Roles of the CLEC-2–podoplanin interaction in tumor progression
Platelets, 2018 Podoplanin is a type-I transmembrane sialomucin-like glycoprotein expressed on the surface of several kinds of tumor cells. The podoplanin receptor is a platelet activation receptor known as C-type lectin-like receptor 2 (CLEC-2), which has been ...
Katsue Suzuki-Inoue
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Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ. [PDF]
Blood Adv, 2021 Oishi S +11 more
europepmc +3 more sources
Podoplanin and CLEC-2 levels in patients with COVID-19. [PDF]
Res Pract Thromb Haemost, 2023 Podoplanin (PDPN gene) and CLEC-2 are involved in inflammatory hemostasis and have also been related with the pathogenesis of thrombosis. Emerging evidence also suggest that podoplanin can exert protective effects in sepsis and in acute lung injury.
Borba-Junior IT +12 more
europepmc +3 more sources
A minimum valency of 4 is required for robust activation of platelets in flow cytometry by multivalent nanobodies to Glycoprotein VI, C-type lectin-like receptor 2 and Platelet Endothelial Aggregation Receptor 1. [PDF]
Res Pract Thromb HaemostBackgroundWe have reported that tri- and tetravalent nanobodies against GPVI, CLEC-2 and PEAR1 stimulate powerful aggregation and ATP secretion in human platelets.ObjectivesTo evaluate changes in platelet surface glycoproteins elicited by activation of ...
Lamerton RE +5 more
europepmc +3 more sources
Novel platelet activation receptor CLEC-2
Japanese Journal of Thrombosis and Hemostasis, 2011 Katsue Suzuki‐Inoue +2 more
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CLEC-2/podoplanin and thromboinflammation [PDF]
Blood, 2017 In this issue of Blood, Payne et al revealed a novel function of the platelet C–type lectin-like receptor 2 (CLEC-2)/podoplanin interaction in thromboinflammation: podoplanin expression is upregulated in the vessel wall during venous thrombosis. Venous thrombosis is prevented in the absence of CLEC-2.1 The role of platelet CLEC-2 in thromboinflammation
Katsue Suzuki‐Inoue
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Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2
The Journal of biological chemistry, 2010 CLEC-2 has been described recently as playing crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis. The snake venom rhodocytin is known as a strong platelet activator, and we have shown that this effect is mediated by CLEC-2 (Suzuki-Inoue, K., Fuller, G. L., García, A., Eble, J. A., Pöhlmann, S., Inoue, O., Gartner, T.
Katsue Suzuki‐Inoue +12 more
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The roles of platelet clec-2 and podoplanin in skin wound healing [PDF]
, 2019 Platelet-expressed C-type lectin-like receptor-2 (CLEC-2) and glycoprotein (GP)VI play important roles in inflammation, in particular inflammatory haemostasis in the skin.
Surasak Wichaiyo
openalex +2 more sources
New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2. [PDF]
Thromb J, 2016 Ozaki Y, Tamura S, Suzuki-Inoue K.
europepmc +3 more sources
Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis. [PDF]
PLoS ONE, 2015 The platelet receptor CLEC-2 is involved in thrombosis/hemostasis, but its ligand, podoplanin, is expressed only in advanced atherosclerotic lesions. We investigated CLEC-2 ligands in vessel walls.
Osamu Inoue +9 more
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