Results 41 to 50 of about 4,680 (201)

C-type lectin-like receptor 2 in platelets amplifies inflammation in rheumatoid arthritis [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Platelets play a crucial role not only in thrombosis and hemostasis but also in inflammation, including rheumatoid arthritis. Although synovial cells in the joints express the membrane protein podoplanin, and platelets express the podoplanin ...
Tomoyuki Sasaki, Ewelina Golebiewska, Toshiaki Shirai, Nagaharu Tsukiji, Kensuke Koyama, Shogo Tamura, Shimon Otake, Makoto Osada, Hirotaka Haro, Yukio Ozaki, Katsue Suzuki–Inoue   +10 more
doaj   +2 more sources

Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. [PDF]

Blood, 2015
Key PointsPodoplanin and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels. Loss of cerebrovascular integrity is influenced by the loss of αIIb-mediated platelet aggregation and platelet secretion.
Lowe KL, Finney BA, Deppermann C, Hägerling R, Gazit SL, Frampton J, Buckley C, Camerer E, Nieswandt B, Kiefer F, Watson SP.   +10 more
europepmc   +4 more sources

CLEC-2 expression is maintained on activated platelets and on platelet microparticles. [PDF]

Blood, 2014
Key PointsCLEC-2 activation induces proteolytic cleavage of GPVI and FcγRIIa but not itself. CLEC-2 but not GPVI is detected on platelet-derived microparticles.
Gitz E, Pollitt AY, Gitz-Francois JJ, Alshehri O, Mori J, Montague S, Nash GB, Douglas MR, Gardiner EE, Andrews RK, Buckley CD, Harrison P, Watson SP.   +12 more
europepmc   +4 more sources

Cobalt hematoporphyrin inhibits CLEC-2–podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice [PDF]

Blood Adv, 2018
Nagaharu Tsukiji, Makoto Osada, Tomoyuki Sasaki, Toshiaki Shirai, Kaneo Satoh, Osamu Inoue, Norihiko Umetani, Chihiro Mochizuki, Tamio Saito, Soichi Kojima, Hideyuki Shinmori, Yukio Ozaki, Katsue Suzuki‐Inoue   +12 more
openalex   +2 more sources

The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state. [PDF]

Eur J Immunol, 2015
Expression of mouse C‐type lectin‐like receptor 2 (CLEC‐2) has been reported on circulating CD11b(high) Gr‐1(high) myeloid cells and dendritic cells (DCs) under basal conditions, as well as on a variety of leucocyte subsets following inflammatory stimuli
Lowe KL, Navarro-Núñez L, Bénézech C, Nayar S, Kingston BL, Nieswandt B, Barone F, Watson SP, Buckley CD, Desanti GE.   +9 more
europepmc   +4 more sources

Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia [PDF]

Thromb Haemost, 2018
Alexander T. Hardy, Verónica Palma‐Barqueros, Stephanie L. Watson, Jean‐Daniel Malcor, Johannes A. Eble, Elizabeth E. Gardiner, José Eliseo Blanco‐Carnero, Alberto Rafael Guijarro‐Campillo, José Luis Carreras Delgado, Marı́a Luisa Lozano, Raúl Teruel‐Montoya, Vicente Vicente, Steve P. Watson, José Rivera, Francisca Ferrer‐Marín   +14 more
openalex   +2 more sources

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

British Journal of Pharmacology, Volume 182, Issue 16, Page 3838-3851, August 2025.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Di, Helma van den Hurk, Johannes A. Eble, Jonathan M. Gibbins, Ángel Galindo García, Alice Y. Pollitt   +8 more
openalex   +2 more sources

Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis. [PDF]

PLoS ONE, 2015
The platelet receptor CLEC-2 is involved in thrombosis/hemostasis, but its ligand, podoplanin, is expressed only in advanced atherosclerotic lesions. We investigated CLEC-2 ligands in vessel walls.
Osamu Inoue, Kazuya Hokamura, Toshiaki Shirai, Makoto Osada, Nagaharu Tsukiji, Kinta Hatakeyama, Kazuo Umemura, Yujiro Asada, Katsue Suzuki-Inoue, Yukio Ozaki   +9 more
doaj   +1 more source

New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2 [PDF]

Thromb J, 2016
Yukio Ozaki, Shogo Tamura, Katsue Suzuki‐Inoue   +2 more
openalex   +2 more sources

The Association Between Plasma C-Type Lectin Like Receptors 2 (CLEC-2) and STEMI and its Correlation With Clinicolaboratory Data

Egyptian Journal of Critical Care Medicine, 2023
Objectives To assess the association between plasma C-type lectin-like receptor 2 (CLEC-2) and ST elevation myocardial infarction (STEMI) and its correlation with clinicolaboratory data.
Salwa Hassan Ahmed, Ahmed Abd ElMoez ElSayed, Fatma Abdel Wahab Abdel Maksoud, Lamees Mohamed Fathi, Soliman Belal Soliman   +4 more
doaj   +1 more source