Results 51 to 60 of about 4,411,154 (387)

Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure

open access: yesFrontiers in Immunology, 2018
The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and ...
Berhane Ghebrehiwet   +3 more
doaj   +1 more source

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

open access: yesFrontiers in Immunology, 2018
The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz   +6 more
doaj   +1 more source

Complement-coagulation cross-talk: a potential mediator of the physiological activation of complement by low pH

open access: yesFrontiers in Immunology, 2015
The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy   +2 more
doaj   +1 more source

Nonadiabatic transition paths from quantum jump trajectories [PDF]

open access: yes, 2022
We present a means of studying rare reactive pathways in open quantum systems using Transition Path Theory and ensembles of quantum jump trajectories. This approach allows for elucidation of reactive paths for dissipative, nonadiabatic dynamics when the system is embedded in a Markovian environment.
arxiv   +1 more source

Formation of molecular oxygen in ultracold O + OH reaction [PDF]

open access: yes, 2005
We discuss the formation of molecular oxygen in ultracold collisions between hydroxyl radicals and atomic oxygen. A time-independent quantum formalism based on hyperspherical coordinates is employed for the calculations.
A.A. Razborov   +8 more
core   +3 more sources

Complement activation and protein adsorption by carbon nanotubes [PDF]

open access: yes, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel   +5 more
core   +2 more sources

Pathways connecting two opposed bilayers with a fusion pore: A molecularly-informed phase field approach [PDF]

open access: yesSoft Matter, 2020, 16, 366, 2019
A phase field model with two phase fields, representing the concentration and the head-tail separation of amphiphilic molecules, respectively, has been constructed using an extension of the Ohta-Kawasaki model (Macromolecules 19, 2621-2632 (1986)).
arxiv   +1 more source

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

open access: yes, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Barna, Gabor   +6 more
core   +3 more sources

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway [PDF]

open access: yesEuropean Journal of Immunology, 2014
Post‐translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory conditions through myeloperoxidase‐dependent cyanate (CNO−) formation.
Anders Dahl-Knudsen   +13 more
openaire   +8 more sources

Structural Basis of Fosmidomycin Action Revealed by the Complex with 2-C-Methyl-D-erythritol 4-phosphate Synthase (IspC): implications for the catalytic mechanism and anti-malaria drug development [PDF]

open access: yes, 2003
2-C-Methyl-D-erythritol 4-phosphate synthase (IspC) is the first enzyme committed to isoprenoid biosynthesis in the methylerythritol phosphate pathway, which represents an alternative route to the classical mevalonate pathway.
Bacher, Adelbert   +5 more
core   +1 more source

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