Results 151 to 160 of about 17,655,159 (178)

An overview of the novel platelet activation receptor CLEC-2

Japanese Journal of Thrombosis and Hemostasis, 2009
openaire   +2 more sources

Paramylon isolated from Euglena gracilis EOD-1 extends lifespan through activation of DAF-16-mediated antioxidant pathway via clec-196 in Caenorhabditis elegans. [PDF]

Sci Rep
Higashimura Y, Isobe M, Miura K, Desaka N, Nishikawa H, Nishida N, Naito J, Kawano T, Miyada T, Naito Y.   +9 more
europepmc   +1 more source

Hemostasis-Sparing Antiplatelet Therapy: Current Concepts and Emerging Targets in Arterial Thrombosis. [PDF]

Biomol Ther (Seoul)
Park JW, Oh EB, Chang TS.
europepmc   +1 more source

Structure and function of the CLEC-2 receptor and its ligands

, 2016
Watson, A, Christou, C, Fenton-May, A, O'Callaghan, C   +3 more
openaire   +1 more source

The physiological and pathophysiological roles of platelet CLEC-2 [PDF]

Thrombosis and Haemostasis, 2013
SummaryCLEC-2 is a C-type lectin receptor which is highly expressed on platelets but also found at low levels on different immune cells. CLEC-2 elicits powerful platelet activation upon engagement by its endogenous ligand, the mucin-type glycoprotein podoplanin.
Gérard B Nash, Steve P Watson, Leyre Navarro-Núñez   +2 more
exaly   +4 more sources

RACK1 associates with CLEC-2 and promotes its ubiquitin–proteasome degradation

Biochemical and Biophysical Research Communications, 2009
CLEC-2 is a C-type lectin-like receptor and plays an important role in platelet activation. Snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin are identified as ligands for CLEC-2 and function as stimulators in platelet ...
Yuanyuan Ruan, Liang Guo
exaly   +2 more sources

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CLEC-2-Induced Signaling in Blood Platelets

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2018
Platelet activating receptor CLEC-2 has been identified on platelet surface a decade ago. The only confirmed endogenous CLEC-2 agonist is podoplanin. Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, reticular fibroblastic cells in lymph nodes, kidney podocytes and by cells of certain tumors.
A A, Martyanov, V N, Kaneva, M A, Panteleev, A N, Sveshnikova   +3 more
openaire   +2 more sources

Platelet CLEC-2 and podoplanin in cancer metastasis

Thrombosis Research, 2012
It has long been recognised that the function of platelets in health and disease span far beyond their roles in haemostasis and thrombosis. The observation that tumour cells induce platelet aggregation was followed by extensive experimental evidence linking platelets to cancer progression.
Kate L, Lowe, Leyre, Navarro-Nunez, Stephen P, Watson   +2 more
openaire   +2 more sources

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

Blood, 2009
Abstract Damage to the integrity of the vessel wall leads to exposure of the subendothelial extracellular matrix (ECM), triggering platelet activation and aggregation. This process is essential for primary hemostasis but it may also lead to arterial thrombosis. Although the mechanisms underlying platelet activation on the ECM are well
Frauke, May, Ina, Hagedorn, Irina, Pleines, Markus, Bender, Timo, Vögtle, Johannes, Eble, Margitta, Elvers, Bernhard, Nieswandt   +7 more
openaire   +2 more sources

Fucoidan Is a Novel Platelet Agonist for CLEC-2 Receptor

Blood, 2012
Abstract Abstract 94 Fucoidan, a sulphated polysaccharide from fucus vesiculosus, decreases bleeding time and clotting time in hemophilia, possibly through inhibition of tissue factor pathway inhibitor (TFPI) (Prasad et al., Blood 111:672, 2008).
Bhanukanth Manne, Todd M Getz, Craig Hughes, Carol T Dangelmaier, Steve P Watson, Satya P. Kunapuli   +5 more
openaire   +1 more source