Results 51 to 60 of about 4,680 (201)

Association of C-type lectin-like receptor 2 and galectin-1 with portal vein system thrombosis in HBV-related liver cirrhosis

Frontiers in Medicine, 2023
Background and aimsHepatitis B virus (HBV) infection is the most common cause of liver cirrhosis. Portal venous system thrombosis (PVST) is a major complication of liver cirrhosis.
Yiyan Zhang, Yiyan Zhang, Xintong Zhang, Xiangbo Xu, Xiangbo Xu, Xiaozhong Guo, Shixue Xu, Shixue Xu, Shaoze Ma, Shaoze Ma, Jihong Chen, Jihong Chen, Xingshun Qi   +12 more
doaj   +1 more source

An overview of the novel platelet activation receptor CLEC-2

Japanese Journal of Thrombosis and Hemostasis, 2009
Katsue Suzuki‐Inoue
openalex   +4 more sources

Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling [PDF]

, 2010
The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM).
Eble, J. A., Mourao-Sa, D., Nash, C. A., Navarro-Nunez, L., Pollitt, A. Y., Senis, Y. A., Severin, S., Watson, Steve P   +7 more
core   +2 more sources

Association between c-type lectin-like receptor 2 and microsatellite instability in colorectal cancer: a cross-sectional study

BMC Cancer, 2022
Background As a transmembrane protein, C-type lectin-like receptor 2 (CLEC-2) is mainly expressed on platelets and released into plasma after platelet activation. Activated platelets participate in the regulation of innate immune cells.
Xin Zhang, Jia-rui Yuan, Xin Wang, Shuang Fu, Rui-tao Wang, Guang-yu Wang   +5 more
doaj   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

GPVI and CLEC‐2 in hemostasis and vascular integrity [PDF]

Journal of Thrombosis and Haemostasis, 2010
The glycoprotein VI (GPVI)-FcR gamma-chain complex initiates powerful activation of platelets by the subendothelial matrix proteins collagen and laminin through an immunoreceptor tyrosine-based activation motif (ITAM)-regulated signaling pathway. ITAMs are characterized by two YxxL sequences separated by 6-12 amino acids and are found associated with ...
Steve P. Watson, John Herbert, Alice Y. Pollitt   +2 more
openaire   +3 more sources

Physiological and pathophysiological aspects of blood platelet activation through CLEC-2 receptor

Онкогематология, 2018
Platelet activating receptor CLEC-2 has been identified on platelet surface a decade ago. The only confirmed endogenous CLEC-2 agonist is podoplanin. Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, reticular fibroblastic ...
A. A. Martyanov, V. N. Kaneva, M. A. Panteleev, A. N. Sveshnikova   +3 more
doaj   +1 more source

CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP [PDF]

, 2014
The present results demonstrate that platelet adhesion and activation on CLEC-2 ligands or LECs is maintained in the presence of PGI2 and ...
Bazou, Bertozzi, Eble, Emambokus, Finney, Gegenbauer, Grynkiewicz, Herzog, Hughes, Ichise, Kato, Leak, Lowe, Mannheimer, McCarty, Mizuno, Mukherjee, Oguogho, Osada, Pollitt, Rehal, Schacht, Schwarz, Severin, Smolenski, Suzuki-Inoue, Suzuki-Inoue, Watson   +27 more
core   +1 more source

Molecular Analysis of the Interaction of the Snake Venom Rhodocytin with the Platelet Receptor CLEC-2

Toxins, 2011
The Malayan pit viper, Calloselasma rhodostoma, produces a potent venom toxin, rhodocytin (aggretin) which causes platelet aggregation. Rhodocytin is a ligand for the receptor CLEC-2 on the surface of platelets.
Christopher A. O’Callaghan, Aleksandra A. Watson   +1 more
doaj   +1 more source

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
core   +2 more sources