Recent Advancements in Triazole-based Click Chemistry in Cancer Drug Discovery and Development
SynOpen, 2023 Triazole-based compounds possess a broad range of activity and can be synthesized using click chemistry. Many new chemotherapeutic agents have been developed in recent years by exploiting click chemistry and these are covered in this review.
Arun Kumar +3 more
doaj +1 more source
Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Click chemistry reactions constitute an important and relatively new approach in the medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms of overcoming the limitations of facile chemical synthesis, increased ...
Andrea Angeli, Claudiu T. Supuran
doaj +1 more source
Heterogeneous Photocatalytic Click Chemistry [PDF]
Journal of the American Chemical Society, 2016 Copper-doped semiconductors are designed to photoassist the alkyne-azide cycloaddition catalysis by Cu(I). Upon irradiation, injection of electrons from the semiconductor into copper oxide nanostructures produces the catalytic Cu(I) species. The new catalysts are air- and moisture-tolerant and can be readily recovered after use and reused several times.
Wang, Bowen +4 more
openaire +4 more sources
Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists? [PDF]
, 2023 Click chemistry is universally recognized as a powerful strategy for the fast and precise assembly of diverse building blocks. Targeted Protein Degradation (TPD) is a new therapeutic modality based on heterobifunctional small-molecule degraders that ...
Diamanti, Eleonora +3 more
core +1 more source
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 [PDF]
, 2011 We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays.
Agnew, Heather D. +12 more
core +2 more sources
Application of click chemistry in nanoparticle modification and its targeted delivery
Biomaterials Research, 2018 Background Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative ...
Gawon Yi +4 more
doaj +1 more source
Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications
SynOpen, 2023 This short review describes the assistance of click chemistry in the chemical modification of glycosaminoglycans. Through an alkyne-azide 1,3-dipolar cycloaddition reaction, the chemically and physiologically stable triazole unit connects ...
Smritilekha Bera, Dhananjoy Mondal
doaj +1 more source
Tunable BODIPY derivatives amenable to "click" and peptide chemistry [PDF]
, 2013 Novel azido- and amino- functionalised fluorescent probes based on the BODIPY framework have been developed. The probes can be easily and cheaply synthesised, exhibit the highly desirable BODIPY fluorescent properties, and are amenable to “click” and ...
Gadegaard, N. +5 more
core +1 more source
Functionalization of chitosan by click chemistry [PDF]
AIP Conference Proceedings, 2017 Chitosan modification represents a challenge nowadays. The variety of compounds which can be obtained with various architectures and different functionalities made it attractive to be used in fields like pharmacy and material science. Presents study deals with the chemical modification of chitosan by using click chemistry technique.
Cheaburu-Yilmazi, Catalina Natalia +2 more
openaire +5 more sources
Supramolecular aggregation control in polyoxometalates covalently functionalized with oligoaromatic groups [PDF]
, 2022 CLICK-chemistry has become a universal route to covalently link organic molecules functionalized with azides and alkynes, respectively. Here, we report how CLICK-chemistry can be used to attach oligoaromatic organic moieties to Dawson-type ...
Hänle, Matthias +5 more
core +1 more source