Lymphatic blood filling in CLEC-2-deficient mouse models [PDF]
Platelets, 2021 C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventing ...
Elizabeth J Haining +13 more
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Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists [PDF]
Communications Biology, 2023 Fluorescence correlation spectroscopy on crosslinked nanobodies tested on C-type lectin-like receptor 2 (CLEC-2) show different outcomes for divalent and tetravalent nanobody ligands on CLEC-2 clustering, also dependent on CLEC-2 expression levels.
Joanne C. Clark +16 more
doaj +7 more sources
C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes [PDF]
Scientific Reports, 2022 Podoplanin (PDPN) is intensely expressed on the podocyte membrane in an evolutionally conserved manner. CLEC-2, the endogenous ligand of PDPN, is highly expressed in platelets and also exists in a soluble form in plasma.
Keiko Tanaka +6 more
doaj +3 more sources
The Role of CLEC-2 and Its Ligands in Thromboinflammation [PDF]
Frontiers in Immunology, 2021 C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN).
Danyang Meng, Man Luo, Beibei Liu
doaj +5 more sources
Platelet CLEC‐2 and lung development [PDF]
Research and Practice in Thrombosis and Haemostasis, 2020 In this article, the State of the Art lecture “Platelet CLEC‐2 and Lung Development” presented at the ISTH congress 2019 is reviewed. During embryonic development, blood cells are often considered as porters of nutrition and oxygen but not as active ...
Katsue Suzuki‐Inoue, Nagaharu Tsukiji
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Clustering extent‐dependent differential signaling by CLEC‐2 receptors in platelets [PDF]
Research and Practice in Thrombosis and Haemostasis, 2022 Background C‐type lectin receptor family members play a role in many cells including platelets, where they are crucial in the separation of lymphatic and blood vessels during development.
Carol Dangelmaier +4 more
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The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis [PDF]
BMC CancerBackground Podoplanin (PDPN) expressed on tumour cells interacts with platelet C-type lectin-like receptor 2 (CLEC-2). This study aimed to investigate the role of the PDPN-platelet CLEC-2 interaction in melanoma pulmonary metastasis.
Minjia Sheng +3 more
doaj +3 more sources
Evaluation of the podoplanin/C-type lectin-like receptor-2 (CLEC-2) pathway as a mediator of platelet and coagulation activation in sickle cell disease [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Sickle cell disease (SCD) is a condition characterized by a prothrombotic state attributed to the simultaneous activation of hemostasis and innate immunity, referred to as thromboinflammation.
Ivanio Teixeira Borba-Junior +8 more
doaj +3 more sources
Low-dose Btk inhibitors selectively block platelet activation by CLEC-2 [PDF]
Haematologica, 2020 Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2 in ...
Phillip L.R. Nicolson +19 more
doaj +7 more sources
Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2 [PDF]
eLife, 2022 C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji +12 more
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