Results 81 to 90 of about 4,680 (201)

Crystallization and X-ray diffraction analysis of human CLEC-2 [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2005
The human C-type lectin-like protein CLEC-2 has recently been shown to be expressed on the surface of platelets and to function as a receptor for the snake-venom protein rhodocytin. The C-type lectin-like domain (CTLD) of CLEC-2 was expressed in Escherichia coli, refolded and purified.
Watson, A, O'Callaghan, C
openaire   +3 more sources

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

The FEBS Journal, EarlyView.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef M. Penninger   +10 more
wiley   +1 more source

From Multicultural Experiment to Performing “China's Story”: Complying With Shifting Norms at a Chinese–Hungarian Bilingual School

Regulation &Governance, EarlyView.
ABSTRACT Adopting a broad understanding of compliance as adherence to norms, this study examines the role of the Chinese–Hungarian Bilingual School in Budapest in the propagation of institutional, educational, and civic norms, through an anthropological inquiry into the discourses and practices embraced and enacted by teachers, parents, and students ...
Fanni Beck, Pál Nyíri
wiley   +1 more source

C-type lectin-like receptor 2: roles and drug target

Thrombosis Journal
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocytin, respectively.
Lan Sun, Zhe Wang, Zhiyan Liu, Guangyan Mu, Yimin Cui, Qian Xiang   +5 more
doaj   +1 more source

Das Hühner CLEC-2 Homolog [PDF]

, 2012
Das Hühner CLEC-2 Homolog: Ein Thrombozytenrezeptor mit aktivierender Funktion Der Natürliche Killer Gen Komplex (NKC) des Huhnes ist auf dem Chromosom 1 lokalisiert und weist zwei C-typ Lektine auf, von denen das eine als Homolog zu CD69 und das andere
Neulen, Marie-Luise
core  

Host Transcriptomics Reveal Reduction in Defence‐Reproduction Trade‐Offs During Coinfection

Molecular Ecology, Volume 34, Issue 21, November 2025.
ABSTRACT During infection, hosts may shift resources away from reproduction towards immune defence. It is unclear to what degree these costly trade‐offs can be alleviated during protective coinfections, whereby antagonism between parasites reduces disease severity. We used transcriptomics to assess the extent to which host gene expression reflected the
Ian Will, Emily J. Stevens, Kayla C. King, Kieran A. Bates   +3 more
wiley   +1 more source

Germinal center formation is resilient to CD69 deletion on T follicular helper cells

Immunology &Cell Biology, Volume 103, Issue 9, Page 844-856, October 2025.
CD69 is upregulated on human and mouse CD4+ T follicular helper (TFH) cells within the germinal center. In this article, we use an Il21‐cre mouse strain to ablate floxed Cd69 genes from TFH cells and a proportion of their precursors. We find that when TFH cells lack CD69, the germinal center response remains intact, supporting B‐cell affinity ...
Stephane M Guillaume, Helena A Carslaw, Silvia Innocentin, Louise M C Webb, Adrian Liston, William S Foster, Michelle A Linterman   +6 more
wiley   +1 more source

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

eJHaem, 2021
All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK‐1026.
Bibian M.E. Tullemans, Mieke F.A. Karel, Valentine Léopold, Marieke S. ten Brink, Constance C.F.M.J. Baaten, Sanne L. Maas, Alex F. deVos, Johannes A. Eble, Marten R. Nijziel, Emiel P.C. van derVorst, Judith M.E.M. Cosemans, Johan W.M. Heemskerk, Theodora A.M. Claushuis, Marijke J.E. Kuijpers   +13 more
doaj   +1 more source

A Critical Review on BH3 Mimetic Drugs and the Treatment of Cancer‐Associated Thrombosis (CAT): A Proposed Design for a Drug Delivery System Capable of Simultaneously Targeting Tumor Cells and Activated Platelets

Cancer Medicine, Volume 14, Issue 18, September 2025.
Targeting Cancer associated thrombosis (CAT): The left panel (A) shows cancer‐associated thrombosis with activated platelets expressing αIIbβ3 in close contact with tumoral vasculature expressing αvβ3 integrin, where both cells release a significant amount of thrombin.
Mehran Ghasemzadeh, Nazanin Heidari, Jalal Naghinezhad, Alireza Ghasemzadeh, Ehteramolsadat Hosseini   +4 more
wiley   +1 more source

Investigating the Prospect of C-Type Lectin-like Receptors-2 for Predicting Prognosis of Ischemic Stroke: Rapid Review of Molecular Mechanisms to Clinical Study

Majalah Biomorfologi
Highlights • The potential of CLEC-2 as a prognostic biomarker for ischemic stroke is supported by in vivo and clinical studies demonstrating its role in thrombo-inflammatory mechanisms and clinical outcome prediction.
Rayhan Farandy, Muhammad Ilham Dhiya Rakasiwi, Muhammad Zaki Bariz Amaanullah, Nurul Gusti Khatimah   +3 more
doaj   +1 more source