Results 51 to 60 of about 4,811 (202)

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2 [PDF]

, 2008
Platelets play an essential role in wound healing by forming thrombi that plug holes in the walls of damaged blood vessels. To achieve this, platelets express a diverse array of cell surface receptors and signaling proteins that induce rapid platelet ...
Barrow, Bijsterbosch, Blake, Braselmann, Burkhardt, Chen, Christou, Cicmil, Clemetson, Daeron, de Vet, Deindl, Dhanjal, Eble, Ezumi, Fuller, Garcia, Gibbins, Grande, Inazu, Isnardi, Jones, Keren, Lerea, Maeda, Monroe, Moroi, Muraille, Newland, Newton, Nieswandt, Nieswandt, Ono, Patil, Poole, Quek, Ravetch, Reedquist, Roose, Senis, Shapiro, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Takata, Tomlinson, van Oers, Verbrugge, Vivier, Washington, Washington, Watson   +51 more
core   +3 more sources

CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP [PDF]

, 2014
The present results demonstrate that platelet adhesion and activation on CLEC-2 ligands or LECs is maintained in the presence of PGI2 and ...
Bazou, Bertozzi, Eble, Emambokus, Finney, Gegenbauer, Grynkiewicz, Herzog, Hughes, Ichise, Kato, Leak, Lowe, Mannheimer, McCarty, Mizuno, Mukherjee, Oguogho, Osada, Pollitt, Rehal, Schacht, Schwarz, Severin, Smolenski, Suzuki-Inoue, Suzuki-Inoue, Watson   +27 more
core   +1 more source

Podoplanin‐expressing inflammatory macrophages activate murine platelets via CLEC‐2 [PDF]

Journal of Thrombosis and Haemostasis, 2012
Podoplanin, a small transmembrane glycoprotein, is expressed at high levels on lymphatic endothelial cells, kidney podocytes and lung type I alveolar cells, but absent on blood endothelial cells. It has also been described on splenic and peritoneal macrophages, but the functional significance of this is unknown [1].
Kerrigan, A M, Navarro-Nuñez, L, Pyz, E, Finney, B A, Willment, J A, Watson, S P, Brown, G D   +6 more
openaire   +3 more sources

CLEC-2 suppresses calcification in cultured osteoblasts [PDF]

, 2019
AbstractPodoplanin is the only counter-receptor of platelet CLEC-2 and is expressing on mature osteoblast, but there is no report on the role of podoplanin and CLEC-2 in calcification. This study aimed to investigate the role of podoplanin binding to CLEC-2 in the calcification of osteoblasts carrying homozygously deletedPdpnalleles (PdpnΔ/Δ) by ...
Takenori Kanai, Yoshihiko Sawa, Kenyo Takara, Koichiro Kajiwara, Takahiro Fujita, Naruhiko Sawa, Junro Yamashita, Yoshiaki Sato   +7 more
openalex   +2 more sources

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Abtahian, Aguado, Andrews, Auger, Booth, Clements, Clements, Dawood, Eble, Finco, Fuller, Garcia, Hughan, Huysamen, Ishiai, Jordan, Judd, Judd, Kalia, Liu, Liu, McCarty, McCarty, Pasquet, Paz, Perez-Villar, Sarratt, Seet, Shen, Sommers, Suzuki-Inoue, Suzuki-Inoue, Tomlinson, Yablonski, Yablonski, Yoder, Zhang, Zhang, Zhang   +38 more
core   +2 more sources

Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse. [PDF]

Am J Physiol Lung Cell Mol Physiol, 2017
Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP.   +11 more
europepmc   +2 more sources

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
core   +2 more sources

Platelets at the vascular interface [PDF]

, 2018
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Bergmeier, Wolfgang, Stefanini, Lucia
core   +1 more source

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +1 more source

Receptor-Dependent and -Independent Effects of Hemin on Platelet Plasma Membrane Disintegration. [PDF]

FASEB J
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Laspa Z, Rohlfing AK, Hochuli R, Sowa PW, Castor T, Gawaz MP.   +5 more
europepmc   +2 more sources