Results 211 to 220 of about 76,398 (257)

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID. [PDF]

Immunology
Keat SBK, Khatri P, Ali YM, Arachchilage CH, Demopulos G, Baillie K, Miners KL, Ladell K, Jones SA, Davies HE, Price DA, Zelek WM, Morgan BP, Schwaeble WJ, Lynch NJ.   +14 more
europepmc   +1 more source

Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD. [PDF]

Eur J Immunol
Tang J, Zgoda N, Clark SJ.
europepmc   +1 more source

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Control of the classical and the MBL pathway of complement activation

Molecular Immunology, 2000
The activation of complement via the mannan-binding lectin (MBL) pathway is initiated by the MBL complex consisting of the carbohydrate binding molecule, MBL, two associated serine proteases, MASP-1 and MASP-2, and a third protein, MAp19. In the present report we used an assay of complement activation specifically reflecting the physiological activity ...
Thomas Vorup-Jensen, Steffen Thiel, Steen Vang Petersen   +2 more
exaly   +5 more sources

Continual Low-Level Activation of the Classical Complement Pathway [PDF]

Journal of Experimental Medicine, 2001
There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation. Analysis of freshly collected mouse and human plasma revealed that spontaneous C3 activation rapidly occurred with ...
Christopher Parish, Matthew Pickering, Marina Botto   +2 more
exaly   +4 more sources

Classical pathway complement activation on human endothelial cells [PDF]

Molecular Immunology, 2007
Endothelial cells regulate vascular integrity and express complement binding proteins including gC1qR/p33 (gC1qR), which recognize C1q, a subunit of the first component of the classical complement pathway. Experiments were performed to investigate classical complement pathway activation on resting endothelial cells and endothelial cells exposed to ...
Ellinor Peerschke, Berhane Ghebrehiwet, Wei Yin   +2 more
exaly   +3 more sources

Kinetics of the classical complement activation cascade

Journal of Theoretical Biology, 1990
Transient-phase and steady-state equations have been derived for the classical complement activation mechanism. From these equations the corresponding ones for the rapid equilibrium conditions have been derived. We propose an experimental design to determine the kinetic parameters.
B H, Havsteen, R, Varón
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Classical pathway complement activity in schizophrenia

Neuroscience Letters, 2005
There is considerable evidence to suggest a role for complement in the pathogenesis of schizophrenia, but the data related to the classical pathway complement activity in patients with schizophrenia are conflicting. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3 ...
Svetlana, Hakobyan, Anna, Boyajyan, Robert B, Sim   +2 more
openaire   +2 more sources

Classical pathway complement activation in Kawasaki syndrome

Journal of Allergy and Clinical Immunology, 1994
In this study the complement breakdown products C3d, C4d, Bb and membrane attack complex were measured in plasma of patients with Kawasaki syndrome. The results suggested strong activation of the classical activation pathway. However, there was no significant decrease in hemolytic titer or in the concentrations of the intact proteins C3, C4, and B. The
T, Kohsaka, J, Abe, T, Asahina, N, Kobayashi   +3 more
openaire   +2 more sources