Results 231 to 240 of about 359,057 (288)
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Classical pathway complement activity in schizophrenia
Neuroscience Letters, 2005There is considerable evidence to suggest a role for complement in the pathogenesis of schizophrenia, but the data related to the classical pathway complement activity in patients with schizophrenia are conflicting. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3 ...
Anna Boyajyan, Robert Sim
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Classical pathway deficiencies – A short analytical review [PDF]
Molecular Immunology, 2015 Deficiencies in the classical pathway of complement activation have some common features but show also great differences. Deficiencies of each of the components (C1q, C1s, C1r, C4 and C2) imply increased susceptibility to bacterial infections. They are also associated with increased risk to develop systemic lupus erythematosus where deficiency of C1q ...
Truedsson, Lennart,, Lund University.
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Continual Low-Level Activation of the Classical Complement Pathway [PDF]
Journal of Experimental Medicine, 2001 There is evidence that the classical complement pathway may be activated via a “C1-tickover” mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation.
Christopher Parish +2 more
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Classical Complement Pathway [PDF]
, 2016 The complement system is a fundamental part of the body's innate immunity, providing a fast acting defense mechanism against invading organisms, tissue damage, or molecules identified as being ‘nonself.’ The classical complement cascade is initiated ...
Odette Middleton +2 more
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Classical complement pathway factor alterations in narcolepsy
Acta Neuropsychiatrica, 2022AbstractObjective:Narcolepsy is a chronic sleep disorder long hypothesised to be an autoimmune disease. Complement-mediated immune mechanisms have not been investigated in detail in narcolepsy. Our aim was to establish the significance of classical pathway activation in narcolepsy.Methods:Sera of 42 narcolepsy patients and 26 healthy controls were ...
Hande Yüceer +7 more
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Current Protocols in Immunology, 1994
AbstractThis unit describes several assay methods that can be used to determine the functional status of the classical pathway of complement and to quantitate its component proteins. The classical pathway includes C1qrs, C2, C4, C3, C5, C6, C7, C8, and C9, listed in the order in which they interact.
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AbstractThis unit describes several assay methods that can be used to determine the functional status of the classical pathway of complement and to quantitate its component proteins. The classical pathway includes C1qrs, C2, C4, C3, C5, C6, C7, C8, and C9, listed in the order in which they interact.
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Classical pathways of gene regulation by retinoids
2020Retinoic acid receptors were discovered during early studies of the actions and mechanisms of essential vitamins. Vitamin A is metabolized in the body to retinoic acid (RA) which is a key compound in the control of many developmental processes in chordates.
Ehmke, Pohl, Charles W E, Tomlinson
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Effect of Concanavalin A on the Classical Complement Pathway
The Journal of Immunology, 1977Abstract Lysis of sheep erythrocytes (E) sensitized with anti-Forssman antiserum (EA) is inhibited by the action of concanavalin A (Con A) on whole guinea pig complement (GPC). The degree of inhibition observed for a given quantity of GPC was dependent on the Con A concentration.
J J, Langone, M D, Boyle, T, Borsos
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The classic pathways of thyroid hormone metabolism
Molecular and Cellular Endocrinology, 2017Thyroid hormones (TH) are crucial for growth and development and play an important role in energy homeostasis. Although serum TH levels are relatively constant in the physiological state, TH bioavailability at the tissue and cellular level is dependent on local TH metabolism.
Anne H. van der Spek +2 more
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The non-classical functions of the classical complement pathway recognition subcomponent C1q
Immunology Letters, 2010C1q, the ligand recognition subcomponent of the classical complement pathway has steadily been gaining recognition as a bridge between innate and adaptive immunity. C1q has been shown to be involved in the modulation of various immune cells (such as dendritic cells, platelets, microglia cells and lymphocytes), clearance of apoptotic cells, a range of ...
Annapurna, Nayak +3 more
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