Results 1 to 10 of about 63,492 (119)

Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks [PDF]

Nature Communications
Clathrin-mediated endocytosis is essential for membrane traffic, impacting a diverse range of cellular processes including cell signaling homeostasis, cell adhesion, and receptor recycling.
Brandon T. Malady, Andromachi Papagiannoula, Advika Kamatar, Susovan Sarkar, Gavin T. Lebrun, Liping Wang, Carl C. Hayden, Eileen M. Lafer, David J. Owen, Sigrid Milles, Jeanne C. Stachowiak   +10 more
doaj   +2 more sources

A CIE change in our understanding of endocytic mechanisms

Frontiers in Cell and Developmental Biology, 2023
The past six decades have seen major advances in our understanding of endocytosis, ranging from descriptive studies based on electron microscopy to biochemical and genetic characterization of factors required for vesicle formation.
Daniel J. Rioux, Daniel J. Rioux, Derek C. Prosser   +2 more
doaj   +1 more source

Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses

eLife, 2022
At postsynaptic sites of neurons, a prominent clathrin-coated structure, the endocytic zone (EZ), controls the trafficking of glutamate receptors and is essential for synaptic plasticity.
Lisa AE Catsburg, Manon Westra, Annemarie ML van Schaik, Harold D MacGillavry   +3 more
doaj   +1 more source

A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly. [PDF]

PLoS ONE, 2016
The clathrin heavy chain N-terminal domain interacts with endocytic adapter proteins via clathrin binding motifs to assemble clathrin triskelia into cages. However, the precise mechanism of clathrin assembly is not yet known.
Lia Moshkanbaryans, Jing Xue, Jesse Ray Wark, Phillip James Robinson, Mark Evan Graham   +4 more
doaj   +1 more source

Effects of the clathrin inhibitor Pitstop-2 on synaptic vesicle recycling at a central synapse in vivo

Frontiers in Synaptic Neuroscience, 2022
Four modes of endocytosis and subsequent synaptic vesicle (SV) recycling have been described at the presynapse to ensure the availability of SVs for synaptic release.
Alp Paksoy, Simone Hoppe, Yvette Dörflinger, Heinz Horstmann, Kurt Sätzler, Christoph Körber   +5 more
doaj   +1 more source

Host Factors Genes BcCLC1 and BcCLC2 Confer Turnip Mosaic Virus Resistance in Non-Heading Chinese Cabbage (Brassica campestris ssp. chinensis)

Plants, 2023
Clathrin is an evolutionarily highly conserved evolutionary protein consisting of clathrin light chains (CLC) and clathrin heavy chains (CHC), and these form its basic structure. Clathrin is an important host factor in the process of viral infection.
Mengguo Yuan, Shanwu Lyu, Yaolong Wang, Liu E, Tongkun Liu, Xilin Hou, Ying Li, Changwei Zhang   +7 more
doaj   +1 more source

Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases

Bioengineering & Translational Medicine, 2023
Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a potent CME inhibitor, we and others have reported on substantial clathrin‐independent inhibitory
Ivan Liashkovich, Sílvio Terra Stefanello, Reshma Vidyadharan, Günter Haufe, Alexander Erofeev, Peter V. Gorelkin, Vasilii Kolmogorov, Caren Rigon Mizdal, Alexander Dulebo, Etmar Bulk, Ian U. Kouzel, Victor Shahin   +11 more
doaj   +1 more source

Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies

Journal of Extracellular Vesicles, 2020
Pregnancy is a unique situation, in which placenta-derived small extracellular vesicles (sEVs) may communicate with maternal and foetal tissues. While relevant to homoeostatic and pathological functions, the mechanisms underlying sEV entry and cargo ...
Hui Li, Itziar Pinilla-Macua, Yingshi Ouyang, Elena Sadovsky, Kazuhiro Kajiwara, Alexander Sorkin, Yoel Sadovsky   +6 more
doaj   +1 more source

Membrane Heterogeneity Controls Cellular Endocytic Trafficking

Frontiers in Cell and Developmental Biology, 2020
Endocytic trafficking relies on highly localized events in cell membranes. Endocytosis involves the gathering of protein (cargo/receptor) at distinct plasma membrane locations defined by specific lipid and protein compositions.
Gregory M. I. Redpath, Gregory M. I. Redpath, Verena M. Betzler, Verena M. Betzler, Pascal Rossatti, Pascal Rossatti, Jérémie Rossy, Jérémie Rossy   +7 more
doaj   +1 more source

Clathrin-independent pathways do not contribute significantly to endocytic flux

eLife, 2014
Several different endocytic pathways have been proposed to function in mammalian cells. Clathrin-coated pits are well defined, but the identity, mechanism and function of alternative pathways have been controversial.
Vassilis Bitsikas, Ivan R Corrêa Jr, Benjamin J Nichols   +2 more
doaj   +1 more source