Peptidylarginine deiminase 4-mediated citrullination in human disease: molecular mechanisms and therapeutic targeting. [PDF]
Front PharmacolZou P, Su XD, Tian W, Xie XY, Yang K.
europepmc +1 more source
Molecular origin, discovery, validation and application of neoantigens. [PDF]
Asian J Pharm SciLyu Q, Hu S.
europepmc +1 more source
Neutrophil extracellular traps in rheumatoid arthritis: pathogenic mechanisms and therapeutic potential. [PDF]
Front ImmunolMao CL +4 more
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Citrullination of Amyloid-β Peptides in Alzheimer’s Disease
ACS Chemical Neuroscience, 2021Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullination has been shown to colocalize with extracellular amyloid plaques in postmortem AD patient brains. Amyloid-β (Aβ) peptides which aggregate and accumulate in the plaques of Alzheimer's disease (AD) have sequential N-terminal ...
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Application of synthetic peptides for detection of anti-citrullinated peptide antibodies
Peptides, 2016Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and represent an important tool for the serological diagnosis of RA. In this study, we describe ACPA reactivity to overlapping citrullinated Epstein-Barr virus nuclear antigen-1 (EBNA-1)-derived peptides and analyze their potential as substrates for ACPA detection
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Biologically Active Citrulline Peptides
Nature, 1962To the best of our knowledge no peptides have so far been synthesized with citrulline as a building component. This alone could be sufficient reason to study citrulline peptides, but our investigations were prompted by other considerations as well.
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Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis [PDF]
Clinical Chemistry and Laboratory Medicine, 2009 The goal of the study was to assess the presence of antibodies to mutated citrullinated vimentin (anti-MCV) and cyclic citrullinated peptides (anti-CCP) in patients with juvenile idiopathic arthritis (JIA) compared with patients with other juvenile onset rheumatic diseases.The study included 56 patients who fulfilled the International League of ...
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Citrullinated Peptides in the Diagnosis of Rheumatoid Arthritis
Current Topics in Medicinal Chemistry, 2013Antibodies directed against citrullinated proteins and peptides (ACPAs) are the most specific serological markers available for diagnosing rheumatoid arthritis (RA). ACPAs may be detected several years before symptoms of RA appear, and their presence at disease onset is a good predictor of the development of erosive joint lesions.
María J, Gómara, Isabel, Haro
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Citrulline and anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis
Future Rheumatology, 2006Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by the destruction of multiple joints along with multiple organ involvement. The etiology of RA is still unknown. Various autoantigens have been proposed as targets of pathogenic T and B cells in RA, although none of their precise mechanisms or significance has been confirmed ...
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Immune tolerance of citrullinated peptides
Nature Reviews RheumatologyRe-establishing tolerance to autoantigens is an important aim for the treatment of rheumatoid arthritis (RA). Immunization of HLA-DR4 transgenic mice with citrullinated self-antigens can induce immune tolerance, which suggests that such antigens could have a therapeutic role in anti-citrullinated peptide antibody-positive RA.
Ranjeny Thomas, William H. Robinson
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