C-type lectin-like receptors of the dectin-1 cluster : ligands and signaling pathways [PDF]
, 2013 Peer reviewedPublisher ...
Brown, Gordon D +2 more
core +1 more source
GPVI and CLEC‐2 in hemostasis and vascular integrity [PDF]
Journal of Thrombosis and Haemostasis, 2010 The glycoprotein VI (GPVI)-FcR gamma-chain complex initiates powerful activation of platelets by the subendothelial matrix proteins collagen and laminin through an immunoreceptor tyrosine-based activation motif (ITAM)-regulated signaling pathway. ITAMs are characterized by two YxxL sequences separated by 6-12 amino acids and are found associated with ...
S P, Watson +2 more
openaire +2 more sources
Human platelets and their capacity of binding viruses: Meaning and challenges? [PDF]
, 2015 Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to ...
Chabert, Adrien +6 more
core +2 more sources
Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life [PDF]
, 2013 Mammals transport blood through a high-pressure, closed vascular network and lymph through a low-pressure, open vascular network. These vascular networks connect at the lymphovenous (LV) junction, where lymph drains into blood and an LV valve (LVV ...
Bernhard Nieswandt +15 more
core +3 more sources
Microbiology Spectrum, 2023 To initiate an antileishmanial adaptive immune response, dendritic cells (DCs) must carry Leishmania antigens from peripheral tissues to local draining lymph nodes.
Manisha Yadav +7 more
doaj +1 more source
Podoplanin: Emerging Functions in Development, the Immune System, and Cancer [PDF]
, 2012 Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs.
Acton, Sophie E. +2 more
core +1 more source
Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation [PDF]
, 2019 Background Accurate protein quantification is a vital prerequisite for generating meaningful predictions when using systems biology approaches, a method that is increasingly being used to unravel the complexities of sub cellular interactions and as part
Bye, Alexander P. +15 more
core +4 more sources
The physiological and pathophysiological roles of platelet CLEC-2 [PDF]
Thrombosis and Haemostasis, 2013 SummaryCLEC-2 is a C-type lectin receptor which is highly expressed on platelets but also found at low levels on different immune cells. CLEC-2 elicits powerful platelet activation upon engagement by its endogenous ligand, the mucin-type glycoprotein podoplanin.
Leyre, Navarro-Núñez +3 more
openaire +2 more sources
Functional significance of the platelet immune receptors GPVI and CLEC-2. [PDF]
J Clin Invest, 2019 Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM ...
Rayes J, Watson SP, Nieswandt B.
europepmc +4 more sources
Induction of podoplanin by transforming growth factor-β in human fibrosarcoma [PDF]
, 2008 Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential.
Kato Kaneko Mika +7 more
core +1 more source