Asiatic Acid Inhibits Nasopharyngeal Carcinoma Cell Viability and Migration via Suppressing STAT3 and Claudin-1 [PDF]
Pharmaceuticals, 2023 Nasopharyngeal carcinoma (NPC) is a prevalent cancer in Southeast Asia, but effective treatment options remain limited, and chemotherapy has a high resistance rate.
Supitchaya Pantia +3 more
doaj +2 more sources
Tight junction protein claudin-1 is a novel internalization factor for swine enteric coronaviruses infection [PDF]
mBioSwine enteric coronaviruses (SeCoVs), including transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine deltacoronavirus (PDCoV), have been reported to use aminopeptidase N (APN) as a cellular receptor.
Zhongyuan Li +7 more
doaj +2 more sources
Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-1 [PDF]
Frontiers in Microbiology, 2023 BackgroundTight junctions act as a barrier that prevents invasion of pathogens through epithelial cells. This study aims to elucidate the correlation between tight junctions and nairoviruses using Hazara orthonairovirus (HAZV) as a surrogate model for ...
Keisuke Ohta +3 more
doaj +2 more sources
Expression of claudin 1, claudin 4, and claudin 7 in colorectal cancer and its relation with CLDN DNA methylation patterns [PDF]
Tumor Biology, 2017 Altered claudin expression has been described in colon, prostatic, ovarian, and breast carcinoma. However, the role of epigenetic modifications in these genes and their role in colorectal cancer is unknown.
Victoria Hahn-Strömberg +4 more
doaj +2 more sources
Claudin-1 contributes to the epithelial barrier function in MDCK cells
European Journal of Cell Biology, 1999 Tight junctions (TJs) create a paracellular permeability barrier and also act as a fence preventing intermixing of proteins and lipids between the apical and basolateral plasma membranes. Recently, claudin-1 has been identified as an integral membrane protein localizing at TJs, and introduced claudin-1 can form TJ-like networks in fibroblasts.
Tetsuichiro Inai +2 more
exaly +3 more sources
Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1. [PDF]
Bioorg Med Chem, 2023 Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, despite advancements in diagnosis. The main reason for this is that many newly diagnosed CRC patients will suffer from metastasis to other organs.
Mashinson V +7 more
europepmc +2 more sources
Non-tight junction-related function of claudin-7 in interacting with integrinβ1 to suppress colorectal cancer cell proliferation and migration [PDF]
Cancer Management and Research, 2019 Wenjing Li,1,2 Chang Xu,1 Kun Wang,1 Yuhan Ding,1 Lei Ding1 1Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Binzhou Medical University Hospital, Binzhou, People’s Republic ...
Li W, Xu C, Wang K, Ding Y, Ding L
doaj +1 more source
Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood-Brain Barrier. [PDF]
ACS Nano, 2021 Aging-induced alterations to the blood–brain barrier (BBB) are increasingly being seen as a primary event in chronic progressive neurological disorders that lead to cognitive decline.
Bony BA +9 more
europepmc +2 more sources
Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer. [PDF]
PLoS ONE, 2013 Downregulation of the tight junction protein claudin 1 is a frequent event in breast cancer and is associated with recurrence, metastasis, and reduced survival, suggesting a tumor suppressor role for this protein.
Francescopaolo Di Cello +6 more
doaj +1 more source
Cells, 2021 Tight junctions (TJs) play an important role in water, ion, and solute transport through the paracellular pathway of epithelial cells; however, their role in diabetes-induced salivary gland dysfunction remains unknown. Here, we found that the TJ proteins
Yan Huang +9 more
doaj +1 more source