Results 101 to 110 of about 14,885 (290)

Claudins and hepatocellular carcinoma

Biomedicine & Pharmacotherapy
Hepatocellular carcinoma (HCC) has a high incidence and dismal prognosis, making it a significant global health burden. To change this, the development of new therapeutic strategies is imminent. The claudin (CLDN) family, as key components of tight junctions (TJs), plays an important role in the initiation and development of cancer.
Wentao Wang, Yi Zhou, Wei Li, Chengshi Quan, Yanru Li   +4 more
openaire   +2 more sources

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Self-Assembly Simulations of Classic ClaudinsInsights into the Pore Structure, Selectivity, and Higher Order Complexes

, 2018
Tight junction (TJ) protein assembly controls permeability across epithelial and endothelial cells; thus, biochemical interactions that control the TJ assembly have physiological and biomedical significance.
Sarah R. Willsey (5411087), Nan Wang (21935), Flaviyan Jerome Irudayanathan (1435801), Xiaoyi Wang (90589), Shikha Nangia (1322931), Ian A. Seddon (5411090)   +5 more
core   +2 more sources

EpCAM-claudin-tetraspanin-modulated ovarian cancer progression and drug resistance

Cell Adhesion & Migration, 2020
Alterations of cell adhesion are involved in cancer progression, but the mechanisms underlying the progression and cell adhesion have remained poorly understood. Focusing on the complex between EpCAM, claudins and tetraspanins, we described a sequence of
Zehra Tavsan, Hülya Ayar Kayalı
doaj   +1 more source

Effects of ZO-1 knockout on the localization and expression levels of claudins.

, 2014
(A) Effects of ZO-1 knockout on the localization of claudins. Control and ZO-1 knockout cells of clone 1 were co-cultured on filter inserts. Signal intensity of claudins on lines shown in confocal microscopic images (arrows) were analyzed.
Mikio Furuse (621728), Tomohito Higashi (621727), Shinsaku Tokuda (621726)   +2 more
core   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation [PDF]

, 2006
SummaryA fundamental question in cell and developmental biology is how epithelial cells construct the diffusion barrier allowing them to separate different body compartments.
Furuse, Mikio, Tsukita, Shoichiro, Furuse, Kyoko, Matsui, Takeshi, Sasaki, Hiroyuki, Ikenouchi, Junichi, Nakayama, Mayumi, Katahira-Tayama, Sayaka, Umeda, Kazuaki, Tsukita, Sachiko   +9 more
core   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Chronic Helicobacter pylori-assotiated infection in children, paracellular permeability of the gastric mucosa and food allergy

Zdorovʹe Rebenka, 2019
Currently, issues related to tight junction dysfunction, are one of the most relevant and studied in scientific world. In spite of significant achievements, many problems are still open today.
O.E. Abaturov, A.E. Lykova
doaj   +1 more source

Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells

Advanced Intelligent Systems, EarlyView.
Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer, Chaimae Bahou, Noe Syfrig, Katia Monastyrskaya, Yoan Civet, Ali Hashemi Gheinani, Yves Perriard   +6 more
wiley   +1 more source