Results 91 to 100 of about 1,360,367 (244)

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Single-cell transcriptome analysis reveals the dysregulated monocyte state associated with tuberculosis progression

BMC Infectious Diseases
Background In tuberculosis (TB) infection, monocytes play a crucial role in regulating the balance between immune tolerance and immune response through various mechanisms. A deeper understanding of the roles of monocyte subsets in TB immune responses may
Rong Ma, Wanzhong Yang, Wei Guo, Honglai Zhang, Zemin Wang, Zhaohui Ge   +5 more
doaj   +1 more source

Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis

Scientific Reports, 2017
Monocytes/macrophages are critical in systemic and local inflammation in giant cell arteritis (GCA) and possibly in clinically overlapping polymyalgia rheumatica (PMR). Therefore, we aimed to understand the contribution of monocyte subsets and the CX3CR1-
Yannick van Sleen, Qi Wang, Kornelis S. M. van der Geest, Johanna Westra, Wayel H. Abdulahad, Peter Heeringa, Annemieke M. H. Boots, Elisabeth Brouwer   +7 more
doaj   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes

, 2013
Rationale: The leukocyte response in acute inflammation is characterized by an initial recruitment of neutrophils preceding a second wave of monocytes. Neutrophil-derived granule proteins were suggested to hold an important role in this cellular switch ...
Doering, Yvonne, Megens, Remco T. A., Drechsler, Maik, Wang, Ji-Min, Hackeng, Tilman M., Hackeng, Tilman; id_orcid, Pham, Christine T. N., Wang, Ming-Wei, Weber, Christian, Soehnlein, Oliver, van der Does, Anne M., Gallo, Richard L., von Hundelshausen, Philipp, Döring, Yvonne, Söhnlein, Oliver, Alard, Jean-Eric, Wantha, Sarawuth, Lindbom, Lennart, Hackeng, Tilman   +18 more
core   +1 more source

6-Sulfo LacNAc (Slan) as a Marker for Non-classical Monocytes

Frontiers in Immunology, 2019
Monocytes are subdivided into three subsets, which have different phenotypic and functional characteristics and different roles in inflammation and malignancy.
Thomas P. Hofer, Arjan A. van de Loosdrecht, Christiane Stahl-Hennig, Marco A. Cassatella, Loems Ziegler-Heitbrock   +4 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Epigenetics in non-classical monocytes support their pro-inflammatory gene expression.

, 2020
Non-classical human monocytes are characterized by high-level expression of cytokines like TNF, but the mechanisms involved are elusive. We have identified miRNAs and CpG-methylation sites that are unique to non-classical monocytes, defined via CD14 and ...
Hofer, T.P., Ziegler-Heitbrock, L., Heine, G., Zawada, A.M., Devaux, Y., Zhang, L., Krezdorn, N., Nößner, E., Rotter, B.   +8 more
core   +1 more source

Changes in monocyte subsets are associated with an increased risk of AAA and are surrogate markers for AAA morphology in patients with late-stage disease

Frontiers in Immunology
IntroductionMonocytes play a role in the pathology of abdominal aortic aneurysm (AAA) and can display immunophenotypic heterogeneity. Alterations in monocyte subsets are associated with cardiovascular risk, but their profile in AAA is poorly understood ...
Bianca Hamann, Anna Klimova, Marvin Kapalla, David M. Poitz, Albert Busch, Henning Morawietz, Christian Reeps, Anja Hofmann   +7 more
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source