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Expression of claudin-7 and loss of claudin-18 correlate with poor prognosis in gastric cancer [PDF]

open access: yesInternational Journal of Surgery, 2014
BackgroundThe purpose of this study was to evaluate the expression of claudin-3, claudin-7, and claudin-18 in gastric cancer and to determine the significance of these proteins for patient outcome.Materials and methodsA total of 134 samples were obtained
Kyong-Hwa Jun
exaly   +2 more sources
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Abstract 5009: The expression pattern of claudin-1, claudin-3, claudin-4, claudin-5 and claudin-7 in penile squamous cell carcinoma

Cancer Research, 2011
Abstract Claudins are a family of proteins that are structural and functional components of tight junctions and have crucial roles in the maintenance of cellular arrangement, adhesion and paracellular transport. Recent studies have shown that changes and/or loss of claudin expression plays an important role in tumorigenesis and tumor ...
Adriana Bulgarelli   +6 more
openaire   +1 more source

Serum zonulin and claudin-5 levels in patients with bipolar disorder.

Journal of Affective Disorders, 2020
BACKGROUND The etiology in bipolar disorder has not been fully understanding. There are limited data regarding the relationship between the permeability of intestinal and blood-brain barrier (BBB), and bipolar disorder etiology.
Faruk Kılıç   +4 more
semanticscholar   +1 more source

Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF–Resistant Diabetic Macular Edema

Diabetes, 2020
Approximately 40% of patients with diabetic macular edema (DME) are resistant to anti–vascular endothelial growth factor (VEGF) therapy (rDME). Here, we demonstrate that significant correlations between inflammatory cytokines and VEGF, as observed in ...
Mitsuru Arima   +11 more
semanticscholar   +1 more source

Role of claudins in tumorigenesis

Advanced Drug Delivery Reviews, 2005
The family of more than 20 claudin (CLDN) proteins comprises one of the major structural elements within the apical tight junction apparatus, a dynamic cellular nexus for maintenance of a luminal barrier, paracellular transport, and signal transduction. Loss of normal tight junction functions constitutes a hallmark of human carcinomas.
Karen, Swisshelm   +2 more
openaire   +2 more sources

Diverse Regulation of Claudin-1 and Claudin-4 in Atopic Dermatitis

The American Journal of Pathology, 2015
Tight junctions are important for skin barrier function. The tight junction protein claudin 1 (Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatitis (AD) patients. In contrast, we did not observe a significant down-regulation of Cldn-1 in nonlesional skin of the AD cohort used in this study. However, for the first time,
Gruber, R.   +13 more
openaire   +3 more sources

Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse

Neuroscience Letters, 2001
The choroid plexus epithelium forms the blood-cerebrospinal fluid (CSF) barrier and is responsible for the secretion of the CSF from the blood. The morphological correlate of the blood-CSF barrier are the tight junctions of choroid plexus epithelium. By freeze-fracture electron microscopy it has been demonstrated that choroid plexus epithelial tight ...
H, Wolburg   +3 more
openaire   +2 more sources

Claudin 18.2 as a novel therapeutic target

Nature Reviews Clinical Oncology
I. Nakayama   +5 more
semanticscholar   +1 more source

Differential Expression of Claudin-1, Claudin-3, and Claudin-4 in Bladder Lesions

Journal of Cancer and Tumor International, 2015
Seneldir, Hatice   +5 more
openaire   +2 more sources

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