Results 31 to 40 of about 686,133 (287)

Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure

open access: yesFrontiers in Immunology, 2018
The immunopathological functions associated with human C1q are still growing in terms of novelty, diversity, and pathologic relevance. It is, therefore, not surprising that C1q is being recognized as an important molecular bridge between innate and ...
Berhane Ghebrehiwet   +3 more
doaj   +1 more source

Complement-coagulation cross-talk: a potential mediator of the physiological activation of complement by low pH

open access: yesFrontiers in Immunology, 2015
The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy   +2 more
doaj   +1 more source

Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]

open access: yes, 2011
Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Cross, R. A.   +2 more
core   +2 more sources

Role of mitochondria in Parkinson disease [PDF]

open access: yes, 1999
The cause of the selective degeneration of nigrostriatal neurons in Parkinson disease (PD) has remained largely unknown. Exceptions include rare missense mutations in the alpha-synuclein gene on chromosome 4, a potentially pathogenic mutation affecting ...
Graeber, M. B.   +4 more
core   +1 more source

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

open access: yesFrontiers in Immunology, 2019
Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown.
László József Barkai   +6 more
doaj   +1 more source

Classical analysis of correlated multiple ionization in strong fields

open access: yes, 2000
We discuss the final stages of the simultaneous ionization of two or more electrons due to a strong laser pulse. An analysis of the classical dynamics suggests that the dominant pathway for non-sequential escape has the electrons escaping in a symmetric ...
Bruno Eckhardt   +2 more
core   +1 more source

Is there a classical nonsense-mediated decay pathway in trypanosomes? [PDF]

open access: yesPLoS ONE, 2011
In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2.
Praveen Delhi   +4 more
doaj   +1 more source

Targeting the non-classical estrogen pathway in neurodegenerative diseases and brain injury disorders

open access: yesFrontiers in Endocrinology, 2022
Estrogens can alter the biology of various tissues and organs, including the brain, and thus play an essential role in modulating homeostasis. Despite its traditional role in reproduction, it is now accepted that estrogen and its analogues can exert ...
Zsombor Koszegi, Rachel Y. Cheong
doaj   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

open access: yes, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M   +5 more
core   +1 more source

Inflammasomes and Fibrosis

open access: yesFrontiers in Immunology, 2021
Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors.
Wen-Juan Zhang   +5 more
doaj   +1 more source

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