Results 51 to 60 of about 436,100 (303)

Comparative Analysis of Nanoparticle-Antibody Conjugations: Carbodiimide Versus Click Chemistry

Molecular Imaging, 2009
The ability to modify the physical, chemical, and biologic properties of nanoparticles has led to their use as multifunctional platforms for drug delivery and diagnostic imaging applications.
Daniel L.J. Thorek, ew R. Elias, Andrew Tsourkas   +2 more
doaj   +1 more source

Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications

Molecules, 2021
The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules.
Daniela Perrone, Elena Marchesi, Lorenzo Preti, Maria Luisa Navacchia   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release

Nature Communications, 2023
A carbene-catalyzed asymmetric access to chiral β-cyano carboxylic esters is disclosed. The reaction proceeds between β,β-disubstituted enals and aromatic thiols involving enantioselective protonation of enal β-carbon.
Qingyun Wang, Shuquan Wu, Juan Zou, Xuyang Liang, Chengli Mou, Pengcheng Zheng, Yonggui Robin Chi   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Click-Chemistry-Based Free Azide versus Azido Sugar Detection Enables Rapid In Vivo Screening of Glycosynthase Activity

, 2021
Engineering of carbohydrate-active enzymes such as glycosynthases to enable chemoenzymatic synthesis of bespoke oligosaccharides has been limited by the lack of suitable ultrahigh-throughput screening methods capable of robustly detecting either starting
Ayushi Agrawal, Chandra Kanth Bandi, Tucker Burgin, Heather B. Mayes, Chandra Kanth Bandi (11414586), Ayushi Agrawal (10343267), Tucker Burgin (11414589), Youngwoo Woo (11414592), Shishir P. S. Chundawat (7296056), Shishir P. S. Chundawat, Youngwoo Woo, Heather B. Mayes (1332222)   +11 more
core   +1 more source

Development of a Borane–(Meth)acrylate Photo‐Click Reaction [PDF]

, 2021
The development of 3D printing fuels the need for new photoinitiating systems working under mild conditions and/or leading to polymers with new and/or enhanced properties.
Lansalot, Muriel, Rémi Canterel, Guido Pintacuda, Lalevee, J. (Jacques), Muriel Lansalot, Jan Blahut, Bernadette Graff, Céline Dietlin, Jacques Lalevée, Pintacuda, G. (Guido), Blahut, Jan, Dietlin, C. (Celine), Bourgeat-Lami, Elodie, Benda, Ladislav, Ladislav Benda, Aissam Airoudj, Elodie Bourgeat‐Lami, Bourgeat‐Lami, E. (Elodie), Morlet-Savary, Fabrice, Aubry, Berengere, Lacote, Emmanuel, Morlet-Savary, F. (Fabrice), Airoudj, Aissam, Dietlin, Celine, Canterel, R. (Rémi), Airoudj, A. (Aissam), Lansalot, M. (Muriel), Bérengère Aubry, Pintacuda, Guido, Benda, L. (Ladislav), Lacôte, E. (Emmanuel), Lalevee, Jacques, Canterel, Rémi, Aubry, B. (Bérengère), Emmanuel Lacôte, Graff, Bernadette, Blahut, J. (Jan), Fabrice Morlet‐Savary, Graff, B. (Bernadette)   +38 more
core   +1 more source

A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações

Química Nova, 2011
The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily ...
Luiza Baptista de Oliveira Freitas, Fernando Armini Ruela, Guilherme Rocha Pereira, Rosemeire Brondi Alves, Rossimiriam Pereira de Freitas, Leandro José dos Santos   +5 more
doaj   +1 more source

Polymer Nanocomposites via Click Chemistry Reactions [PDF]

Polymers, 2017
The emerging areas of polymer nanocomposites, as some are already in use in industrial applications and daily commodities, have the potential of offering new technologies with all manner of prominent capabilities. The incorporation of nanomaterials into polymeric matrix provides significant improvements, such as higher mechanical, thermal or electrical
Mehmet Arslan, Mehmet Tasdelen
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source