Results 51 to 60 of about 55,171 (227)

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

Clarithromycin-resistant Helicobacter pylori in Recife, Brazil, directly identified from gastric biopsies by polymerase chain reaction

Arquivos de Gastroenterologia, 2010
CONTEXT: Clarithromycin is the most effective drug used in the eradication of infection by Helicobacter pylori. Due to worldwide increase in resistance, pre-treatment susceptibility testing for clarithromycin is recommended.
Ana Kelly Lins, Roberto A Lima, Marcelo Magalhães   +2 more
doaj   +1 more source

Comparative efficacy of azithromycin versus clarithromycin in combination with beta-lactams to treat community-acquired pneumonia in hospitalized patients: a systematic review

Journal of International Medical Research, 2021
Objective The objective was to compare the efficacy of azithromycin and clarithromycin in combination with beta-lactams to treat community-acquired pneumonia among hospitalized adults.
Jumana Al-Salloum, Syed Wasif Gillani, Rana Kamran Mahmood, Shabaz Mohiuddin Gulam   +3 more
doaj   +1 more source

Bismuth-Based Quadruple Therapy versus Metronidazole-Intensified Triple Therapy as a First-Line Treatment for Clarithromycin-Resistant Helicobacter pylori Infection: A Multicenter Randomized Controlled Trial

Gut and Liver, 2022
Background/Aims: Clarithromycin resistance is a main factor for treatment failure in the context of Helicobacter pylori infection. However, the treatment regimen for clarithromycin-resistant H. pylori infection has not yet been determined.
Seung In Seo, Hyun Lim, Chang Seok Bang, Young Joo Yang, Gwang Ho Baik, Sang Pyo Lee, Hyun Joo Jang, Sea Hyub Kae, Jinseob Kim, Hak Yang Kim, Woon Geon Shin   +10 more
doaj   +1 more source

Impact of creatinine clearance on helicobacter pylori eradication rate in patients with peptic ulcer disease [PDF]

, 2015
Introduction. Gastrointestinal complaints are common in patients with kidney failure. The aim of this study was to investigate the effect of creatinine clearance on Helicobacter pylori (HP) eradication rate in patients with peptic ulcer disease ...
Alimadadi, M., Amirkhanlou, S., Hafezi, A.A., Homapour, S., Seyyedmajidi, M., Vafaeimanesh, J., Vakili, M.A.   +6 more
core  

Low Helicobacter pylori eradication rates with 4- and 7-day regimens in an Iranian population [PDF]

Background: In Iran, there is insufficient information on the efficacy of Helicobacter pylori eradication regimens shorter than 10 days. This study aims at assessing the efficacy of 4- and 7-day H. pylori eradication regimens in a high-incidence area of
بابایی, مسعود, درخشان, محمدحسین, دولتشاهی, شهاب, ستوده منش, رسول, ستوده, مسعود, سیاوشی, فریده, عابدی اردکانی, بهنوش, عرشی, شهنام, فره وش, محمد جعفر, مجیدپور, علی, مرآت, شاهین, ملک زاده, رضا, میکاییلی, جواد, ناصری مقدم, سیاوش, پورشمس, اکرم, یزدانبد, عباس   +15 more
core   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte [PDF]

Journal of the Serbian Chemical Society, 2007
The aim of the present study is to present the different reactivity of azithromycin and clarithromycin (pure and commercial) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry under the same experimental conditions.
Avramov-Ivić Milka L., Petrović Slobodan D., Mijin D.Ž.   +2 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Identification of Erythromycin and Clarithromycin Metabolites Formed in Chicken Liver Microsomes Using Liquid Chromatography–High-Resolution Mass Spectrometry

Foods, 2021
Nontargeted analysis can be used for the rapid screening and confirmatory analysis of veterinary drugs and their metabolites, which are important for the comprehensive safety evaluation of animal-derived foods.
Bo Wang, Soyeon Nam, Eunyeong Kim, Hayoung Jeon, Kiho Lee, Kaizhou Xie   +5 more
doaj   +1 more source