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Expression of claudin-7 and loss of claudin-18 correlate with poor prognosis in gastric cancer [PDF]
BackgroundThe purpose of this study was to evaluate the expression of claudin-3, claudin-7, and claudin-18 in gastric cancer and to determine the significance of these proteins for patient outcome.Materials and methodsA total of 134 samples were obtained
Kyong-Hwa Jun
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Cancer Research, 2011
Abstract Claudins are a family of proteins that are structural and functional components of tight junctions and have crucial roles in the maintenance of cellular arrangement, adhesion and paracellular transport. Recent studies have shown that changes and/or loss of claudin expression plays an important role in tumorigenesis and tumor ...
Adriana Bulgarelli +6 more
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Abstract Claudins are a family of proteins that are structural and functional components of tight junctions and have crucial roles in the maintenance of cellular arrangement, adhesion and paracellular transport. Recent studies have shown that changes and/or loss of claudin expression plays an important role in tumorigenesis and tumor ...
Adriana Bulgarelli +6 more
openaire +1 more source
Serum zonulin and claudin-5 levels in patients with bipolar disorder.
Journal of Affective Disorders, 2020BACKGROUND The etiology in bipolar disorder has not been fully understanding. There are limited data regarding the relationship between the permeability of intestinal and blood-brain barrier (BBB), and bipolar disorder etiology.
Faruk Kılıç +4 more
semanticscholar +1 more source
Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF–Resistant Diabetic Macular Edema
Diabetes, 2020Approximately 40% of patients with diabetic macular edema (DME) are resistant to anti–vascular endothelial growth factor (VEGF) therapy (rDME). Here, we demonstrate that significant correlations between inflammatory cytokines and VEGF, as observed in ...
Mitsuru Arima +11 more
semanticscholar +1 more source
Role of claudins in tumorigenesis
Advanced Drug Delivery Reviews, 2005The family of more than 20 claudin (CLDN) proteins comprises one of the major structural elements within the apical tight junction apparatus, a dynamic cellular nexus for maintenance of a luminal barrier, paracellular transport, and signal transduction. Loss of normal tight junction functions constitutes a hallmark of human carcinomas.
Karen, Swisshelm +2 more
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Diverse Regulation of Claudin-1 and Claudin-4 in Atopic Dermatitis
The American Journal of Pathology, 2015Tight junctions are important for skin barrier function. The tight junction protein claudin 1 (Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatitis (AD) patients. In contrast, we did not observe a significant down-regulation of Cldn-1 in nonlesional skin of the AD cohort used in this study. However, for the first time,
Gruber, R. +13 more
openaire +3 more sources
Neuroscience Letters, 2001
The choroid plexus epithelium forms the blood-cerebrospinal fluid (CSF) barrier and is responsible for the secretion of the CSF from the blood. The morphological correlate of the blood-CSF barrier are the tight junctions of choroid plexus epithelium. By freeze-fracture electron microscopy it has been demonstrated that choroid plexus epithelial tight ...
H, Wolburg +3 more
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The choroid plexus epithelium forms the blood-cerebrospinal fluid (CSF) barrier and is responsible for the secretion of the CSF from the blood. The morphological correlate of the blood-CSF barrier are the tight junctions of choroid plexus epithelium. By freeze-fracture electron microscopy it has been demonstrated that choroid plexus epithelial tight ...
H, Wolburg +3 more
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Claudin 18.2 as a novel therapeutic target
Nature Reviews Clinical OncologyI. Nakayama +5 more
semanticscholar +1 more source
Differential Expression of Claudin-1, Claudin-3, and Claudin-4 in Bladder Lesions
Journal of Cancer and Tumor International, 2015Seneldir, Hatice +5 more
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