Results 81 to 90 of about 1,881,470 (286)

Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis.

Immunity
Unlike sessile macrophages that occupy specialized tissue niches, non-classical monocytes (NCMs)-circulating phagocytes that patrol and cleanse the luminal surface of the vascular tree-are characterized by constant movement.
Guilhem R Thierry, É. M. Baudon, Mitchell Bijnen, Alicia Bellomo, M. Lagueyrie, I. Mondor, Louise Simonnet, F. Carrette, Romain Fenouil, S. Keshvari, David A. Hume, David Dombrowicz, Marc Bajénoff   +12 more
semanticscholar   +1 more source

Immunopathogenesis of classical swine fever: role of monocytic cells

Immunology, 1999
Virulent classical swine fever (CSF) represents an immunomodulatory viral infection that perturbs immune functions. Circulatory and immunopathological disorders include leukopenia, immunosuppression and haemorrhage. Monocytic cells – targets for CSF virus (CSFV) infection – could play critical roles in the immunopathology, owing to their production of ...
S M, Knoetig, A, Summerfield, M, Spagnuolo-Weaver, K C, McCullough   +3 more
openaire   +3 more sources

Azithromycin distinctively modulates classical activation of human monocytes in vitro [PDF]

British Journal of Pharmacology, 2012
BACKGROUND AND PURPOSE Azithromycin has been reported to modify activation of macrophages towards the M2 phenotype. Here, we have sought to identify the mechanisms underlying this modulatory effect of azithromycin on human monocytes, classically activated in vitro.EXPERIMENTAL APPROACH Human blood monocytes were primed with IFN‐γ for 24 h and activated
Eraković Haber, Vesna, Bosnar, Martina, Belamarić, Daniela, Murati, Teuta, Vrančić, Mila, Munić Kos, Vesna, Nujić, Krunoslav, Banjanac, Mihailo, Stupin Polančec, Darija, Munić, Vesna   +9 more
openaire   +3 more sources

Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis

Scientific Reports, 2021
Spondyloarthritis (SpA) is characterized by chronic inflammation and structural damage involving spine and peripheral joints. Monocytes, as part of innate immune system, following migration into affected tissue, may play a role in the pathogenesis of SpA.
Małgorzata Stec, Michał Seweryn, Mariusz Korkosz, Zofia Guła, Rafał Szatanek, Kazimierz Węglarczyk, Magdalena Rutkowska-Zapała, Marzena Lenart, Marcin Czepiel, Jarosław Czyż, Jarosław Baran, Anna Gruca, Kamila Wojnar-Lasoń, Paweł Wołkow, Maciej Siedlar   +14 more
doaj   +1 more source

Table_1_Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance.xlsx [PDF]

, 2023
IntroductionDespite significant clinical advancement with the use of immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) there are still a major subset of patients that develop adaptive/acquired resistance.
Aparna Padhye (16458960), Joshua K. Ochieng (14947117), Lixia Diao (184400), Xiaohui Yi (1593094), Yanli Li (173888), Don L. Gibbons (9603549), Jing Wang (6206297), B. Leticia Rodriguez (1953484), Laura A. Gibson (16458963), Luisa M. Solis (12259583), Limo Chen (1324584), Jessica M. Konen (14947111), Jared J. Fradette (15104285), Frank R. Rojas Alvarez (16458957), Xiaofei Zhou (490767), David H. Peng (9603534), Shucheng Miao (16458954)   +16 more
core   +1 more source

Subgroups of monocytes predict cardiovascular events in patients with coronary heart disease. The PHAMOS trial (Prospective Halle Monocytes Study)What this paper addsWhat is known about this topic

Hellenic Journal of Cardiology, 2019
Background: Monocytes can be differentiated by the presence of CD14 and CD16 (CD14++CD16-, classical; CD14++CD16+, intermediate and CD14 + CD16++, non-classical monocytes). Recent studies have reported conflicting results regarding an association between
Florian Höpfner, Marrit Jacob, Christof Ulrich, Martin Russ, Andreas Simm, Rolf E. Silber, Matthias Girndt, Michel Noutsias, Karl Werdan, Axel Schlitt   +9 more
doaj   +1 more source

Epigenetic aging of classical monocytes from healthy individuals [PDF]

, 2020
ABSTRACT The impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterations, as well as the corresponding proteomic and metabolomic data for plasma ...
Shchukina, Irina, Bagaitkar, Juhi, Shpynov, Oleg, Loginicheva, Ekaterina, Porter, Sofia, Mogilenko, Denis A., Wolin, Erica, Collins, Patrick, Demidov, German, Artomov, Mykyta, Zaitsev, Konstantin, Sidorov, Sviatoslav, Camell, Christina, Bambouskova, Monika, Arthur, Laura, Swain, Amanda, Panteleeva, Alexandra, Dievskii, Aleksei, Kurbatsky, Evgeny, Tsurinov, Petr, Chernyatchik, Roman, Dixit, Vishwa Deep, Jovanovic, Marko, Stewart, Sheila A., Daly, Mark J., Dmitriev, Sergey, Oltz, Eugene M., Artyomov, Maxim N.   +27 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Classical monocytes from patients with pancreatic ductal adenocarcinoma exhibit a significantly altered transcriptome profile compared with healthy volunteers [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorPancreatic Ductal Adenocarcinoma (PDAC) affects approximately 8000 people every ...
Cook, Jenny Anne
core  

Presentation_1_Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance.pptx [PDF]

, 2023
IntroductionDespite significant clinical advancement with the use of immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) there are still a major subset of patients that develop adaptive/acquired resistance.
Aparna Padhye (16458960), Joshua K. Ochieng (14947117), Lixia Diao (184400), Xiaohui Yi (1593094), Yanli Li (173888), Don L. Gibbons (9603549), Jing Wang (6206297), B. Leticia Rodriguez (1953484), Laura A. Gibson (16458963), Luisa M. Solis (12259583), Limo Chen (1324584), Jessica M. Konen (14947111), Jared J. Fradette (15104285), Frank R. Rojas Alvarez (16458957), Xiaofei Zhou (490767), David H. Peng (9603534), Shucheng Miao (16458954)   +16 more
core   +1 more source