Results 21 to 30 of about 114,464,069 (201)
Definition of the attI1 site of class 1 integrons [PDF]
Microbiology, 2000 Integron-encoded integrases recognize two distinct types of recombination site: attI sites, found in integrons, and members of the 59-base element (59-be) family, found in the integron-associated gene cassettes. The class 1 integron integrase, IntI1, catalyses recombination between attI1 and a 59-be, two 59-be, or two attI1 sites, but events involving ...
Sally R, Partridge +5 more
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Dissemination of Class 1, 2, and 3 Integrons Among Multidrug-Resistant Isolates of Pseudomonas aeruginosa. [PDF]
MicrobiologyopenClinical Pseudomonas aeruginosa isolates showed widespread Class 1 and 2 integrons carrying diverse resistance‐associated gene cassettes, including aadB, blaOXA10‐aac(6′)‐II, and aadB‐blaOXA10‐aac(6′)‐Ib, which were strongly associated with antibiotic resistance phenotypes, highlighting the need for enhanced surveillance and targeted infection‐control ...
Hosseini Bafghi M, Baghaie A, Nazari R.
europepmc +2 more sources
Screening Foodstuffs for Class 1 Integrons and Gene Cassettes. [PDF]
J Vis Exp, 2015 Antibiotic resistance is one of the greatest threats to health in the 21st century. Acquisition of resistance genes via lateral gene transfer is a major factor in the spread of diverse resistance mechanisms. Amongst the DNA elements facilitating lateral transfer, the class 1 integrons have largely been responsible for spreading antibiotic resistance ...
Waldron LS, Gillings MR.
europepmc +4 more sources
Class 1 integron in staphylococci [PDF]
Molecular Biology Reports, 2011 As a major concern in public health, methicillin-resistant staphylococci (MRS) still remains one of the most prevalent pathogens that cause nosocomial infections throughout the world and has been recently labeled as a "super bug" in antibiotic resistance.
Zhenbo, Xu +3 more
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Resistance integrons: class 1, 2 and 3 integrons [PDF]
Annals of Clinical Microbiology and Antimicrobials, 2015 As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for the future treatment of such bacterial infection, antimicrobial resistance has been considered to be one of the currently leading concerns in global public health, and ...
Deng, Yang +9 more
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, 2006 OBJECTIVE: Class 1 integrons are DNA structures that recognize and capture mobile gene cassettes. A considerable portion of the genes encoding antibiotic resistance is integrated into these DNA elements.
Kosmidis, C.; id_orcid +7 more
core +8 more sources
The Evolution of Class 1 Integrons and the Rise of Antibiotic Resistance [PDF]
Journal of Bacteriology, 2008 ABSTRACT Class 1 integrons are central players in the worldwide problem of antibiotic resistance, because they can capture and express diverse resistance genes. In addition, they are often embedded in promiscuous plasmids and transposons, facilitating their lateral transfer into a wide range of pathogens ...
Michael, Gillings +6 more
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Costly Class-1 integrons and the domestication of the the functional integrase [PDF]
Mobile Genetic Elements, 2013 Class-1 integrons play an important role in the emergence and spread of antimicrobial resistance determinants. In a recent study we showed that host fitness was dramatically reduced following acquisition of these elements. These fitness costs were due to the presence of an active integrase and we suggested that the mechanistic explanation was due to ...
Harms, Klaus +2 more
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Graph of class 1 integrons detected in pinniped pups.
, 2022 Total number of class 1 integrons detected in faecal and E. coli isolate DNA in pups at each colony where integrons were detected during each breeding season sampled.
Fiona McDougall (5882756) +4 more
core +1 more source
Environmental Isolate of Rahnella aquatilis Harbors Class 1 Integron [PDF]
Current Microbiology, 2015 The paper presents first description of class 1 integron in an environmental strain of Rahnella aquatilis, a rarely isolated Gram-negative bacterium of the family Enterobacteriaceae. The strain was isolated from the Warta river water, Poland. Class 1 integrase gene was detected by a PCR assay.
Koczura, Ryszard +2 more
openaire +2 more sources