Results 231 to 240 of about 76,398 (257)
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Curcumin Inhibits the Classical and the Alternate Pathways of Complement Activation
Annals of the New York Academy of Sciences, 2005Curcumin (Cur), the golden yellow phenolic compound in turmeric, is well studied for its medicinal properties. In the current investigation, Cur dissolved using sodium hydroxide solution (CurNa) was tested for in vitro complement inhibitory activity and compared with rosmarinic acid (RA) and quercetin (Qur) dissolved using sodium hydroxide (RANa and ...
Amod P, Kulkarni +2 more
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Classical pathway complement activity in Familial Mediterranean fever
Clinical Biochemistry, 2006The present study emphasizes the important role of the immune reactions in the pathogenesis of Familial Mediterranean fever. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3, and C4, were determined in the blood serum of 32 patients with FMF and 28 healthy subjects ...
G M, Mkrtchyan +3 more
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The Classical Complement Pathway: Activation and Regulation of the First Complement Component
1985Publisher Summary This chapter focuses on the activation and regulation of the first complement component. . The chapter outlines the history of the classical pathway of the complement system. Clq and C1 are bound and activated by immune complexes or aggregates containing IgG or IgM but not by those containing IgA, IgD, or IgE . Among IgG subclasses,
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Biochemistry, 2009
The innate immune response to infection or injury involves an antigen-antibody triggered classical pathway (CP) of complement activation, in which soluble and cell surface plasma proteins cooperatively effect elimination of foreign organisms and damaged host cells.
Halili, Maria A. +4 more
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The innate immune response to infection or injury involves an antigen-antibody triggered classical pathway (CP) of complement activation, in which soluble and cell surface plasma proteins cooperatively effect elimination of foreign organisms and damaged host cells.
Halili, Maria A. +4 more
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Classical pathway of complement activation in mammalian kidneys.
Immunology, 1994Two monoclonal antibodies (mAb M4d2 and M4d3) specific for the alpha 2-fragment (C4d), and one antibody (mAb M4c3) specific for the gamma-chain of human complement protein C4, have been tested for cross-reactivity against mammalian complement. These mAb have also been found to react with C4 from guinea-pig (mAb M4d2 and M4c3) as well as from cattle ...
J, Zwirner +5 more
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The Journal of Immunology, 1977
Abstract Bacterial lipopolysaccharides (LPS) have been demonstrated to activate both the classical and the properdin pathways of complement. The lipid A region of the LPS is responsible for classical pathway activation and the polysaccharide region responsible for properdin pathway activation. Classical pathway activation by lipid A does
D C, Morrison, L F, Kline
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Abstract Bacterial lipopolysaccharides (LPS) have been demonstrated to activate both the classical and the properdin pathways of complement. The lipid A region of the LPS is responsible for classical pathway activation and the polysaccharide region responsible for properdin pathway activation. Classical pathway activation by lipid A does
D C, Morrison, L F, Kline
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Molecular Immunology, 1980
Abstract The lectin concanavalin A (Con A) immobilized on Sepharose 4B was found to bind all the components of the guinea pig and human classical complement pathway except C6, C7 and C9. Fluid-phase Con A inhibited the hemolytic activity of guinea pig and human C2, C3, C5 and C8 and human C2 oxidized with iodine (C2 ox ); however, with the exception ...
A P, Gee, M D, Boyle, J J, Langone
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Abstract The lectin concanavalin A (Con A) immobilized on Sepharose 4B was found to bind all the components of the guinea pig and human classical complement pathway except C6, C7 and C9. Fluid-phase Con A inhibited the hemolytic activity of guinea pig and human C2, C3, C5 and C8 and human C2 oxidized with iodine (C2 ox ); however, with the exception ...
A P, Gee, M D, Boyle, J J, Langone
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Immunopharmacology, 1989
Polyanions and polycations inhibit activity of the alternative and classical pathways of complement. We compared polyanions (commercial porcine heparin, chondroitin sulfate A, chondroitin sulfate B (dermatan sulfate), chondroitin sulfate C and heparatin sulfate) with polycations (salmon sperm protamine sulfate, poly-L-lysine, poly-L-arginine, polybrene
J M, Weiler, R J, Linhardt
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Polyanions and polycations inhibit activity of the alternative and classical pathways of complement. We compared polyanions (commercial porcine heparin, chondroitin sulfate A, chondroitin sulfate B (dermatan sulfate), chondroitin sulfate C and heparatin sulfate) with polycations (salmon sperm protamine sulfate, poly-L-lysine, poly-L-arginine, polybrene
J M, Weiler, R J, Linhardt
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Classical pathway complement activation in association with paraproteinaemia.
Immunology, 1978Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four.
P F, Naish, C, Collins, J, Barratt
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