Results 31 to 40 of about 5,637,645 (256)

Radiomics and circulating tumor cells: personalized care in hepatocellular carcinoma? [PDF]

, 2015
Personalized care in oncology is expected to significantly improve morbidity and mortality, facilitated by our increasing understanding of the molecular mechanisms driving tumors and the ability to target those drivers.
Richard L. Hesketh, Andrew X. Zhu, Rahmi Oklu   +2 more
core   +1 more source

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Peter Fraunberger, Karl Werdan, Werdan, Karl, Walli, Autar K., Autar K. Walli, Dietrich Seidel, Seidel, Dietrich, Steffen Schaefer, Fraunberger, Peter, Schaefer, Steffen   +9 more
core   +1 more source

Liquid Biopsy Analysis as a Tool for TKI-Based Treatment in Non-Small Cell Lung Cancer

Cells, 2022
The treatment of non-small cell lung cancer (NSCLC) has recently evolved with the introduction of targeted therapy based on the use of tyrosine kinase inhibitors (TKIs) in patients with certain gene alterations, including EGFR, ALK, ROS1, BRAF, and MET ...
Karolina Buszka, Aliki Ntzifa, Barbara Owecka, Paula Kamińska, Agata Kolecka-Bednarczyk, Maciej Zabel, Michał Nowicki, Evi Lianidou, Joanna Budna-Tukan   +8 more
doaj   +1 more source

The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target [PDF]

, 2012
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting synovial joints in which the development of autoantibodies represents a failure of normal tolerance mechanisms, suggesting a role for follicular helper T cells (TFH) in the ...
Chakera, Aron, Bowness, Paul, Raashid A. Luqmani, Morteau, O, Luqmani, Raashid, Bennett, S., Richard J. Cornall, Bowness, P., Luqmani, Raashid A, Bennett, Sophia C, Morteau, O., Aron Chakera, Sophia C. Bennett, Paul Bowness, Morteau, Olivier, Cornall, Richard J, Bennett, SC, Olivier Morteau, Cornall, R., Cornall, Richard, Chakera, A, Luqmani, R.   +21 more
core   +1 more source

High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors

Cells, 2020
Circulating tumor cells (CTCs) are cells shed from the primary tumor into the bloodstream. While many studies on solid tumor cells exist, data on CTCs are scarce. The mortality of cancer is mostly associated with metastasis and recent research identified
Daniel J. Smit, Laure Cayrefourcq, Marie-Therese Haider, Nico Hinz, Klaus Pantel, Catherine Alix-Panabières, Manfred Jücker   +6 more
doaj   +1 more source

Significance of Studying Circulating Tumor Cells

, 2016
Circulating Tumor Cells (CTC) are tumor cells released into blood. They are considered the pivotal component of the metastatic cascade and are being extensively studied only in the last decade or so.
Richard J. Cote, Cote, Richard J, Zheng Ao, Datar, Ram H, Ram H. Datar, Ao, Zheng   +5 more
core   +1 more source

EpCAM-Expressing Circulating Tumor Cells in Colorectal Cancer

The International Journal of Biological Markers, 2017
Background Several studies have raised the issue of the inadequacy of CellSearch ® to detect the entire pool of circulating tumor cells (CTCs) from blood of cancer patients, suggesting that cells expressing low levels of epithelial cell adhesion molecule
Chiara Nicolazzo, Cristina Raimondi, Federica Francescangeli, Simona Ceccarelli, Patrizia Trenta, Valentina Magri, Cinzia Marchese, Ann Zeuner, Angela Gradilone, Paola Gazzaniga   +9 more
doaj   +1 more source

Microfilter-Based Capture and Release of Viable Circulating Tumor Cells

, 2017
Microfilters with slot-pore geometry can be used for size-based capture of circulating tumor cells (CTC) from the blood of cancer patients. The slot pore geometry reduces the shear stress that the cells would typically experience during filtration ...
Siddarth Rawal, Zheng Ao, Agarwal, Ashutosh, Datar, Ram H, Ashutosh Agarwal, Ram H. Datar, Rawal, Siddarth, Ao, Zheng   +7 more
core   +1 more source

Multiplex detection of ten ESR1 mutations and AKT1 E17K in breast cancer using digital PCR

The Journal of Liquid Biopsy
Introduction: ESR1 mutations are now established as a key mechanism of resistance to endocrine therapy in estrogen-receptor–positive breast cancer (ER​+ ​breast cancer) and their sensitive and specific detection in plasma-cell free DNA (plasma-cfDNA) is ...
Stavroula Smilkou, Aliki Ntzifa, Dimitra Stergiopoulou, Vasilis Georgoulias, Evi Lianidou   +4 more
doaj   +1 more source

PIK3CA hotspot mutations in circulating tumor cells and paired circulating tumor DNA in breast cancer: a direct comparison study

Molecular Oncology, 2019
Liquid biopsy analysis, mainly based on circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), provides an extremely powerful tool for the molecular profiling of cancer patients in real time.
Eleni Tzanikou, Athina Markou, Eleni Politaki, Anastasios Koutsopoulos, Amanda Psyrri, Dimitris Mavroudis, Vassilis Georgoulias, Evi Lianidou   +7 more
doaj   +1 more source