PLoS ONE, 2013 The platelet aggregation-inducing factor Aggrus, also known as podoplanin, is frequently upregulated in several types of tumors and enhances hematogenous metastasis by interacting with and activating the platelet receptor CLEC-2.
Satoshi Takagi +7 more
doaj +3 more sources
G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2 [PDF]
, 2008 Platelets play an essential role in wound healing by forming thrombi that plug holes in the walls of damaged blood vessels. To achieve this, platelets express a diverse array of cell surface receptors and signaling proteins that induce rapid platelet ...
Jun Mori +7 more
openalex +6 more sources
Platelet CLEC-2: a molecule with 2 faces.
Blood, 2017 In this issue of Blood , Haining et al reveal an unexpected role for platelet C-type lectin-like receptor-2 (CLEC-2) in thrombosis, which is independent of its hemi-immunoreceptor tyrosine-based activation motif (hemITAM) signaling ...
Xia L.
europepmc +4 more sources
Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2 [PDF]
Retrovirology, 2010 Background Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream.
Münch Jan +10 more
doaj +2 more sources
Roles of the CLEC-2–podoplanin interaction in tumor progression
Platelets, 2018 Podoplanin is a type-I transmembrane sialomucin-like glycoprotein expressed on the surface of several kinds of tumor cells. The podoplanin receptor is a platelet activation receptor known as C-type lectin-like receptor 2 (CLEC-2), which has been ...
Katsue Suzuki-Inoue
doaj +4 more sources
A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction. [PDF]
PLoS ONE, 2019 Podoplanin, a transmembrane glycoprotein, is overexpressed in certain types of tumors and induces platelet aggregation by binding to C-type lectin-like receptor 2 (CLEC-2) on the platelet membrane. Activated platelets release granule components, which in
Nobuo Watanabe +10 more
doaj +2 more sources
Functional significance of the platelet immune receptors GPVI and CLEC-2. [PDF]
J Clin Invest, 2019 Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM ...
Rayes J, Watson SP, Nieswandt B.
europepmc +5 more sources
PDGF upregulates CLEC-2 to induce T regulatory cells. [PDF]
Oncotarget, 2015 The effect of platelet derived growth factor (PDGF) on immune cells is not elucidated. Here, we demonstrate PDGF inhibited the maturation of human DCs and induced IL-10 secretion. Culture of PDGF-DCs with T cells induced the polarization of T cells towards FoxP3 expressing T regulatory cells that secreted IL-10.
Agrawal S +4 more
europepmc +7 more sources
A minimum valency of four is required for robust activation of platelets in flow cytometry by multivalent nanobodies to GPVI, CLEC-2 and PEAR1 [PDF]
BackgroundWe have reported that tri- and tetravalent nanobodies against GPVI, CLEC-2 and PEAR1 stimulate powerful aggregation and ATP secretion in human platelets.ObjectivesTo evaluate changes in platelet surface glycoproteins elicited by activation of ...
Rachel E. Lamerton +5 more
openalex +3 more sources
Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases
Platelets, 2021 Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi +4 more
doaj +3 more sources