Results 11 to 20 of about 2,657,497 (287)
Is there a classical nonsense-mediated decay pathway in trypanosomes? [PDF]
PLoS ONE, 2011 In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2.
Praveen Delhi +4 more
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Frontiers in Immunology, 2021 The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu +7 more
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Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein
Viruses, 2023 The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection.
Nazar Beirag +9 more
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Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model
Frontiers in Cellular Neuroscience, 2021 Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell loss in this disease.
Sabrina Reinehr +6 more
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Platelets, 2023 Increased platelet destruction is central in the pathogenesis of immune thrombocytopenia. However, impaired platelet production is also relevant and its significance underlies the rationale for treatment with thrombopoietin receptor agonists (TPO-RAs ...
Alexander Åkesson +7 more
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Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients
Biomedicines, 2021 Increased levels of circulating complement activation products have been reported in COVID-19 patients, but only limited information is available on complement involvement at the tissue level.
Paolo Macor +9 more
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Frontiers in Immunology, 2019 C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent
Alessandro Mangogna +11 more
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Role of complement activation in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
Frontiers in Medicine, 2022 Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease characterized by necrotizing inflammation of small or medium vessels, causing ANCA associated glomerulonephritis (AAGN).
Tadasu Kojima, Takashi Oda
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Complement in the Initiation and Evolution of Rheumatoid Arthritis
Frontiers in Immunology, 2018 The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and ...
V. Michael Holers, Nirmal K. Banda
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Frontiers in Immunology, 2021 Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the western world. One of the treatments offered for CLL is immunotherapy.
Naseba Naseraldeen +16 more
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