Click Chemistry and Radiochemistry: An Update
Bioconjugate Chemistry, 2023 The term “click chemistry” describes a class of organic transformations that were developed to make chemical synthesis simpler and easier, in essence allowing chemists to combine molecular subunits as if they were puzzle pieces.
David Bauer +4 more
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Click Chemistry for Biofunctional Polymers: From Observing to Steering Cell Behavior. [PDF]
Chem RevClick chemistry has become one of the most powerful construction tools in the field of organic chemistry, materials science, and polymer science, as it offers hassle-free platforms for the high-yielding synthesis of novel materials and easy ...
Ghosal K +3 more
europepmc +2 more sources
Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications. [PDF]
Bioconjug ChemClick chemistry has become a commonly used synthetic method due to the simplicity, efficiency, and high selectivity of this class of chemical reactions. Since their initial discovery, further click chemistry methods have been identified and added to the ...
Luu T, Gristwood K, Knight JC, Jörg M.
europepmc +2 more sources
Click Chemistry: Diverse Chemical Function from a Few Good Reactions [PDF]
Angewandte Chemie, 2001 Hartmuth C. Kolb +2 more
openalex +2 more sources
Cavity Click Chemistry: Cavity-Catalyzed Azide-Alkyne Cycloaddition. [PDF]
Journal of Physical Chemistry A, 2023 Click chemistry, which refers to chemical reactions that are fast and selective with high product yields, has become a powerful approach in organic synthesis and chemical biology.
Fabijan Pavošević +2 more
semanticscholar +1 more source
Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Click chemistry reactions constitute an important and relatively new approach in the medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms of overcoming the limitations of facile chemical synthesis, increased ...
A. Angeli, C. Supuran
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Recent Advancements in Triazole-based Click Chemistry in Cancer Drug Discovery and Development
SynOpen, 2023 Triazole-based compounds possess a broad range of activity and can be synthesized using click chemistry. Many new chemotherapeutic agents have been developed in recent years by exploiting click chemistry and these are covered in this review.
Arun Kumar +3 more
semanticscholar +1 more source
Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists?
ChemMedChem, 2023 Click chemistry is universally recognized as a powerful strategy for the fast and precise assembly of diverse building blocks. Targeted Protein Degradation (TPD) is a new therapeutic modality based on heterobifunctional small‐molecule degraders that ...
Anna Pasieka +3 more
semanticscholar +1 more source
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 [PDF]
, 2011 We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays.
Agnew, Heather D. +12 more
core +2 more sources
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Nature Communications, 2017 Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases.
A. Bhardwaj, J. Kaur, M. Wuest, F. Wuest
semanticscholar +1 more source