Results 251 to 260 of about 1,290,910 (349)

LC-MS and High-Throughput Data Processing Solutions for Lipid Metabolic Tracing Using Bioorthogonal Click Chemistry. [PDF]

Angew Chem Int Ed Engl
Nepachalovich P, Bonciarelli S, Lombardi Bendoula G, Desantis J, Eleuteri M, Thiele C, Goracci L, Fedorova M.   +7 more
europepmc   +1 more source

Watching the Slideshow [PDF]

, 2014
Johnson, Justine
core   +1 more source

EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib‐Resistant Lung Cancer Therapy

Advanced Science, EarlyView.
In this study, an EGFR lipoSM PROTACs (GM‐protac), which can achieve efficient EGFR degradation and HDACi delivery, is developed. It is found that GM‐protac can both block EGFR‐dependent pathways and bypass the HDAC signaling pathway. Meanwhile, both display obvious tumor inhibition with negligible toxicity in EGFR‐TKI‐resistant lung cancer animal ...
Dongyuan Wang, Yajing Liu, Ying Chen, Chuan Dai, Wenzhu Hu, Jinyan Han, Zigang Li, Feng Yin, Yu Zhang, Chen Shi   +9 more
wiley   +1 more source

Hybrid Uracil Derivatives with Caffeine and Gramine Obtained via Click Chemistry as Potential Antioxidants and Inhibitors of Plant Pathogens. [PDF]

Molecules
Szlaużys M, Ostrowski K, Nowak D, Prukała W, Starzyk J, Jasiewicz B, Mrówczyńska L.   +6 more
europepmc   +1 more source

Steric‐Adaptive Biocatalysis: Imine Reductase‐Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines

Advanced Science, EarlyView.
An unusual IRED platform is reported, enabling efficient DKR via reductive amination without any evolutionary engineering. The system accommodates extremely sterically demanding substrates, including naphthyl and quinoline derivatives, delivering naphthyl‐aryl and quinoline‐aryl amine atropisomers with excellent efficiency and stereocontrol (over 80 ...
Zhichao Ni, Jingyuan Zhuang, Yadong Gao, Guangsheng Gao, Zhenling Liu, Ping Su, Gui‐Juan Cheng, Li‐Cheng Yang   +7 more
wiley   +1 more source

Protocol for the visualization and identification of S-palmitoylated proteins in HCT-116 cells using metabolic labeling via click chemistry. [PDF]

STAR Protoc
Merz N, Grösch S.
europepmc   +1 more source

Millikelvin Intracellular Nanothermometry with Nanodiamonds

Advanced Science, EarlyView.
Nanothermometry in living cells is crucial for understanding heat diffusion and advancing cellular biology and drug discovery. Previous studies have reported controversial intracellular temperature variations. Using nanodiamond nanothermometry in macrophages, it is found that, in such experimental setting, apparent temperature changes are actually due ...
Maabur Sow, Jacky Mohnani, Genko Genov, Raphael Klevesath, Elisabeth Mayerhoefer, Yuliya Mindarava, Rémi Blinder, Soumen Mandal, Fabien Clivaz, Raúl B. Gonzalez, Daniel Tews, Christian Laube, Wolfgang Knolle, Amelie Jerlitschka, Farid Mahfoud, Oleg Rezinkin, Mateja Prslja, Yingke Wu, Pamela Fischer‐Posovszky, Martin B. Plenio, Susana F. Huelga, Tanja Weil, Anke Krueger, Gavin W. Morley, Oliver A. Williams, Steffen Stenger, Fedor Jelezko   +26 more
wiley   +1 more source

Gemcitabine-Doxorubicin Combination Polymer-Drug Conjugate Prepared by SPAAC Click Chemistry: In Vitro Characterization. [PDF]

Int J Mol Sci
Gbadegesin OD, Adesina SK.
europepmc   +1 more source

An Injectable Zwitterionic Hydrogels with Multiple Intermolecular Interactions for Effective Prevention of Abdominal Adhesions

Advanced Science, EarlyView.
An injectable PSA‐ZnO through multiple intermolecular including hydrogen bonds and electrostatic interactions for effectively prevents abdominal adhesions. The PSA‐ZnO hydrogel demonstrates superior wound healing promotion (≥ 95%) and more effective inhibition of scar formation compared to the commercial 3M dressing (≈80%), and prevents post‐operative ...
Na Wen, Yating Jiang, Yunhao Song, Jiachao Yang, Jinlin Long, Ying Wang, Xunbin Yu, Shiyun Lu, Tianhua Zhou, Xueping Huang   +9 more
wiley   +1 more source

Integrating PLOR and SPAAC Click Chemistry for Efficient Site-Specific Fluorescent Labeling of RNA. [PDF]

Int J Mol Sci
Xue Y, Si X, Yin D, Zhang S, Dai H.
europepmc   +1 more source