxing Chen   +14 more
doaj   +1 more source

Primary BPH Stromal Cell Cultures Exhibit Heightened Androgen‐Responsiveness

The Prostate, Volume 86, Issue 15, Page 1508-1517, November 2026.
ABSTRACT Background Benign prostatic hyperplasia (BPH) is the most common disease in aging males. BPH growth is androgen‐dependent, and it appears that androgens preferentially stimulate the growth of BPH as compared to normal prostate. The mechanism of preferential androgen stimulation of BPH growth is not clear.
Wei Chen, Fulu Dong, Mohammad Reza Askarpour, Laura E. Pascal, Rajiv Dhir, Uma Chandran, Bruce L. Jacobs, Donald B. DeFranco, Naoki Yoshimura, Zhou Wang   +9 more
wiley   +1 more source