Results 31 to 40 of about 359,057 (288)

The Role of Alpha 2 Macroglobulin in IgG-Aggregation and Chronic Activation of the Complement System in Patients With Chronic Lymphocytic Leukemia

Frontiers in Immunology, 2021
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the western world. One of the treatments offered for CLL is immunotherapy.
Naseba Naseraldeen, Naseba Naseraldeen, Regina Michelis, Masad Barhoum, Masad Barhoum, Judith Chezar, Tamar Tadmor, Tamar Tadmor, Ariel Aviv, Lev Shvidel, Lev Shvidel, Adi Litmanovich, Mona Shehadeh, Galia Stemer, Ety Shaoul, Andrei Braester, Andrei Braester   +16 more
doaj   +1 more source

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
core   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
core   +1 more source

Immunoglobulin M-enriched intravenous immunoglobulin inhibits classical pathway complement activation, but not bactericidal activity of human serum [PDF]

, 2004
Acute or even hyperacute humoral graft rejection, mediated by classical pathway complement activation, occurs in allo- and xenotransplantation due to preformed anti-graft antibodies.
Aebi, Christoph, Mohacsi, Paul J, Thomas Laumonier, Christoph Aebi, Walpen, Alexander J, Robert Rieben, Alexander J. Walpen, Paul J. Mohacsi, Laumonier, Thomas, Rieben, Robert   +9 more
core   +1 more source

Surface stabilization determines a classical versus non-classical nucleation pathway during particle formation [PDF]

, 2016
Dreyer A, Eckstädt K, Koop T, Jutzi P, Hütten A. Surface stabilization determines a classical versus non-classical nucleation pathway during particle formation. RSC ADVANCES.
Jutzi, Peter, Hütten, Andreas, Dreyer, A., Koop, Thomas ; https://orcid.org/, Eckstädt, Katrin   +4 more
core   +1 more source

Biochemical and functional studies of a novel complement inhibitor, CRIT, with its interaction partners [PDF]

, 2005
Complement C2 receptor trispanning (CRIT), a three transmembrane receptor, was first discovered on the surface of the parasite Schistosoma haematobium and formerly termed Schistosoma trispanning orphan receptor (Sh-TOR). This receptor acts as decoy C2-
Hui, Kwok-Min
core   +1 more source

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

Frontiers in Immunology, 2018
The complement system is a tightly regulated network of proteins involved in defense against pathogens, inflammatory processes, and coordination of the innate and adaptive immune responses.
Cecilie E. Hertz, Rafael Bayarri-Olmos, Nikolaj Kirketerp-Møller, Sander van Putten, Katrine Pilely, Mikkel-Ole Skjoedt, Peter Garred   +6 more
doaj   +1 more source

Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure

Frontiers in Immunology, 2018
The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and ...
Berhane Ghebrehiwet, Evelyn Kandov, Uday Kishore, Ellinor I. B. Peerschke   +3 more
doaj   +1 more source

Evaluation of the classical complement pathway activation or inhibition. [PDF]

, 2014
Evaluation of the classical complement pathway activation or inhibition.
Jean Guézennec (552126), Anne Bordron (552128), Anthony Courtois (552125), Claire Boisset (552127), Christian Berthou (84446)   +4 more
core   +1 more source

cGAS/STING: novel perspectives of the classic pathway [PDF]

Molecular Biomedicine, 2020
AbstractCyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS activates its downstream adaptor, stimulator of interferon genes (STING). STING then triggers protective immune to enable the elimination of the pathogens and the clearance of cancerous ...
Menghui Gao, Yuchen He, Haosheng Tang, Xiangyu Chen, Shuang Liu, Yongguang Tao   +5 more
openaire   +3 more sources