Results 41 to 50 of about 359,057 (288)

The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice [PDF]

, 2002
The complement system is an important component of the innate immune response to bacterial pathogens, including Streptococcus pneumoniae. The classical complement pathway is activated by antibody–antigen complexes on the bacterial surface and has been ...
James C. Paton, Gilliland, S., Jeremy S. Brown, Walport, Mark J., Sarah M. Gilliland, David W. Holden, Hussell, T., Tracy Hussell, Botto, M., Marina Botto, Paton, J., Holden, David W., Michael R. Ehrenstein, Mark J. Walport, Ehrenstein, Michael R., Hussell, Tracy; id_orcid, Ehrenstein, M., Paton, James C., Holden, D., Gilliland, Sarah M., Walport, M., Botto, Marina, Brown, Jeremy S., Brown, J.   +23 more
core   +1 more source

Lectin domain of aggrecan G3 module activates the classical pathway. [PDF]

, 2013
Aggregated IgG (positive control for classical pathway), LCt, Lt, Ct and BSA (negative control) were coated onto microtiter plates and increasing concentrations of normal human serum (NHS) were added.
Matthias Mörgelin (109607), Anders Aspberg (402464), Camilla Melin Fürst (402462), Kasper Vadstrup (402463), Dick Heinegård (55330), Anna M. Blom (53233)   +5 more
core   +1 more source

Complement-coagulation cross-talk: a potential mediator of the physiological activation of complement by low pH

Frontiers in Immunology, 2015
The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy, Ismet eBoral, Alan eBevington   +2 more
doaj   +1 more source

Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells. [PDF]

, 2009
Summary Inherited deficiencies in components of the classical complement pathway are strong disease susceptibility factors for the development of systemic lupus erythematosus (SLE) and there is a hierarchy among deficiency states, the strongest ...
G Sturfelt, A A Bengtsson, L Truedsson, Gullstrand, Birgitta, U Mårtensson, Mårtensson, Ulla, Sturfelt, Gunnar, Bengtsson, A A, Truedsson, Lennart, B Gullstrand   +9 more
core   +1 more source

A New Tool for Complement Research: In vitro Reconstituted Human Classical Complement Pathway

Frontiers in Immunology, 2018
The complement, as part of the innate immune system, represents the first line of defense against Gram-negative bacteria invading the bloodstream. The complement system is a zymogen cascade that ultimately assemble into the so-called membrane attack ...
Michele Mutti, Katharina Ramoni, Gábor Nagy, Eszter Nagy, Valéria Szijártó   +4 more
doaj   +1 more source

Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency [PDF]

, 2004
Deficiency of mannose-binding lectin (MBL), a recognition molecule of the lectin pathway of complement, is associated with increased susceptibility to infections.
Roos, Anja, Daha, Mohamed R., Matsushita, Misao, Lynch, Nicholas J., Bouwman, Lee H., Faber-Krol, Maria C., Schwaeble, Wilhelm J., Garred, Peter, Wildenberg, Manon E., Schlagwein, Nicole, Munoz, Jeric R., Zuiverloon, Tahlita C. M., Fallaux van den Houten, Francien C., Fujita, Teizo, Madsen, Hans O.   +14 more
core   +1 more source

Role of the Classical Pathway of Complement Activation in Experimentally Induced Polymicrobial Peritonitis [PDF]

, 2001
The complement system and the natural antibody repertoire provide a critical first-line defense against infection. The binding of natural antibodies to microbial surfaces opsonizes invading microorganisms and activates complement via the classical ...
Steffen Thiel (12664), Steffen Thiel, Ilhan Celik, Mark Walport, Cordula Stover, Wilhelm J. Schwaeble (7418447), Marina Botto (4428), Marina Botto, Wilfried Lorenz, Wilfried Lorenz (70498), Dieter Künkel (7580921), Ilhan Celik (7580915), Sotiria Tzima (7580918), Sotiria Tzima, Cordula M. Stover (7117046), Mark Walport (372144), Wilhelm Schwaeble, Dieter Künkel   +17 more
core   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

The classical complement pathway plays a critical role in the opsonisation of uropathogenic Escherichia coli [PDF]

, 2008
Urinary tract infection due to uropathogenic Escherichia coli is a common clinical problem. The innate immune system and the uroepithelium are critical in defence against infection.
Steven H. Sacks, Sheerin, N S, Li, K, Sheerin NS, Sacks, S H; id_orcid, Ke Li, Li K, Neil S. Sheerin, Sacks SH   +8 more
core   +1 more source

An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase [PDF]

, 2020
The classical and lectin pathways of the complement system are important for the elimination of pathogens and apoptotic cells and stimulation of the adaptive immune system.
Zarantonello, Alessandra, Andersen, Gregers R., Yalcin, Esra, Thiel, Steffen, Presumey, Jessy, Carroll, Michael C., Olesen, Heidi Gytz, Johnson, Matthew B., Hansen, Annette, Stevens, Beth, Simoni, Léa, Fox, Rachel, Laursen, Nick Stub   +12 more
core   +1 more source