Results 181 to 190 of about 6,340 (217)
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Specific modification of peptide-bound citrulline residues
Analytical Biochemistry, 2006Immune reactions to citrulline-containing proteins appear to be central in the immunopathogenesis of rheumatoid arthritis. Citrulline residues are introduced into proteins by deimination of arginine residues, likely by an enzymatic process. There is a need to characterize which proteins in the inflamed joints of rheumatoid patients contain citrulline ...
Anders, Holm +5 more
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Diagnostic and prognostic usefulness of antibodies to citrullinated peptides
Joint Bone Spine, 2009The diagnosis of rheumatoid arthritis (RA) must be made early, because prompt initiation of treatments tailored to disease activity is crucial to improve structural and functional outcomes. Anti-citrullinated peptide antibodies (ACPAs) are well-established diagnostic markers for RA and should be included in the classification criteria.
Vincent, Goëb +5 more
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Specific biotinylation and sensitive enrichment of citrullinated peptides
Analytical and Bioanalytical Chemistry, 2013Protein citrullination is a posttranslational modification where peptidylarginine is enzymatically deiminated to form peptidylcitrulline. Although the role of protein citrullination in both health and disease is being increasingly recognised, techniques available to identify citrullinated proteins and to map their citrullination site(s) are rare and ...
Astrid E V, Tutturen +2 more
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Antibodies to cyclic citrullinated peptides in psoriatic arthritis.
The Journal of rheumatology, 2005To determine the presence and clinical significance of antibodies to cyclic citrullinated peptides (anti-CCP) in psoriatic arthritis (PsA).We performed a cross-sectional study on 102 outpatients (56 men) with PsA consecutively recruited from a tertiary referral center. Median disease duration was 36 months (interquartile range 21-81). All patients were
Bogliolo, Laura +5 more
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Antibodies to viral citrullinated peptide in rheumatoid arthritis.
The Journal of rheumatology, 2006To analyze the frequency of anti-viral citrullinated peptide (anti-VCP) antibodies in sera from patients with rheumatoid arthritis (RA) by an Epstein-Barr virus (EBV)-derived peptide in which arginine is replaced with citrulline.Anti-VCP antibodies were determined in 627 serum samples, 300 from patients with RA and 327 from controls, including ...
ANZILOTTI C +5 more
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Antibodies to citrullinated peptides and risk of coronary heart disease
Atherosclerosis, 2013Increased cardiovascular risk has been associated with high levels of serum antibodies to citrullinated proteins (ACPA) in patients with rheumatoid arthritis (RA). Citrullination is part of many chronic inflammatory processes and we therefore investigated whether ACPA might be associated with coronary artery disease, in the absence of RA.To maximize ...
Geraldine, Cambridge +4 more
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Anti-cyclic citrullinated peptide antibodies in scleroderma patients
Clinical Rheumatology, 2012Anti-CCP (cyclic citrullinated peptide) is considered the most useful laboratory tool in the diagnosis of rheumatoid arthritis (RA). Some authors have also found this autoantibody in patients with scleroderma (SSc). The study aimed to investigate the prevalence of anti-CCP antibodies in SSc patients from Southern Brazil and their association with ...
M, Polimeni +3 more
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Citrullinated peptide and its relevance to rheumatoid arthritis: an update
International Journal of Rheumatic Diseases, 2010AbstractCitrullinated peptides in autoimmune diseases have been extensively studied in the last two decades. It is suggested that citrullination and the anti‐citrullinated peptide antibodies (ACPA) plays a critical role in initiating inflammatory responses in autoimmune diseases, such as rheumatoid arthritis (RA).
Stanislav, Luban, Zhan-Guo, Li
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The Use of Citrullinated Peptides for the Diagnosis and Prognosis of Rheumatoid Arthritis
Current Topics in Medicinal Chemistry, 2014Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint inflammation and extra-articular manifestations. To prevent progressive and irreversible structural damage, early diagnosis of RA is of paramount importance.
Isabel, Haro, Maria J, Gómara
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Anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis
Modern Rheumatology, 2006Anticyclic citrullinated peptide (anti-CCP) antibodies have been detected in patients with juvenile idiopathic arthritis (JRA), particularly in those with polyarticular JIA. We analyzed the presence of anti-CCP antibodies of the IgG class in sera of patients with defined juvenile idiopathic arthritis (JIA) of various subgroups.
Jürgen K H, Brunner +1 more
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