Results 61 to 70 of about 4,680 (201)

Platelets at the vascular interface [PDF]

, 2018
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Bergmeier, Wolfgang, Stefanini, Lucia
core   +1 more source

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +1 more source

C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice

Platelets, 2023
Kappa-carrageenan (KCG), which is used to induce thrombosis in laboratory animals for antithrombotic drug screening, can trigger platelet aggregation. However, the cell-surface receptor and related signaling pathways remain unclear.
Ryohei Yokomori, Toshiaki Shirai, Nagaharu Tsukiji, Saori Oishi, Tomoyuki Sasaki, Katsuhiro Takano, Katsue Suzuki-Inoue   +6 more
doaj   +1 more source

C-type lectin-like receptors of the dectin-1 cluster : ligands and signaling pathways [PDF]

, 2013
Peer reviewedPublisher ...
Brown, Gordon D, Plato, Anthony, Willment, Janet A   +2 more
core   +1 more source

Human platelets and their capacity of binding viruses: Meaning and challenges? [PDF]

, 2015
Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to ...
Chabert, Adrien, Cognasse, Fabrice, Garraud, Olivier, Gomez, Ricardo Martin, Hamzeh Cognasse, Hind, Pozzetto, Bruno, Schattner, Mirta Ana   +6 more
core   +2 more sources

Leishmania donovani Attenuates Dendritic Cell Trafficking to Lymph Nodes by Inhibiting C-Type Lectin Receptor 2 Expression via Transforming Growth Factor-β

Microbiology Spectrum, 2023
To initiate an antileishmanial adaptive immune response, dendritic cells (DCs) must carry Leishmania antigens from peripheral tissues to local draining lymph nodes.
Manisha Yadav, Md. Naushad Akhtar, Manish Mishra, Sandeep Kumar, Raj Kumar, Shubham, Anil Nandal, Pradip Sen   +7 more
doaj   +1 more source

The Platelet Receptor CLEC-2 Is Active as a Dimer

Biochemistry, 2009
The platelet receptor CLEC-2 binds to the snake venom toxin rhodocytin and the tumor cell surface protein podoplanin. Binding of either of these ligands promotes phosphorylation of a single tyrosine residue in the YXXL motif in the intracellular domain of CLEC-2.
Watson, A., Christou, C., James, J., Fenton-May, A., Moncayo, G., Mistry, A., Davis, S., Gilbert, R., Chakera, Aron, O'Callaghan, C.   +9 more
openaire   +4 more sources

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation [PDF]

, 2019
Background Accurate protein quantification is a vital prerequisite for generating meaningful predictions when using systems biology approaches, a method that is increasingly being used to unravel the complexities of sub cellular interactions and as part
Bye, Alexander P., Di, Ying, Dunster, Joanne L., García, Ángel, Gibbins, Jonathan M., Haining, Elizabeth J,, Hardy, Alexander T., Nieswandt, Bernhard, Pallini, Chiara, Pike, Jeremy A., Pollitt, Alice Y., Poulter, Natalie S., Sage, Tanya, Sowa, Marcin A., Unsworth, Amanda J., Watson, Steve P.   +15 more
core   +3 more sources

CLEC‐2 is not required for platelet aggregation at arteriolar shear [PDF]

Journal of Thrombosis and Haemostasis, 2010
The C-type lectin receptor CLEC-2 is expressed primarily on the surface of platelets, where it is present as a dimer, and is found at low level on a subpopulation of other hematopoietic cells, including mouse neutrophils [1–4] Clustering of CLEC-2 by the snake venom toxin rhodocytin, specific antibodies or its endogenous ligand, podoplanin, elicits ...
Alice Y. Pollitt, Brenda A. Finney, Leyre Navarro-Núñez, Craig E. Hughes, Steve P. Watson, Diego Mourão-Sá   +5 more
openaire   +3 more sources

The novel platelet activation receptor CLEC-2

Platelets, 2011
The c-type lectin-like receptor 2 (CLEC-2) was first identified from a bio-informatic screen for c-type lectin-like receptors. However, neither its function nor its ligand(s) had been elucidated for several years. In 2006, we reported that the receptor is expressed on the surface of platelets and serves as a receptor for the snake venom rhodocytin ...
Osamu Inoue, Yukio Ozaki, Katsue Suzuki-Inoue   +2 more
openaire   +3 more sources