Peptide inhibitor of complement C1 (PIC1), a novel suppressor of classical pathway activation: mechanistic studies and clinical potential [PDF]
Frontiers in Immunology, 2014 The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses as well as an essential homeostatic role in the clearance of damaged self-antigens.
Julia A Sharp +5 more
doaj +2 more sources
Targeting the non-classical estrogen pathway in neurodegenerative diseases and brain injury disorders [PDF]
Frontiers in Endocrinology, 2022 Estrogens can alter the biology of various tissues and organs, including the brain, and thus play an essential role in modulating homeostasis. Despite its traditional role in reproduction, it is now accepted that estrogen and its analogues can exert ...
Zsombor Koszegi, Rachel Y. Cheong
doaj +3 more sources
The phylogeny of the complement system and the origins of the classical pathway
Immunobiology, 2007 The origins of the complement system have now been traced to near to the beginnings of multi-cellular animal life. Most of the evidence points to the earliest activation mechanism having been more similar to the lectin pathway than to the alternative pathway.
Misao Matsushita, Alister W Dodds
exaly +3 more sources
Characteristics of androgen metabolic pathways in patients with 21-hydroxylase deficiency and their association with disease control status [PDF]
Frontiers in EndocrinologyObjectiveTo investigate the activity characteristics of distinct androgen metabolic pathways in patients with 21-hydroxylase deficiency (21OHD) and their correlation with disease control status, and to elucidate the metabolic pathway features and ...
Hemeng Chong +5 more
doaj +2 more sources
The classical pathway triggers pathogenic complement activation in membranous nephropathy. [PDF]
Nat Commun, 2023 Membranous nephropathy (MN) is an antibody-mediated autoimmune disease characterized by glomerular immune complexes containing complement components. However, both the initiation pathways and the pathogenic significance of complement activation in MN are
Seifert L +23 more
europepmc +3 more sources
The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection [PDF]
Frontiers in Immunology, 2018 Activation of the classical complement pathway occurs to varying degrees within strains of the Borrelia burgdorferi sensu lato complex, which contain a group of pathogenic spirochetes that cause tick-borne Lyme borreliosis, including the agent of Lyme ...
Hui Zhi, Jialei Xie, Jon T. Skare
doaj +2 more sources
Discovery of a metabolic alternative to the classical mevalonate pathway
eLife, 2013 Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes.
Nikki Dellas +3 more
doaj +3 more sources
Proprotein Convertases and the Complement System
Frontiers in Immunology, 2022 Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó +3 more
doaj +1 more source
Journal of Marine Science and Engineering, 2023 In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah +4 more
doaj +1 more source
Frontiers in Immunology, 2021 The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu +7 more
doaj +1 more source