Results 231 to 240 of about 78,811 (306)

Reducing Neuroinflammation via Inhibition of Fibrinogen Deposition and Microglial Activation as an Underlying Mechanism of Paning I Decoction in Ameliorating Parkinson's Disease Symptoms

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Paning I decoction alleviated neuroinflammation in Parkinson's disease. ABSTRACT Background Parkinson's disease (PD) is a major neurodegenerative disorder. Some patients show limited response to standard therapies, driving the need for new complementary treatments.
Yan‐Jun Chen, Jing‐Wen Chen, Ming‐Rong Xie, Rui‐Zhen Wang, Yu‐Ling Wan, Jie Zeng, Bing‐Wu Zhong, Sheng‐Qiang Zhou, Fang Liu   +8 more
wiley   +1 more source

Mast cell-derived exosomes and claudin regulation in ulcerative colitis: emerging insights and therapeutic potential. [PDF]

Nanoscale Adv
Li SH, Xu HM, Huang HL, Zhou YJ.
europepmc   +1 more source

Predicting Role of Interleukin‐33 in Determining the Development and Severity of Atopic Dermatitis

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Introduction Atopic dermatitis (AD), also referred to as atopic eczema, is one of the most common immunological disorders in children. Previous studies have suggested potential roles of interleukin‐33 (IL‐33) in the onset and progression of AD.
Ali‐reza Ghasemiyeh, Marzieh Heidarzadeh Arani, Fatemeh Riazian, Ali Aghajani, Mohammad Javad Azadchehr, Hossein Motedayyen   +5 more
wiley   +1 more source

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models. [PDF]

Front Immunol
Xing Y, Shi G, Li Z, Liu X, Nie L, Zhang Y, Song Y, Sun S, Chan MKS, Wong MBF, Casazza K, Lakey JRT, Chen Y, Zhu X, Feng Y.   +14 more
europepmc   +1 more source

GLIS2 Promotes Epithelial‐Mesenchymal Transition and Gastric Cancer Progression by Regulating BGN to Activate the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 2, February 2026.
ABSTRACT This study elucidates the mechanism by which GLIS Family Zinc Finger 2 (GLIS2) promotes epithelial‐mesenchymal transition (EMT) in gastric cancer through biglycan (BGN) activation and Wnt/β‐catenin stimulation. By analyzing 18 pairs of GC tissues and establishing in vitro models (combining GLIS2 knockdown/BGN overexpression with Wnt pathway ...
Juan Yan, Ya‐Peng Deng
wiley   +1 more source

Emerging Breast Cancer Subpopulations: Functional Heterogeneity Beyond the Classical Subtypes. [PDF]

Int J Mol Sci
Kotsifaki A, Kalouda G, Karalexis E, Stathaki M, Metaxas G, Armakolas A.   +5 more
europepmc   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Modulation of SIRT1/PPARγ pathways and tight junction proteins by nicotinamide riboside under chronic variable stress. [PDF]

J Physiol Biochem
Celik A, Sahin N, Orhan C, Er B, Erten F, Ozmen B, Tuzcu M, Ozercan IH, Sahin K.   +8 more
europepmc   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source