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Self-organizing magnetic beads for biomedical applications [PDF]
Journal of Magnetism and Magnetic Materials 324.6 (2012): 977-982, 2011 In the field of biomedicine magnetic beads are used for drug delivery and to treat hyperthermia. Here we propose to use self-organized bead structures to isolate circulating tumor cells using lab-on-chip technologies. Typically blood flows past microposts functionalized with antibodies for circulating tumor cells.
Akoun +15 more
arxiv +3 more sources
Circulating Tumor Cells for Glioma [PDF]
Frontiers in Oncology, 2021 Liquid biopsy has entered clinical applications for several cancers, including metastatic breast, prostate, and colorectal cancer for CTC enumeration and NSCLC for EGFR mutations in ctDNA, and has improved the individualized treatment of many cancers, but relatively little progress has been made in validating circulating biomarkers for brain ...
Yuan Fan'en +4 more
openaire +5 more sources
The importance of circulating tumor products as „liquid biopsies” in colorectal cancer [PDF]
Journal of Mind and Medical Sciences, 2018 Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA).
Calborean, Veronica +6 more
core +7 more sources
Liquid biopsy in advanced NSCLC: EpCAM+ and EpCAM– circulating tumor cells, tumor derived extracellular vesicles and cell-free circulating tumor DNA. [PDF]
, 2017 S. de Wit et al., Liquid biopsy in advanced NSCLC: EpCAM+ and EpCAM– circulating tumor cells, tumor derived extracellular vesicles and cell-free circulating tumor DNA ...
Mutter-de Wit, Sanne
core +9 more sources
A mathematical model of tumor self-seeding reveals secondary metastatic deposits as drivers of primary tumor growth [PDF]
, 2012 Two models of circulating tumor cell (CTC) dynamics have been proposed to explain the phenomenon of tumor 'self-seeding', whereby CTCs repopulate the primary tumor and accelerate growth: Primary Seeding, where cells from a primary tumor shed into the vasculature and return back to the primary themselves; and Secondary Seeding, where cells from the ...
Anderson, Alexander R. A. +3 more
arxiv +4 more sources
Metastasis and circulating tumor cells [PDF]
EJIFCC, 2012 Cancer is a prominent cause of death worldwide. In most cases, it is not the primary tumor which causes death, but the metastases. Metastatic tumors are spread over the entire human body and are more difficult to remove or treat than the primary tumor ...
Dalum, G. van +2 more
core +4 more sources
Proceedings of the National Academy of Sciences, 2013 A typical cancerous tumor contains millions or even billions of cells harboring genetic mutations driving them to grow, divide, and invade the local tissue in which they’re embedded. However, as the cells proliferate, they don’t all stay in the neighborhood.
Plaks, Vicki +2 more
openaire +6 more sources
Tumor Hypoxia and Circulating Tumor Cells [PDF]
International Journal of Molecular Sciences, 2020 Circulating tumor cells (CTCs) are a rare tumor cell subpopulation induced and selected by the tumor microenvironment’s extreme conditions. Under hypoxia and starvation, these aggressive and invasive cells are able to invade the lymphatic and circulatory systems.
Tinganelli W., Durante M.
openaire +5 more sources
Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models [PDF]
Current Medicinal Chemistry, 2018, 2021 In the present review, we describe three hot topics in cancer research such as circulating tumor cells, exosomes, and 3D environment models. The first section is dedicated to microfluidic platforms for detecting circulating tumor cells, including both affinity based methods that take advantage of antibodies and aptamers, and label free approaches ...
arxiv +1 more source
JAMA Oncology, 2015 Circulating Tumor Cells (CTC) are shed from primary or secondary tumors. Prior studies have demonstrated that enumeration of CTC is a robust independent prognostic factor of progression free and overall survival in patients with early and metastatic breast cancer.
Daniel F. Hayes, Costanza Paoletti
openaire +5 more sources