Results 71 to 80 of about 4,680 (201)
CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION [PDF]
, 2015 Platelets are involved in many processes ranging from fighting microbial infections and triggering inflammation to promoting tumor angiogenesis and metastasis. Nevertheless, the primary physiological function of platelets is to act as essential mediators
Manne, Bhanu Kanth
core +1 more source
Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life [PDF]
, 2013 Mammals transport blood through a high-pressure, closed vascular network and lymph through a low-pressure, open vascular network. These vascular networks connect at the lymphovenous (LV) junction, where lymph drains into blood and an LV valve (LVV ...
Bernhard Nieswandt +15 more
core +3 more sources
CLEC-2 suppresses calcification in cultured osteoblasts [PDF]
, 2019 AbstractPodoplanin is the only counter-receptor of platelet CLEC-2 and is expressing on mature osteoblast, but there is no report on the role of podoplanin and CLEC-2 in calcification. This study aimed to investigate the role of podoplanin binding to CLEC-2 in the calcification of osteoblasts carrying homozygously deletedPdpnalleles (PdpnΔ/Δ) by ...
Kanai, Takenori +7 more
openaire +2 more sources
Podoplanin: Emerging Functions in Development, the Immune System, and Cancer [PDF]
, 2012 Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs.
Acton, Sophie E. +2 more
core +1 more source
CLEC-2 is required for development and maintenance of lymph nodes [PDF]
Blood, 2014 Key Points CLEC-2 is necessary for lymphatic cell proliferation and lymph node anlage persistence after birth. Lack of CLEC-2 expression on megakaryocytes and platelets compromises lymph node integrity in adult life.
Steve P. Watson +10 more
openaire +3 more sources
Induction of podoplanin by transforming growth factor-β in human fibrosarcoma [PDF]
, 2008 Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential.
Kato Kaneko Mika +7 more
core +1 more source
Elevated Soluble Podoplanin Associates with Hypercoagulability in Patients with Nephrotic Syndrome
Clinical and Applied Thrombosis/Hemostasis, 2022 Podoplanin (PDPN) promotes platelet aggregation and activation by interacting with C-type lectin-like receptor 2(CLEC-2) on platelets. The interaction between the upregulated PDPN and platelet CLEC-2 stimulates venous thrombosis. PDPN was identified as a
Ying Ji MD +8 more
doaj +1 more source
Functional and Homeostatic impact of Age-Related Changes in Lymph node Stroma [PDF]
, 2017 Adults over 65 years of age are more vulnerable to infectious disease and show poor responses to vaccination relative to those under 50. A complex set of age-related changes in the immune system is believed to be largely responsible for these defects ...
Nikolich-Zugich, Janko +3 more
core +2 more sources
Thrombomodulation via CLEC-2 targeting
Current Opinion in Pharmacology, 2009 CLEC-2 is a C-type lectin-like molecule that has recently been identified as a receptor on the surface of platelets. Ligand binding by CLEC-2 promotes phosphorylation of a tyrosine in the cytoplasmic domain YXXL motif of CLEC-2 by Src kinases and further downstream signalling events trigger platelet activation and aggregation.
openaire +4 more sources
Recipe for Hydrogels With Tunable Relaxation and Diffusion Properties for Use as MRI Test Materials
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose To develop and evaluate a preparation protocol (recipe) for hydrogels with specific relaxation times and ADC values to be used as tissue‐like test materials for MRI experiments at 3 Tesla. Methods Gd‐DTPA, agarose, and soy lecithin were used as modulators for T1, T2, and ADC.
V. Fritz, F. Schick
wiley +1 more source