Results 71 to 80 of about 4,811 (202)

The novel platelet activation receptor CLEC-2

Platelets, 2011
The c-type lectin-like receptor 2 (CLEC-2) was first identified from a bio-informatic screen for c-type lectin-like receptors. However, neither its function nor its ligand(s) had been elucidated for several years. In 2006, we reported that the receptor is expressed on the surface of platelets and serves as a receptor for the snake venom rhodocytin ...
Katsue, Suzuki-Inoue, Osamu, Inoue, Yukio, Ozaki   +2 more
openaire   +2 more sources

Novel platelet activation receptor CLEC‐2: from discovery to prospects [PDF]

Journal of Thrombosis and Haemostasis, 2011
C-type lectin-like receptor 2 (CLEC-2) has been identified as a receptor for the platelet activating snake venom rhodocytin. CLEC-2 elicits powerful platelet activation signals in conjunction with Src, Syk kinases, and phospholipase Cγ2, similar to the collagen receptor glycoprotein (GP) VI/FcRγ-chain complex.
K, Suzuki-Inoue, O, Inoue, Y, Ozaki
openaire   +2 more sources

Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2

Retrovirology, 2010
Background Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream.
Münch Jan, Schmökel Jan, Kato Yukinari, Glowacka Ilona, Bertram Stephanie, Tsegaye Theodros, Steffen Imke, Chaipan Chawaree, Simmons Graham, Gerardy-Schahn Rita, Pöhlmann Stefan   +10 more
doaj   +1 more source

Functional and Homeostatic impact of Age-Related Changes in Lymph node Stroma [PDF]

, 2017
Adults over 65 years of age are more vulnerable to infectious disease and show poor responses to vaccination relative to those under 50. A complex set of age-related changes in the immune system is believed to be largely responsible for these defects ...
Nikolich-Zugich, Janko, Smithey, Megan J., Surh, Charles D., Thompson, Heather L.   +3 more
core   +2 more sources

Crystallization and X-ray diffraction analysis of human CLEC-2 [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2005
The human C-type lectin-like protein CLEC-2 has recently been shown to be expressed on the surface of platelets and to function as a receptor for the snake-venom protein rhodocytin. The C-type lectin-like domain (CTLD) of CLEC-2 was expressed in Escherichia coli, refolded and purified.
Watson, A, O'Callaghan, C
openaire   +2 more sources

Thrombomodulation via CLEC-2 targeting

Current Opinion in Pharmacology, 2009
CLEC-2 is a C-type lectin-like molecule that has recently been identified as a receptor on the surface of platelets. Ligand binding by CLEC-2 promotes phosphorylation of a tyrosine in the cytoplasmic domain YXXL motif of CLEC-2 by Src kinases and further downstream signalling events trigger platelet activation and aggregation.
openaire   +3 more sources

Elevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome

Clinical and Applied Thrombosis/Hemostasis, 2022
Podoplanin (PDPN) promotes platelet aggregation and activation by interacting with C-type lectin-like receptor 2(CLEC-2) on platelets. The interaction between the upregulated PDPN and platelet CLEC-2 stimulates venous thrombosis. PDPN was identified as a
Ying Ji MD, Yan-Li Wang MD, Fang Xu MS, Xi-Bei Jia MD, Su-Hong Mu MD, Hui-Yan Lyu PhD, Xue-Ying Yuan PhD, Shi-Ping Na MD, Yu-Shi Bao PhD   +8 more
doaj   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source

An IQ Consortium Perspective on the FDA Guidance for Assessment of Pharmacokinetics in Participants With Impaired Renal Function

Clinical Pharmacology &Therapeutics, EarlyView.
The FDA published guidance on assessing pharmacokinetics (PK) in participants with impaired renal function in 2024. The IQ CPLG Organ Impairment Working Group summarized the industry’s perspective on this guidance by highlighting a few key updates in the 2024 guidance, including: (1) the recommendation of using estimated glomerular filtration rate ...
Yan Jin, Ashish Sharma, Mariam A. Ahmed, Sravanthi Cheeti, Ying Ou, Damayanthi Devineni, Yizhe Chen, Jitendra S. Kanodia, Yasmeen Abouelhassan, Nadia Noormohamed, Jin Zhou, Patrick Marroum, Vaishali Sahasrabudhe, Islam R. Younis   +13 more
wiley   +1 more source

Identification of platelet function defects by multi-parameter assessment of thrombus formation. [PDF]

, 2014
Assays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi-parameter flow assay to characterize thrombus formation in whole blood from ...
Baaten, Constance, Cavill, Rachel, Clemetson, Kenneth J, Coort, Susan, Cosemans, Judith MEM, de Witt, Susanne M, Farndale, Richard W, Heemskerk, Johan WM, Jurk, Kerstin, Lamers, Moniek ME, Mastenbroek, Tom, Pugh, Nicholas, Scharrer, Inge, Schulz, Ansgar, Swieringa, Frauke, van Kruchten, Roger, Zieger, Barbara   +16 more
core   +4 more sources