Results 41 to 50 of about 4,811 (202)

The Association Between Plasma C-Type Lectin Like Receptors 2 (CLEC-2) and STEMI and its Correlation With Clinicolaboratory Data

Egyptian Journal of Critical Care Medicine, 2023
Objectives To assess the association between plasma C-type lectin-like receptor 2 (CLEC-2) and ST elevation myocardial infarction (STEMI) and its correlation with clinicolaboratory data.
Salwa Hassan Ahmed, Ahmed Abd ElMoez ElSayed, Fatma Abdel Wahab Abdel Maksoud, Lamees Mohamed Fathi, Soliman Belal Soliman   +4 more
doaj   +1 more source

CLEC-2: the inside story. [PDF]

Blood, 2015
Excessive platelet aggregation at sites of atherosclerotic plaque rupture can result in formation of pathological thrombi that reduce or obstruct blood flow to downstream tissues and cause tissue ischemia or infarction.2 Consequently, antiplatelet drugs have been developed for treatment of acute thrombotic events. Platelet activation and aggregation at
Newman DK.
europepmc   +3 more sources

Association of C-type lectin-like receptor 2 and galectin-1 with portal vein system thrombosis in HBV-related liver cirrhosis

Frontiers in Medicine, 2023
Background and aimsHepatitis B virus (HBV) infection is the most common cause of liver cirrhosis. Portal venous system thrombosis (PVST) is a major complication of liver cirrhosis.
Yiyan Zhang, Yiyan Zhang, Xintong Zhang, Xiangbo Xu, Xiangbo Xu, Xiaozhong Guo, Shixue Xu, Shixue Xu, Shaoze Ma, Shaoze Ma, Jihong Chen, Jihong Chen, Xingshun Qi   +12 more
doaj   +1 more source

CLEC-2 activates Syk through dimerization [PDF]

Blood, 2010
AbstractThe C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including phospholipase-C γ2. Signaling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequence in the CLEC-2 cytosolic tail ...
Hughes, C. E., Pollitt, A. Y., Mori, J., Eble, J. A., Tomlinson, Michael G., Hartwig, J. H., O'Callaghan, C. A., Futterer, K., Watson, Steve P   +8 more
openaire   +4 more sources

G_q pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets. [PDF]

J Biol Chem, 2017
Badolia R, Inamdar V, Manne BK, Dangelmaier C, Eble JA, Kunapuli SP.   +5 more
europepmc   +2 more sources

Association between c-type lectin-like receptor 2 and microsatellite instability in colorectal cancer: a cross-sectional study

BMC Cancer, 2022
Background As a transmembrane protein, C-type lectin-like receptor 2 (CLEC-2) is mainly expressed on platelets and released into plasma after platelet activation. Activated platelets participate in the regulation of innate immune cells.
Xin Zhang, Jia-rui Yuan, Xin Wang, Shuang Fu, Rui-tao Wang, Guang-yu Wang   +5 more
doaj   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

Physiological and pathophysiological aspects of blood platelet activation through CLEC-2 receptor

Онкогематология, 2018
Platelet activating receptor CLEC-2 has been identified on platelet surface a decade ago. The only confirmed endogenous CLEC-2 agonist is podoplanin. Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, reticular fibroblastic ...
A. A. Martyanov, V. N. Kaneva, M. A. Panteleev, A. N. Sveshnikova   +3 more
doaj   +1 more source

The structure of CLEC-2: mechanisms of dimerization and higher-order clustering

Platelets, 2021
The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on hemostasis identifying it as a target for a new class of antiplatelet agent.
Eleyna M Martin, Malou Zuidscherwoude, Luis a Morán, Ying Di, Angel García, Steve P Watson   +5 more
doaj   +1 more source

Platelet CLEC-2: a molecule with 2 faces.

Blood, 2017
In this issue of Blood , Haining et al reveal an unexpected role for platelet C-type lectin-like receptor-2 (CLEC-2) in thrombosis, which is independent of its hemi-immunoreceptor tyrosine-based activation motif (hemITAM) signaling ...
Xia L.
europepmc   +4 more sources