Results 21 to 30 of about 1,276,924 (370)
Molecules, 2021 The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules.
Daniela Perrone +3 more
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Frontiers in Chemistry, 2022 Chemical cross-linking coupled with mass spectrometry has emerged as a powerful strategy which enables global profiling of protein interactome with direct interaction interfaces in complex biological systems.
Lili Zhao +13 more
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Advanced Materials Interfaces, 2023 2D materials have attracted considerable attention in the past decade for their superlative physical properties. Lightweight foam from 2D materials can reduce the use of raw materials, save energy in processing the material and downregulate the carbon ...
Rahul Patil, Saikat Dutta
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Recent Advancements in Triazole-based Click Chemistry in Cancer Drug Discovery and Development
SynOpen, 2023 Triazole-based compounds possess a broad range of activity and can be synthesized using click chemistry. Many new chemotherapeutic agents have been developed in recent years by exploiting click chemistry and these are covered in this review.
Arun Kumar +3 more
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A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids.
Chemical Reviews, 2021 Click chemistry is an immensely powerful technique for the fast and efficient covalent conjugation of molecular entities. Its broad scope has positively impacted on multiple scientific disciplines, and its implementation within the nucleic acid field has
N. Z. Fantoni, A. El-Sagheer, T. Brown
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Click Chemistry in Proteomic Investigations [PDF]
Cell, 2020 Despite advances in genetic and proteomic techniques, a complete portrait of the proteome and its complement of dynamic interactions and modifications remains a lofty, and as of yet, unrealized, objective. Specifically, traditional biological and analytical approaches have not been able to address key questions relating to the interactions of proteins ...
Christopher G. Parker, Matthew R. Pratt
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Heterogeneous Photocatalytic Click Chemistry [PDF]
Journal of the American Chemical Society, 2016 Copper-doped semiconductors are designed to photoassist the alkyne-azide cycloaddition catalysis by Cu(I). Upon irradiation, injection of electrons from the semiconductor into copper oxide nanostructures produces the catalytic Cu(I) species. The new catalysts are air- and moisture-tolerant and can be readily recovered after use and reused several times.
Wang, Bowen +4 more
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Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 [PDF]
, 2011 We describe the use of iterative in situ click chemistry to design an Akt-specific branched peptide triligand that is a drop-in replacement for monoclonal antibodies in multiple biochemical assays.
Agnew, Heather D. +12 more
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In situ click chemistry generation of cyclooxygenase-2 inhibitors
Nature Communications, 2017 Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases.
A. Bhardwaj, J. Kaur, M. Wuest, F. Wuest
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Application of click chemistry in nanoparticle modification and its targeted delivery
Biomaterials Research, 2018 Background Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative ...
Gawon Yi +4 more
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