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Claudin‐15 forms a water channel through the tight junction with distinct function compared to claudin‐2

Acta Physiologica, 2020
Claudin‐15 is mainly expressed in the small intestine and indirectly involved in glucose absorption. Similar to claudin‐2 and ‐10b, claudin‐15 is known to form a paracellular channel for small cations.
Joerg Piontek   +2 more
exaly   +2 more sources

The Expression of Claudin-1, Claudin-2, Claudin-3, and Claudin-4 in Gastric Cancer Tissue

Journal of Surgical Research, 2011
The claudins (CLDNs) are a family of functional tight junction proteins, and are involved with the epithelial-to-mesenchymal transition (EMT). The claudin proteins have a significant influence on the biological behavior of tumor progression in several types of cancers.
Woo Bae Park, Hyung Min Chin, Hun Jung
exaly   +3 more sources

Piezo1 regulates intestinal epithelial function by affecting the tight junction protein claudin-1 via the ROCK pathway.

Life Science, 2021
AIMS Defective tight junctions (TJs) can induce intestinal epithelial dysfunction, which participates in various diseases such as irritable bowel syndrome. However, the mechanisms of TJ defects remain unclear.
Yudong Jiang   +6 more
semanticscholar   +1 more source

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Science, 2020
A one-two, CAR-T cell punch Chimeric antigen receptor (CAR)–T cells have been clinically effective in killing certain hematological malignancies, but achieving long-term patient responses for solid tumors remains a challenge. Reinhard et al.
Katharina Reinhard   +22 more
semanticscholar   +1 more source

Claudins and nephrolithiasis

Current Opinion in Nephrology and Hypertension, 2018
The greatest risk factor for kidney stone formation is increased urinary calcium excretion. Most filtered calcium is reabsorbed from the proximal tubule and the thick ascending limb (TAL) of Henle's loop via a paracellular pathway. Claudins are tight junction proteins that confer the permeability properties of an epithelium.
Allein, Plain, R Todd, Alexander
openaire   +2 more sources

The role of claudins in homeostasis

Nature Reviews Nephrology, 2023
Sequential expression of claudins, a family of tight junction proteins, along the nephron mirrors the sequential expression of ion channels and transporters. Only by the interplay of transcellular and paracellular transport can the kidney efficiently maintain electrolyte and water homeostasis in an organism.
Luca Meoli, Dorothee Günzel
openaire   +2 more sources

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