Results 111 to 120 of about 1,360,367 (244)

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Establishment of THP-1 Monocytes with Compromised Mitochondrial Functions [PDF]

, 2009
The process of inflammation is important for both normal health and in a number of diseases, such as metabolic disorders, autoimmune diseases, and neurodegenerative diseases. Mitochondria are vital for the functioning of all cells. It had been implicated
Chou, Tzu-wen Joy
core  

Age-associated chemokine receptor expression profiles in human peripheral blood monocyte subsets predict cardiovascular disease risk

Frontiers in Immunology
BackgroundAging is a major contributor to chronic inflammation and coronary artery disease (CAD), yet how age influences monocyte chemokine receptor expression in relation to disease severity remains incompletely defined.Methods and resultsWe performed ...
Ravi K. Komaravolu, Nandini Chatterjee, Sunil Kumar, Jessica L. Allen, Christopher Durant, Runpei Wu, Gabriel Valentin-Guillama, Chantel McSkimming, Fabrizio Drago, Angela M. Taylor, Angela M. Taylor, Yury I. Miller, Klaus Ley, Klaus Ley, Coleen A. McNamara, Coleen A. McNamara, Ahmad Alimadadi, Ahmad Alimadadi, Catherine C. Hedrick, Catherine C. Hedrick   +19 more
doaj   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

The Role of Different Monocyte Subsets in Progression of Coronary Atherosclerotic Lesion

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Circulating monocytes are divided into different subpopulations according to the expression of CD14 and CD16. In this study, we investigated the correlation between the severity of coronary artery disease (CAD) and the frequency ...
Hamideh Rahimi, Mohammad Mehdi Peyghambari, Saeid Taghiloo, Hossein Asgarian-Omran, Reza Alizadeh-Navaei, Ali Heydari, Fatemeh Gabeleh, Abolghasem Ajami   +7 more
doaj  

Effect of non-surgical periodontal therapy on CD14 + CD16+ monocyte counts in peripheral blood samples: a clinical interventional study

BMC Oral Health
Monocytes and their macrophage progeny are thought to be involved in tissue and alveolar bone destruction in periodontal disease. It has been documented that the proportion of (CD14 + CD16+) non-classical monocytes in the blood are elevated in chronic ...
Raghunanthan Jagannathan, Thodur Madapusi Balaji, Suresh Ranga Rao, Meshal Saleh Alosaimi, Shankargouda Patil, Yuliia Siurkel, Marco Cicciù, Giuseppe Minervini   +7 more
doaj   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Monocyte subsets in breast cancer patients under treatment with aromatase inhibitor and mucin-1 cancer vaccine

Journal of Translational Medicine
Background Monocytes comprise subsets of classical, intermediate and non-classical monocytes with distinct anti- or pro-tumor effects in breast cancer (BC).
Viktoria Knöbl, Lukas Maier, Stefan Grasl, Carmen Kratzer, Felix Winkler, Vanessa Eder, Hubert Hayden, Maria Amparo Sahagun Cortez, Monika Sachet, Rudolf Oehler, Sophie Frantal, Christian Fesl, Karin Zehetner, Georg Pfeiler, Rupert Bartsch, Florian Fitzal, Christian F. Singer, Martin Filipits, Michael Gnant, Christine Brostjan   +19 more
doaj   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery

Advanced Science, EarlyView.
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie, Jiahe Liu, Xiangyu Zhao, Siying Yang, Han Sun, Bingqian Jia, Xiaohong Ren, Xintao Chen, Lixin Sun, Li Wu, Caifen Wang, Jiwen Zhang   +11 more
wiley   +1 more source