Results 71 to 80 of about 307,462 (307)

Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals [PDF]

, 2017
In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because ...
Caputo, Mariela, Corach, Daniel, Flichman, Diego Martin, Hulaniuk, María L., Trinks, Julieta   +4 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Dynamic Modeling and Analysis of Flexible-Joint Robots with Clearance

Sensors
The coupling effects of flexible joints and clearance on the dynamics of a robotic system were investigated. A numerical analysis was undertaken to reveal the coupling effects between flexible joints and clearance.
Jing Wang, Shisheng Zhou, Jimei Wu, Jiajuan Qing, Tuo Kang, Mingyue Shao   +5 more
doaj   +1 more source

A Modular Low-clearance Wrist Orthosis for Improving Wrist Motion in Children with Cerebral Palsy [PDF]

, 2014
Children with Cerebral Palsy (CP) often exhibit impairments in the coordination of the grip and lift phases of arm movements that directly impact their ability to perform activities of daily living (ADLs).
Beardsley, Scott A., Harris, Gerald F., Holley, Devon, Johnson, Michelle   +3 more
core   +2 more sources

Effect of joint clearance on fatigue strength of brazed joint.

QUARTERLY JOURNAL OF THE JAPAN WELDING SOCIETY, 1989
The effects of joint clearance on fatigue crack initiation life and crack growth rate of brazed joint were investigated.Tes tspecimens used were butt joint of carbon stcel and stainless steel brazed with pure copper with/without an artificial defect in joint.It was inferred from the fatigue test results that fatigue life of joint depend not on crack ...
openaire   +2 more sources

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Dynamic analysis for planar multibody mechanical systems with lubricated joints [PDF]

, 2004
The dynamic analysis of planar multibody systems with revolute clearance joints, including dry contact and lubrication effects is presented here. The clearances are always present in the kinematic joints.
Ambrósio, Jorge, Claro, José Carlos Pimenta, Flores, Paulo   +2 more
core   +1 more source

3D Revolute Joint with Clearance in Multibody Systems [PDF]

, 2017
The aim of this paper is to understand the influence of radial and axial clearance in the revolute joints on the overall performance of a circuit breaker. A circuit breaker mechanism is made of seven links, seven revolute joints with clearance in both radial and axial direction, four unilateral contacts with friction, and it has forty-two degrees of ...
Akhadkar, Narendra, Acary, Vincent, Brogliato, Bernard   +2 more
openaire   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source