Results 61 to 70 of about 309,052 (305)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Transient elastohydrodynamic lubrication analysis of a novel metal-on-metal hip prosthesis with a non-spherical femoral bearing surface

, 2011
Effective lubrication performance of metal-on-metal hip implants only requires optimum conformity within the main loaded area, while it is advantageous to increase the clearance in the equatorial region.
Anissian H.L., Bergmann G., Calonius O., Catelas I., Dobbs H.S., Dowson D., Firkins P.J., Gao LM, Grubl A., Hu X.Q., Jacobs J.J., Lee R., Liu F., Meng Q.E., Meng QE, Rieker C., Skipor A.K., Tuke M.A., Venner C.H., Wang F.C., Yao J.Q.   +20 more
core   +1 more source

Behaviour of pultruded beam-to-column joints using steel web cleats [PDF]

, 2013
Response of pultruded Fibre Reinforced Polymer (FRP) beam-to-column joints with steel bolted web cleats is studied through physical testing. Two joint configurations are considered with either three or two bolts per cleat leg, as per drawings in a ...
Bank, J. Toby Mottram, Jawed Qureshi, Mottram, Mottram, Mottram, Mottram, Qureshi, Turvey, Turvey   +9 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Analysis of dynamic characteristics for momentum wheel assembly with joint clearance

Advances in Mechanical Engineering, 2018
To study the effects of joint clearance on the dynamic characteristics of the momentum wheel assembly of satellite antennas, the computational dynamic model of momentum wheel assembly is developed in this article, considering influencing factors ...
Qi Wan, Geng Liu, Haitao Shi, Xiaofeng Zhang, Xin Ning   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

含运动副间隙的双万向节系统动力学研究

Jixie chuandong, 2012
The solid model of the system of double cardan joint is built through Pro/Engineer,then it is imported into ADAMS to take the dynamic simulation analysis.For the model which does not contain joint clearance,the proper restrain is added according to ...
张辉, 葛文杰, 宁方立, 赵炜
doaj  

5-DOF Dynamic Model of Vehicle Shimmy System with Clearance at Universal Joint in Steering Handling Mechanism

Shock and Vibration, 2013
5-DOF dynamic model of vehicle shimmy system with clearance in universal joint of steering handling mechanism is presented. The sub model of cross shaft universal joint with clearance is built based on Hertz' theory, and two-state model is applied to ...
Jianwei Lu, Yi Xu, Chen Hu, Alexander F. Vakakis, Lawrence A. Bergman   +4 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source