Results 21 to 30 of about 463 (171)

Diterpene Foliar Exudates of and Phytotoxicity of Clerodanes

Natural Product Communications, 2014
Blakiella bartsiifolia (S.F. Blake), an endemic and rare high altitude plant of the northern Andes, appears well adapted to the prevailing harsh environment owing in part to a thick glandular trichome cover.
Diego Rodriguez-Hernandez, Alberto Oliveros-Bastidas, Miguel E. Alonso-Amelot, Maria Pia Calcagno-Pissarelli   +3 more
doaj   +1 more source

Ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex Hutch. and Assessment of Their Cytotoxicity against Human Cancer Cell Lines

Molecules, 2018
New clerodane diterpenes, 12-epi-megalocarpodolide D (2) and an epimeric mixture of crotonolins A (3) and B (4), were isolated from the bark of Croton oligandrus following a bioassay-guided isolation protocol. Known compounds, megalocarpodolide D (1), 12-
Stephanie Tamdem Guetchueng, Lutfun Nahar, Kenneth James Ritchie, Fyaz Mahmood Daud Ismail, Andrew Robert Evans, Satyajit Dey Sarker   +5 more
doaj   +1 more source

Genus Cistus: a model for exploring labdane-type diterpenes' biosynthesis and a natural source of high value products with biological, aromatic and pharmacological properties

Frontiers in Chemistry, 2014
The family Cistaceae (Angiosperm, Malvales) consists of 8 genera and 180 species, with 5 genera native of the Mediterranean area (Cistus, Fumara, Halimium, Helianthemum and Tuberaria).
Dimitra ePapaefthimiou, Antigoni ePapanikolaou, Vasiliki eFalara, Stella eGivanoudi, Stefanos eKostas, Angelos K. Kanellis   +5 more
doaj   +1 more source

Stereocontrolled Synthesis of the cis-Hydroxydecalin System: Towards Biologically Active 19-nor-Clerodanes

, 2012
The 19-nor-clerodanes are compact, densely functionalized diterpenes based on a stereocentre-rich decalin scaffold. To date only a few examples of the 19-nor-clerodanes have been synthesized, hence new flexible strategies are required. We herein describe
Pouwer, Rebecca H., V. Bernhardt, Paul, Craig M. Williams, Williams, Craig M., Paul Malek Mirzayans, Mirzayans, Paul Malek, Bernhardt, Paul V., Rebecca H. Pouwer, Paul V. Bernhardt   +8 more
core   +1 more source

Discovery of neo-Clerodane Diterpenoids from Ajuga campylantha as Neuroprotective Agents against Ferroptosis and Neuroinflammation

, 2023
Twelve new neo-clerodane diterpenoids, eight undescribed methoxy/ethoxy acetal analogues, and one new nor-iridane monoterpenoid were isolated from Ajuga campylantha.
Zhikang Zhang (6499571), Huihao Zhou (3135732), Qingyun Tan (6069671), Deyin Wu (1311384), Xing Peng (3874045), Jun Xu (45543), Qiong Gu (562902)   +6 more
core   +3 more sources

New neo-Clerodanes fromTinnea antiscorbutica Welv

, 2013
Three new neo-clerodanes, antiscorbuticane A, antiscorbuticane B and antiscorbuticane C, and known compounds glutinol, friedelin, 5,7-dihydroxyflavanone (pinocembrin), 5-hydroxy-3,6,7,4'-tetramethoxyflavone, 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone ...
Rueff, José, Gaspar, Jorge F., Mendonça, Dina, Mendonça, António, Diakanamwa, Carlos, Vieira, Liliana, Borges, Cristina M. P., Pinheiro, Sandra C. S., Martins, Célia   +8 more
core   +1 more source

Pharmacokinetics and Tissue Distribution in Rats After Oral Administration of Tibetan Medicine Wuwei Leze Powder

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Wuwei Leze Powder (WLP), a classic Tibetan medicine for rheumatoid arthritis, is orally administered and undergoes extensive absorption and metabolism in rats. A total of 56 plasma constituents, including 21 prototypes and 35 metabolites, are identified.
Ping Wang, Peng Wang, YiRui Wu, ShuiYing Wu, HuiJuan Xu, WenYu Yang, Ya Tu, Chuan Liu   +7 more
wiley   +1 more source

Oral Copaiba Oil‐Resin Supplementation Reduces Plasma and Hepatic Oxidative Stress in Female and Male Hypothalamic‐Obese Animals

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Oral supplementation with copaiba‐oil resin (Co‐resin) restores hepatic and plasma oxidative systems in hypothalamic‐obese male and female rats, therefore, it showed a more positive impact on females. This study highlights the therapeutic potential of Co‐resin to reduce reactive oxygen species production and restore plasma and hepatic antioxidant ...
Sirlei P. Souza, Zoé M. N. de Carvalho, Beatriz M. Daudt, Marianela A. F. Urrutia, Caroline M. Aguiar, Ellen C. Z. Gomes, Mustafa M. M. Dahleh, Marina Prigol, Gustavo P. Guerra, Lucinéia F. C. Ribeiro, Sabrina Grassiolli   +10 more
wiley   +1 more source

Total synthesis of 1,2,11,12E-tetradehydrohardwickiic acid

Tetrahedron Chem
Clerodane diterpenoids are a large class of natural products found in various species and exhibit a wide range of biological activities. trans-Clerodanes, which feature a trans-decalin core structure, are the most common subfamily of clerodane ...
Wenming Zhu, Duo Zhang, Yucheng Li, Ming Yang   +3 more
doaj   +1 more source

Discovery of VEGFR‐2 Inhibitors From Leonurus japonicus via Integrated Genetic Authentication, Molecular Networking, and In Silico Analysis

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
Genetic authentication of Leonurus japonicus was confirmed using ITS sequencing. UHPLC‐MS/MS‐GNPS analysis and isolation led to a new labdane diterpenoid (1) and known compounds (2–6), with anti‐angiogenic activity validated by EPC assays and VEGFR‐2 docking studies.
Thiyagarajan Raviraj, Chen‐Lin Yu, Aekkhaluck Intharuksa, Shang‐Chih Lai, Vidya Febrasca Tenderly, Yen Chi Loo, Pin‐Wei Chen, Shih‐Wei Wang, Kartiko Arif Purnomo, Soundar Rajan Kulandhaivel, Sedin Renadi, Stephen Lirio, Yuan‐Bin Cheng, Yu‐Liang Yang, Tsong‐Long Hwang, Fang‐Rong Chang, Michal Korinek   +16 more
wiley   +1 more source