Results 51 to 60 of about 2,796,861 (304)
The intramolecular click reaction using ‘carbocontiguous’ precursors [PDF]
Tetrahedron, 2017 The synthesis and utilization of all carbon-chain 'carbocontiguous' azidoalkynyl precursors for an intramolecular click reaction is described. The substrates contain both azidoalkyl and ethynylmethyl groups which are conjoined by a 2-(phenylsulfonylmethyl)-4,5-diphenyloxazole lynchpin and are suitably disposed for ring closure.
Pravin C, Patil, Frederick A, Luzzio
openaire +2 more sources
Building Covalent Molecular Capsules by Thiol-Michael Addition Click Reaction
, 2019 The thiol-Michael addition (TMA) is a powerful methodology to click several fragments together, despite having been underestimated in the synthesis of complex systems for supramolecular chemistry.
Romen Carrillo (1306485) +7 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações
Química Nova, 2011 The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily ...
Luiza Baptista de Oliveira Freitas +5 more
doaj +1 more source
Nature Communications, 2023 A carbene-catalyzed asymmetric access to chiral β-cyano carboxylic esters is disclosed. The reaction proceeds between β,β-disubstituted enals and aromatic thiols involving enantioselective protonation of enal β-carbon.
Qingyun Wang +6 more
doaj +1 more source
Molecules, 2021 The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules.
Daniela Perrone +3 more
doaj +1 more source
Synthesis of Click reaction derived imidazoquinoline dendrimer 8.
, 2013 Synthesis of Click reaction derived imidazoquinoline dendrimer 8.
Rajalakshmi Balakrishna (309826) +5 more
core +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Design and synthesis of multivalent neoglycoconjugates by click conjugations
Beilstein Journal of Organic Chemistry, 2014 A highly stereoselective BF3∙OEt2-promoted tandem hydroamination/glycosylation on glycal scaffolds has been developed to form propargyl 3-tosylamino-2,3-dideoxysugars in a one-pot manner.
Feiqing Ding +4 more
doaj +1 more source
Cu-Catalyzed Click Reaction in Carbohydrate Chemistry
, 2016 Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC), popularly known as the "click reaction", serves as the most potent and highly dependable tool for facile construction of simple to complex architectures at the molecular level. Click-knitted
Mishra, Bhuwan B +11 more
core +1 more source