Results 81 to 90 of about 12,205 (240)

Dendritic cells and the promise of antigen-specific therapy in rheumatoid arthritis [PDF]

, 2013
Rheumatoid arthritis (RA) is a systemic inflammatory disease resulting from an autoimmune response to self-antigens, leading to infl ammation of synovial tissue of joints and subsequent cartilage and bone erosion. Current disease-modifying anti-rheumatic
Thomas, Ranjeny
core   +2 more sources

Citrullinated α-enolase is an effective target for anti-cancer immunity

OncoImmunology, 2018
Targeting post-translationally modified epitopes may provide a new strategy for generating tumor specific immune responses. Citrullination is the post-translational modification of arginine to citrulline catalyzed by peptidylarginine deaminase (PAD ...
Katherine Cook, Ian Daniels, Peter Symonds, Tracy Pitt, Mohamed Gijon, Wei Xue, Rachael Metheringham, Lindy Durrant, Victoria Brentville   +8 more
doaj   +1 more source

Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis [PDF]

, 2017
Objective The pathogenetic mechanisms by which HLA-DRB1 alleles are associated with anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) are incompletely understood. RA high-risk HLA-DRB1 alleles are known to share a common motif,
Anaparti, Vidyanand, Bernstein, Charles N, Bridie Clemens, E, Deutsch, Aaron J, El-Gabalawy, Hani, Ferucci, Elizabeth D, Heemst, Jurgen van, Hitchon, Carol A, Huizinga, Tom, Kedzierska, Katherine, Law, Soi-Cheng, Meng, Xiaobo, Moustakas, Antonis K, Papadopoulos, George K, Raychaudhuri, Soumya, Reid, Hugh H, Robinson, David B, Rossjohn, Jamie, Scally, Stephen W, Smolik, Irene, Sokolove, Jeremy, Thomas, Ranjeny, Ting, Yi Tian, Toes, René E, Woude, Diane van der   +24 more
core   +2 more sources

Assessment of anti-cyclic citrullinated peptide in psoriatic arthritis [PDF]

BMC Research Notes, 2009
Anti-cyclic citrullinated peptides (anti-CCP) are highly specific diagnostic and prognostic markers for rheumatoid arthritis (RA). They have been also found in psoriatic arthritis (PsA), with controversies as regards clinical and radiological associations.
Galal Zenab A, Hassan Hanan E, Abdel Fattah Nermeen SA, El Okda El Sayed E   +3 more
openaire   +3 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

The Infectious Basis of ACPA-Positive Rheumatoid Arthritis

Frontiers in Microbiology, 2017
Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA.
Lazaros I. Sakkas, Dimitrios Daoussis, Stamatis-Nick Liossis, Dimitrios P. Bogdanos   +3 more
doaj   +1 more source

Autoantibodies in inflammatory arthritis [PDF]

, 2016
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterized by extensive synovitis resulting in erosions of articular cartilage and marginal bone with joint destruction.
Chimenti, Ms, Conigliaro, P, Novelli, L, Perricone, C, Perricone, R, Sunzini, F, Triggianese, P   +6 more
core   +1 more source

Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Patients with juvenile idiopathic arthritis (JIA) frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in patients with JIA remains elusive.
Viola Pitkänen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna‐Mari Schroderus, Liisa Kröger, Tuure Kinnunen   +13 more
wiley   +1 more source

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]

, 2017
The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core   +1 more source

Insights of rheumatoid arthritis risk factors and associations

Journal of Translational Autoimmunity, 2019
Rheumatoid arthritis (RA) is a defective post-translational modification of citrullinated peptides which cause synovial inflammation in joints. The present review elaborates the basic mechanisms of RA and the root causes of molecular mechanisms.
Jangampalli Adi Pradeepkiran
doaj   +1 more source