Results 1 to 10 of about 486,247 (294)

Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma [PDF]

Analytical Cellular Pathology, 2018
Hemangiopericytoma (HPT) is a rare mesenchymal tumor of fibroblastic type and for its rarity is poorly studied. The most common sites of metastatic disease in patients with intracranial HPT are the bone, liver, and lung, suggestive for an hematogenous ...
Chiara Nicolazzo, Luciano Colangelo, Alessandro Corsi, Guido Carpino, Angela Gradilone, Chiara Sonato, Cristina Raimondi, Eugenio Gaudio, Paola Gazzaniga, Walter Gianni   +9 more
doaj   +4 more sources

Tumor Evolution and Therapeutic Choice Seen through a Prism of Circulating Tumor Cell Genomic Instability

Cells, 2021
Circulating tumor cells (CTCs) provide an accessible tool for investigating tumor heterogeneity and cell populations with metastatic potential. Although an in-depth molecular investigation is limited by the extremely low CTC count in circulation ...
Tala Tayoun, Marianne Oulhen, Agathe Aberlenc, Françoise Farace, Patrycja Pawlikowska   +4 more
doaj   +1 more source

RNA-Based CTC Analysis Provides Prognostic Information in Metastatic Breast Cancer

Diagnostics, 2021
In metastatic breast cancer (MBC) the molecular characterization of circulating tumor cells (CTCs) provides a unique tool to understand metastasis-biology and therapy-resistance.
Areti Strati, Michail Nikolaou, Vassilis Georgoulias, Evi S. Lianidou   +3 more
doaj   +1 more source

Comprehensive liquid biopsy analysis as a tool for the early detection of minimal residual disease in breast cancer

Scientific Reports, 2023
Liquid biopsy (LB) provides a unique minimally invasive tool to follow-up cancer patients over time, to detect minimal residual disease (MRD), to study metastasis-biology and mechanisms of therapy-resistance.
Dimitra Stergiopoulou, Athina Markou, Areti Strati, Martha Zavridou, Eleni Tzanikou, Sophia Mastoraki, Galatea Kallergi, Vassilis Georgoulias, Evi Lianidou   +8 more
doaj   +1 more source

The Effect of Genomic DNA Contamination on the Detection of Circulating Long Non-Coding RNAs: The Paradigm of MALAT1

Diagnostics, 2021
The presence of contaminating gDNA in RNA preparations is a frequent cause of false positives in RT-PCR-based analysis. However, in some cases, this cannot be avoided, especially when there are no exons–intron junctions in the lncRNA sequences.
Athina N. Markou, Stavroula Smilkou, Emilia Tsaroucha, Evi Lianidou   +3 more
doaj   +1 more source

KMT2C promoter methylation in plasma‐circulating tumor DNA is a prognostic biomarker in non‐small cell lung cancer

Molecular Oncology, 2021
MLL3 histone methyltransferase, encoded by the KMT2C gene, is a tumor suppressor that has an essential role in cell‐type‐specific gene expression.
Sofia Mastoraki, Ioanna Balgkouranidou, Emily Tsaroucha, Apostolos Klinakis, Vassilis Georgoulias, Evi Lianidou   +5 more
doaj   +1 more source

Gene expression in circulating tumor cells reveals a dynamic role of EMT and PD-L1 during osimertinib treatment in NSCLC patients

Scientific Reports, 2021
Liquid biopsy is a tool to unveil resistance mechanisms in NSCLC. We studied changes in gene expression in CTC-enriched fractions of EGFR-mutant NSCLC patients under osimertinib.
Aliki Ntzifa, Areti Strati, Galatea Kallergi, Athanasios Kotsakis, Vassilis Georgoulias, Evi Lianidou   +5 more
doaj   +1 more source

Detection and relevance of epigenetic markers on ctDNA: recent advances and future outlook

Molecular Oncology, 2021
Liquid biopsy, a minimally invasive approach, is a highly powerful clinical tool for the real‐time follow‐up of cancer and overcomes many limitations of tissue biopsies.
Evi Lianidou
doaj   +1 more source

Evaluation of Monocarboxylate Transporter 4 (MCT4) Expression and Its Prognostic Significance in Circulating Tumor Cells From Patients With Early Stage Non-Small-Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Purpose: Monocarboxylate transporter 4 (MCT4) can influence the amount of lactate in the tumor microenvironment and further control cancer cell proliferation, migration, and angiogenesis.
Athina Markou, E. Tzanikou, G. Kallergi, E. Pantazaka, V. Georgoulias, A. Kotsakis, E. Lianidou   +6 more
doaj   +1 more source

Circulating Cell-Free DNA in Dogs with Mammary Tumors: Short and Long Fragments and Integrity Index [PDF]

, 2017
Circulating cell-free DNA (cfDNA) has been considered an interesting diagnostic/prognostic plasma biomarker in tumor-bearing subjects. In cancer patients, cfDNA can hypothetically derive from tumor necrosis/apoptosis, lysed circulating cells, and some ...
A Asmarinah, A Fawzy, A Jemal, A Matos, Alessandro Sammarco, Andrea Saccani, Antonio Mollo, BG Wang, BT Kurien, C Alix-Panabières, C Qian, CH Lee, Chiara Bedin, Chiara Romualdi, D Bostock, D El-Gayar, D Madhavan, D Merlo, Davide Trez, DMW Schaefer, Donato Nitti, E Coustan-Smith, E Gormally, EM Tan, F Salvianti, FH Igney, GB Gelaleti, Giorgia Beffagna, H Schwarzenbach, H Schwarzenbach, J Beck, J Ferlay, JC Thompson, K Jung, K Pilichou, K Sorenmo, K Sorenmo, Kristy L. Richards, KS Borge, L Ouyang, L Pena, L Pena, Laura Cavicchioli, LE Lowes, M Agostini, M Geng, M Goldschmidt, M Shackleton, M Stroun, M Stroun, Marco Agostini, Marta Mainenti, MB Giacona, Michelangelo Campanella, MV Jain, N Sleeckx, N Umetani, N Umetani, P Anker, P Hofman, P Rivera, R Agassi, R Brodey, R Kumaraguruparan, R Kumaraguruparan, Raffaella De Maria, Re Ellsworth, S Baspinar, S Cargnin, S Iqbal, S Jahr, S Volik, SA Leon, Silvia Ferro, T Hao, T Imamura, T Skvortsova, Valentina Zappulli, W Ayala, W Wang   +79 more
core   +11 more sources