Results 91 to 100 of about 1,881,470 (286)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Non-classical monocytes sense Hypoxia, regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension

Journal of Immunology, 2020
Key Points Ly6Clo nonclassical monocytes infiltrate the pulmonary vasculature and promote PH. Hif1α regulates the maturation of nonclassical monocytes into infiltrating IMØ.
Yen-Rei A. Yu, Yuryi Malakhau, Chengxiu Yu, Stefan J. Phelan, R. I. Cumming, Matthew J Kan, L. Mao, S. Rajagopal, C. A. Piantadosi, Michael D. Gunn   +9 more
semanticscholar   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Expression of DC-SIGN (CD209) on live CD3-19-56-14+16- (classical) monocytes. [PDF]

, 2023
Expression of DC-SIGN (CD209) on live CD3-19-56-14+16- (classical) monocytes.
Adam D. Wegman (11750252), Lauren E. Bahr (16892347), Mitchell J. Waldran (16892344), Joseph Q. Lu (16892350), Kristen E. Baxter (16892353), Adam T. Waickman (7105667), Stephen J. Thomas (7105673)   +6 more
core   +1 more source

Association of intermediate monocytes with dengue severity among the pediatric population of Odisha, India

Scientific Reports
Dengue virus (DENV) infection in children exhibits varied clinical presentations, wherein the role of monocytes is important in the innate immune response. In this study, laboratory-confirmed DENV pediatric patients (n = 120), with DENV-2 infection, were
Manoj Kumar Dash, Sagnika Samal, Shailesh Rout, Rajesh Kumar Bhola, Janeka Gartia, Ishani Saha, Chinmay Kumar Behera, Hamida Hamdi, Mahesh Chandra Sahu, Biswadeep Das   +9 more
doaj   +1 more source

Disappearance of slan-positive non-classical monocytes for diagnosis of chronic myelomonocytic leukemia with an associated inflammatory state

Haematologica, 2020
The diagnosis of chronic myelomonocytic leukemia (CMML) relies on both a persistent peripheral blood monocytosis (monocytes ≥1x10/L) and monocytes accounting for ≥10% of the white blood cell (WBC) differential count.
S. Tarfi, Bouchra Badaoui, N. Freynet, M. Morabito, Jeffie Lafosse, A. Toma, G. Étienne, J. Micol, I. Sloma, P. Fenaux, E. Solary, Dorothée Sélimoglu-Buet, O. Wagner-Ballon   +12 more
semanticscholar   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Monocyte Phenotypes and Physical Activity in Patients with Carotid Atherosclerosis

Antioxidants, 2022
Atherosclerosis is associated with low-grade inflammation involving circulating monocytes. It has been shown that the levels of intermediate pro-inflammatory monocytes are associated with cardiovascular mortality and risk of ischemic stroke.
Mathilde Mura, Michèle Weiss-Gayet, Nellie Della-Schiava, Erica Chirico, Patrick Lermusiaux, Marie Chambion-Diaz, Camille Faes, Anaelle Boreau, Bénédicte Chazaud, Antoine Millon, Vincent Pialoux   +10 more
doaj   +1 more source

β2-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans

Brain, behavior, and immunity, 2018
Acute exercise preferentially mobilizes cytotoxic T-cells, NK-cells and non-classical monocytes to the bloodstream under the influence of hemodynamic forces and/or (β2-adrenergic receptor (β2-AR) signaling.
R. Graff, Hawley E. Kunz, N. Agha, F. Baker, Mitzi Laughlin, A. B. Bigley, M. Markofski, E. Lavoy, Emmanuel Katsanis, R. Bond, C. Bollard, R. Simpson   +11 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source