Results 111 to 120 of about 4,680 (201)

Influence of Hypoxia on a Biomaterial Model of the Bone Marrow Perivascular Niche

Advanced Healthcare Materials, Volume 14, Issue 14, May 28, 2025.
Hypoxia is a key factor in bone marrow physiology and hematopoietic stem cell behavior. Lower oxygen tension influences the secretion of vasculature‐derived hematopoietic regulatory factors and alters hematopoietic cell behavior in a conditioned medium hydrogel model of bone marrow. Cyclosporin A is used to mitigate normoxic stress during hematopoietic
Gunnar B. Thompson, Victoria R. Barnhouse, Sydney K. Bierman, Brendan A.C. Harley   +3 more
wiley   +1 more source

How to perform aggregometry and lumi-aggregometry in mouse platelets [PDF]

, 2018
Light transmission aggregometry (LTA) and lumi-aggregometry are the gold standard platelet assays both clinically and for basic research. The availability of different strains of genetically modified mice, and mouse models of human disease means that ...
Craig E. Hughes, Harrison J, Lages B, Levin J, Longmore GD   +4 more
core   +1 more source

Direct Oral Anticoagulants Are Comparable to Low Molecular Weight Heparin at Sustaining the Circulating Extracellular Vesicle and Inflammatory Profiles of Cancer Associated Thrombosis Patients: An Observational Pilot Study

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Introduction Cancer patients face a 4 to 7‐fold higher risk of developing thrombotic events compared to individuals without cancer. This elevated risk is driven by the underlying tumour biology and the effects of cancer treatments, significantly increasing the mortality rates of these patients.
H. Macleod, N. Copty, D. Doherty, L. Weiss, E. Fouhy, R. Power, N. Ryan, K. Saeed, E. ORourke, R. Faryal, S. Kelliher, B. Kevane, F. Ní Áinle, P. B. Maguire   +13 more
wiley   +1 more source

Об одном из частных вопросов преподавания на кафедре гистологии, цитологии и эмбриологии механизма миграции лимфоцитов через посткапиллярные венулы с высоким эндотелием [PDF]

, 2016
методика преподаванияпреподаваниепедагогические технологиигистология /обучкафедра гистологии, цитологии и эмбриологииЦИТОЛОГИЯ /обучЭМБРИОЛОГИЯ ...
Грушин, В. Н., Кичигина, Т. Н., Лебедева, Е. И., Мяделец, О. Д.   +3 more
core  

Hermansky‐Pudlak Syndrome: From Molecular Pathogenesis to Targeted Therapies

IUBMB Life, Volume 77, Issue 5, May 2025.
ABSTRACT Hermansky‐Pudlak syndrome (HPS) is a rare inherited disorder caused by defects in lysosome‐related organelles (LROs) in various tissues, including platelets, melanocytes, and endothelial cells. Key features of HPS include oculocutaneous albinism, bleeding tendency, and, in some cases, pulmonary fibrosis, granulomatous colitis, and ...
Francesca Tondi, Roberta Annamaria Cirsmaru, Chiara Conti, Antonia Follenzi, Paolo Gresele, Cristina Olgasi, Loredana Bury   +6 more
wiley   +1 more source

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators [PDF]

, 2015
Nucleotide-based drug candidates such as antisense oligonucleotides, aptamers, immunoreceptor-activating nucleotides, or (anti)microRNAs hold great therapeutic promise for many human diseases.
Advani, Al-Tamimi, Alice Y. Pollitt, Andreas Schäfer, Arthur, Bernhard Nieswandt, Bock Lim, Chi, Cognasse, Eckstein, Eelo Gitz, Eisenhardt, Elizabeth E. Gardiner, Gibbins, Gitz, Grüner, Hemmi, Horii, Hu, Iwasaki, Jane F. Arthur, Jung, Karlheinz Peter, Krieg, Krieg, Lennox, Mangin, Marcucci, Maria T.K. Zaldivia, Martine Jandrot-Perrus, Massberg, McKenzie, Michael W. Parker, Nieswandt, Ott, Robert K. Andrews, Schwarz, Semple, Stephanie M. Jung, Tapp, Tracy L. Nero, Ulrike Flierl, van Rooij, Wang, Yu Yao   +44 more
core   +3 more sources

Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments

Aging Cell, Volume 24, Issue 5, May 2025.
We found that reducing insulin signalling in adult worms slows down their reproductive ageing and extends their lifespan without negative side effects. Moreover, combining it with IF further enhances these benefits. These interventions likely work by regulating genes linked to biosynthesis and immunity, showing how optimising gene expression can delay ...
Zahida Sultanova, Aykut Shen, Katarzyna Hencel, Hanne Carlsson, Zoe Crighton, Daniel Clifton, Alper Akay, Alexei A. Maklakov   +7 more
wiley   +1 more source

Integration of Single‐Cell RNA Sequencing Data and Bulk Sequencing Data to Characterise the CD8+ T‐Cell Exhaustion Mediated Immune Microenvironment in CRC

Journal of Cellular and Molecular Medicine, Volume 29, Issue 9, May 2025.
ABSTRACT CD8+ T cells are crucial for the anti‐tumour immune response, and their exhaustion contributes to poor prognosis and limited immunotherapy efficacy in colorectal cancer (CRC). In this study, we examined the immune microenvironment of CRC by integrating single‐cell RNA sequencing (scRNA‐seq) and bulk sequencing data.
Xiao‐Hua Ling, Gang Chen, Nan‐Nan Liu, Wen‐Xin Xu, Ming‐Feng Ding   +4 more
wiley   +1 more source

Platelet signaling: a complex interplay between inhibitory and activatory networks [PDF]

, 2016
The role of platelets in hemostasis and thrombosis is dependent on a complex balance of activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy vasculature suppress platelet activation in the absence of platelet ...
Bye, Alex P., Gibbins, Jon M., Unsworth, Amanda J.   +2 more
core   +1 more source

Modulation of platelet biology with CLEC-2 targeted liposomes [PDF]

, 2022
Christoph Rademacher
openalex   +1 more source