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Classical pathway complement activity in schizophrenia
Neuroscience Letters, 2005There is considerable evidence to suggest a role for complement in the pathogenesis of schizophrenia, but the data related to the classical pathway complement activity in patients with schizophrenia are conflicting. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3 ...
Svetlana, Hakobyan +2 more
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Classical pathway complement activation in Kawasaki syndrome
Journal of Allergy and Clinical Immunology, 1994In this study the complement breakdown products C3d, C4d, Bb and membrane attack complex were measured in plasma of patients with Kawasaki syndrome. The results suggested strong activation of the classical activation pathway. However, there was no significant decrease in hemolytic titer or in the concentrations of the intact proteins C3, C4, and B. The
T, Kohsaka +3 more
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Kinetics of the classical complement activation cascade
Journal of Theoretical Biology, 1990Transient-phase and steady-state equations have been derived for the classical complement activation mechanism. From these equations the corresponding ones for the rapid equilibrium conditions have been derived. We propose an experimental design to determine the kinetic parameters.
B H, Havsteen, R, Varón
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Classical pathway complement activity in Familial Mediterranean fever
Clinical Biochemistry, 2006The present study emphasizes the important role of the immune reactions in the pathogenesis of Familial Mediterranean fever. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3, and C4, were determined in the blood serum of 32 patients with FMF and 28 healthy subjects ...
G M, Mkrtchyan +3 more
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Activation of the classical complement pathway by BioRex-70
Immunology Letters, 1987The cation exchange resin BioRex-70 was able to activate the classical complement pathway in human serum at 37 degrees C over the resin concentration range 0-5% (v/v). Using zymosan-treated human serum, it was found that the activation proceeded as far as complement protein C3.
R J, Vandenberg, S B, Easterbrook-Smith
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Classical pathway of complement activation in mammalian kidneys.
Immunology, 1994Two monoclonal antibodies (mAb M4d2 and M4d3) specific for the alpha 2-fragment (C4d), and one antibody (mAb M4c3) specific for the gamma-chain of human complement protein C4, have been tested for cross-reactivity against mammalian complement. These mAb have also been found to react with C4 from guinea-pig (mAb M4d2 and M4c3) as well as from cattle ...
J, Zwirner +5 more
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Curvature-dependent effects of nanotopography on classical immune complement activation
Acta Biomaterialia, 2018The aim of this study was to investigate how the size of nanosized surface features affect classical immune complement activation through adsorption of IgG and the following binding of C1q. By using model surfaces with immobilized SiO2 nanoparticles of different sizes (8, 32 and 68 nm in diameter), three different curvatures with the same chemistry was
Emma, Westas Janco +2 more
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A microplate assay to measure classical and alternative complement activity
Clinical Chemistry and Laboratory Medicine (CCLM), 2017AbstractBackground:We developed and validated a kinetic microplate hemolytic assay (HA) to quantify classical and alternative complement activity in a single dilution of human plasma or serum.Methods:The assay is based on monitoring hemolysis of sensitized sheep (or uncoated rabbit) red blood cells by means of a 96-well microplate reader.
Puissant-Lubrano, Bénédicte +3 more
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