Results 51 to 60 of about 94,687 (293)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Research on Dynamic Wear of Revolution Joint with Clearance for Mechanical System
, 2011 In order to study the dynamic wear of revolution joint with clearance in mechanical system, the dynamic model of mechanical system with joint clearance is presented. The clearance model is established based on clearance vector model.
Yang Zhao, Zheng Feng Bai
core +1 more source
Nonlinear Characteristic of Spherical Joints with Clearance
Journal of Aerospace Technology and Management, 2015 Joints in deployable structures can degrade the stiffness and the stability of spacecraft. In this study, the nonlinear stiffness of spherical joints is investigated. The traditional contact model of spherical joints based on non-conforming contact assumption is presented.
Jing, Zhang +3 more
openaire +5 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2014 Single link robotic manipulators are extensively used in industry and research operations. The main design requirement of such manipulators is to minimize link dynamic deflection and its active end vibrations, and obtain high position accuracy during its
Noroozi, Siamak, Dupac, Mihai
core +1 more source
Effect of joint clearance on fatigue strength of brazed joint.
QUARTERLY JOURNAL OF THE JAPAN WELDING SOCIETY, 1989 The effects of joint clearance on fatigue crack initiation life and crack growth rate of brazed joint were investigated.Tes tspecimens used were butt joint of carbon stcel and stainless steel brazed with pure copper with/without an artificial defect in joint.It was inferred from the fatigue test results that fatigue life of joint depend not on crack ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Analysis of dynamic characteristics for momentum wheel assembly with joint clearance
Advances in Mechanical Engineering, 2018 To study the effects of joint clearance on the dynamic characteristics of the momentum wheel assembly of satellite antennas, the computational dynamic model of momentum wheel assembly is developed in this article, considering influencing factors ...
Qi Wan +4 more
doaj +1 more source