Claudin-1 and Claudin-3 as Molecular Regulators of Myelination in Leukoaraiosis Patients [PDF]
Clinics, 2021 OBJECTIVES: Leukoaraiosis is described as white matter lesions that are associated with cognitive dysfunction, neurodegenerative disorders, etc. Myelin depletion is a salient pathological feature of, and the loss of oligodendrocytes is one of the most ...
Yan Chen +4 more
doaj +5 more sources
Tight Junctions and Cancer: Targeting Claudin-1 and Claudin-4 in Thyroid Pathologies [PDF]
PharmaceuticalsPurpose: Claudins are tight junction proteins partaking in epithelial-mesenchymal transition and cancer progression. In this study, we investigated the expression patterns of claudin-1 and claudin-4 in thyroid pathologies, discussed their links with the ...
Jędrzej Borowczak +11 more
doaj +4 more sources
Differential Expression of Claudin-3 and Claudin-1 in Mycosis Fungoides: Implications for Disease Monitoring [PDF]
Dermatology Practical & ConceptualIntroduction: Claudins are integral transmembrane proteins that play a pivotal role in regulating tight junctions within epithelial and endothelial cells.
Akın Aktaş +4 more
doaj +5 more sources
Claudin-1, A Double-Edged Sword in Cancer [PDF]
International Journal of Molecular Sciences, 2020 Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated and studied in a multitude of diseases. Claudins not only regulate paracellular transepithelial/transendothelial transport but are
Ajaz A. Bhat +17 more
openaire +6 more sources
Claudin-1 as a promoter of EMT in hepatocellular carcinoma [PDF]
Oncogene, 2013 Claudins are integral structural and functional components of apical cell adhesions (tight junctions). Loss of such adhesions has been associated with malignant transformation, a process most often accompanied by a concomitant loss of claudin expression.
J, Stebbing, A, Filipović, G, Giamas
openaire +4 more sources
Differential Expression of Claudin 1 and 4 in Basal Cell Carcinoma of the Skin [PDF]
Dermatology Research and Practice, 2023 Basal cell carcinoma (BCC) is the most common human malignancy. The biological behavior of this entity is remarkably indolent. Claudin plays an important role in tight junctions, regulating paracellular passage of variable substance including growth ...
T. Nakazawa +7 more
doaj +2 more sources
Claudin 1 in Breast Cancer: New Insights [PDF]
Journal of Clinical Medicine, 2015 Claudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells. A tight junction protein that regulates the paracellular transport of small ions across adjacent cells, claudin 1 maintains cellular polarity and plays a major role in cell-cell communication and epithelial cell homeostasis.
Zhou, Bowen +4 more
openaire +4 more sources
Expression and clinical significance of Claudin-1 and Claudin-3 in the serum of patients with psoriasis vulgaris [PDF]
Pifu-xingbing zhenliaoxue zazhi, 2023 Objective To investigate the expression and clinical significance of serum Claudin-1 and Claudin-3 levels in patients with psoriasis vulgaris (PV). Methods A total of 122 patients with PV were enrolled as the PV group (including 36 cases in the mild ...
Jinzhao MA +4 more
doaj +2 more sources
The activation of adenosine monophosphate–activated protein kinase inhibits the migration of tongue squamous cell carcinoma cells by targeting Claudin‐1 via epithelial–mesenchymal transition [PDF]
Animal Models and Experimental MedicineBackground The role of Claudin‐1 in tongue squamous cell carcinoma (TSCC) metastasis needs further clarification, particularly its impact on cell migration.
Xin‐Yue Zhou +9 more
doaj +2 more sources
Claudin-1 Mediated Tight Junction Dysfunction as a Contributor to Atopic March [PDF]
Frontiers in Immunology, 2022 Atopic march refers to the phenomenon wherein the occurrence of asthma and food allergy tends to increase after atopic dermatitis. The mechanism underlying the progression of allergic inflammation from the skin to gastrointestinal (GI) tract and airways ...
Yuhan Xia +3 more
doaj +2 more sources