Results 31 to 40 of about 6,048,216 (301)

SnapShot: Circulating Tumor Cells [PDF]

Cell, 2017
Circulating tumor cells in the blood of patients are both signal flares for the existence of a tumor and harbingers of metastasis. With recent technological developments, these cells can be isolated and analyzed to provide insights into the biology of cancer spread and response to therapy and to offer new avenues for blood biomarker development.
Caroline, Dive, Ged, Brady
openaire   +3 more sources

Clinical Significance of PD-L1 Status in Circulating Tumor Cells for Cancer Management during Immunotherapy

Biomedicines, 2023
The approval of monoclonal antibodies against programmed death-ligand 1 (PD-L1) and programmed cell death protein (PD1) has changed the landscape of cancer treatment. To date, many immune checkpoint inhibitors (ICIs) have been approved by the FDA for the
Areti Strati, Panagiota Economopoulou, Evi Lianidou, Amanda Psyrri   +3 more
doaj   +1 more source

Circulating tumor cell technologies [PDF]

Molecular Oncology, 2016
Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of CTCs lies in the ability to detect and isolate these rare cells using methods amenable to downstream characterization and other applications. In this review, we will
Meghaan M, Ferreira, Vishnu C, Ramani, Stefanie S, Jeffrey   +2 more
openaire   +2 more sources

CTC-Derived Models: A Window into the Seeding Capacity of Circulating Tumor Cells (CTCs)

Cells, 2019
Metastasis is the main cause of cancer-related death owing to the blood-borne dissemination of circulating tumor cells (CTCs) early in the process.
Tala Tayoun, Vincent Faugeroux, Marianne Oulhen, Agathe Aberlenc, Patrycja Pawlikowska, Françoise Farace   +5 more
doaj   +1 more source

Detection of Tumor Cell-Specific mRNA in the Peripheral Blood of Patients with Breast Cancer-Evaluation of Several Markers with Real-Time Reverse Transcription-PCR [PDF]

, 2013
It is widely known that cells from epithelial tumors, e. g., breast cancer, detach from their primary tissue and enter blood circulation. We show that the presence of circulating tumor cells (CTCs) in samples of patients with primary and metastatic ...
Simone Hofmann, Kölbl, Alexandra C., Jeschke, Udo, Klaus Friese, Andergassen, Ulrich, Neugebauer, Julia, Alexandra Kölbl, Udo Jeschke, Matthias Ilmer, Julia Neugebauer, Ilmer, Matthias, Ulrich Andergassen, Engelstädter, Verena, Schindlbeck, Christian, Hofmann, Simone, Hutter, Stefan, Stefan Hutter, Ra C. Kölbl, Friese, Klaus, Verena Engelstädter, Christian Schindlbeck   +20 more
core   +1 more source

PD-L1/pS6 in Circulating Tumor Cells (CTCs) during Osimertinib Treatment in Patients with Non-Small Cell Lung Cancer (NSCLC)

Biomedicines, 2022
The PD-1/PD-L1 axis provides CTCs an escape route from the immune system. Phosphorylation of the ribosomal protein S6 is implicated in the same pathway, following mTOR activation. The aim of the study was to investigate the expression of PD-L1 and pS6 in
Evangelia Pantazaka, Aliki Ntzifa, Argyro Roumeliotou, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Galatea Kallergi   +6 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma. [PDF]

Mol Oncol
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Flach S, Abaci G, Huberty T, Lechner A, Käsmann L, Ricke J, Stöcklein S, Canis M, Baumeister P, Alunni-Fabbroni M.   +9 more
europepmc   +2 more sources

Prognostic Significance of TWIST1, CD24, CD44, and ALDH1 Transcript Quantification in EpCAM-Positive Circulating Tumor Cells from Early Stage Breast Cancer Patients

Cells, 2019
(1) Background: The aim of the study was to evaluate the prognostic significance of EMT-associated (TWIST1) and stem-cell (SC) transcript (CD24, CD44, ALDH1) quantification in EpCAM+ circulating tumor cells (CTCs) of early breast cancer patients.
Areti Strati, Michail Nikolaou, Vassilis Georgoulias, Evi S. Lianidou   +3 more
doaj   +1 more source

In vitro cross-talk between metastasis-competent circulating tumor cells and platelets in colon cancer: a malicious association during the harsh journey in the blood

Frontiers in Cell and Developmental Biology, 2023
Background: Platelets are active players in hemostasis, coagulation and also tumorigenesis. The cross-talk between platelets and circulating tumor cells (CTCs) may have various pro-cancer effects, including promoting tumor growth, epithelial-mesenchymal ...
Zahra Eslami-S, Zahra Eslami-S, Zahra Eslami-S, Luis Enrique Cortés-Hernández, Luis Enrique Cortés-Hernández, Luis Enrique Cortés-Hernández, Ilias Glogovitis, Ilias Glogovitis, Ilias Glogovitis, Mafalda Antunes-Ferreira, Mafalda Antunes-Ferreira, Mafalda Antunes-Ferreira, Silvia D’Ambrosi, Silvia D’Ambrosi, Silvia D’Ambrosi, Keerthi Kurma, Keerthi Kurma, Keerthi Kurma, Françoise Garima, Françoise Garima, Françoise Garima, Laure Cayrefourcq, Laure Cayrefourcq, Laure Cayrefourcq, Myron G. Best, Myron G. Best, Myron G. Best, Danijela Koppers-Lalic, Thomas Wurdinger, Thomas Wurdinger, Thomas Wurdinger, Catherine Alix-Panabières, Catherine Alix-Panabières, Catherine Alix-Panabières   +33 more
doaj   +1 more source

Radiomics and circulating tumor cells: personalized care in hepatocellular carcinoma? [PDF]

, 2015
Personalized care in oncology is expected to significantly improve morbidity and mortality, facilitated by our increasing understanding of the molecular mechanisms driving tumors and the ability to target those drivers.
Richard L. Hesketh, Andrew X. Zhu, Rahmi Oklu   +2 more
core   +1 more source