Results 31 to 40 of about 436,100 (303)
Click-Ready Perfluorocarbon Nanoemulsion for 19F MRI and Multimodal Cellular Detection
, 2021 We describe an in vivo imaging probe platform that is readily modifiable to accommodate binding of different molecular targeting moieties and payloads for multimodal image generation.
Eric T. Ahrens +15 more
core +1 more source
Origin of Orthogonality of Strain‐Promoted Click Reactions [PDF]
Chemistry – A European Journal, 2015 AbstractSite‐specific labeling of biomolecules is rapidly advancing due to the discovery of novel mutually orthogonal reactions. Quantum chemistry studies have also increased our understanding of their relative rates, although these have until now been based on highly simplified reactants.
Wagner Johannes A. +4 more
openaire +4 more sources
Biologically targeted probes for Zn2+: a diversity oriented modular “click-SNAr-click” approach [PDF]
, 2014 We describe a one-pot strategy for the high yielding, operationally simple synthesis of fluorescent probes for Zn2+ that bear biological targeting groups and exemplify the utility of our method through the preparation of a small library of sensors ...
Hodson, D.J. +14 more
core +1 more source
Molecular Diffusivity of Click Reaction Components: The Diffusion Enhancement Question
, 2022 Micrometer-sized objects are widely known to exhibit chemically driven motility in systems away from equilibrium. Experimental observation of reaction-induced motility or enhancement in diffusivity at the much shorter length scale of small molecules is ...
Golestanian R. +3 more
core +3 more sources
A dark intermediate in the fluorogenic reaction between tetrazine fluorophores and trans-cyclooctene
Biophysical Reports, 2022 Fluorogenic labeling via bioorthogonal tetrazine chemistry has proven to be highly successful in fluorescence microscopy of living cells. To date, trans-cyclooctene (TCO) and bicyclonyne have been found to be the most useful substrates for live-cell ...
Felix Hild +4 more
doaj +1 more source
Click to learn, learn to click: Undergraduate Synthetic Organic Chemistry experiments
, 2022 The optimization of an undergraduate experiment for Organic Chemistry students is described to explore the concept of click chemistry. The preparation of a terminal fluorescent alkyne and an organic azide is reported consisting of simple steps. These are
Francisco, Santoyo-Gonzalez +3 more
core +1 more source
Pharmaceuticals, 2023 The innovative design of a triarylborane (TB)-dye with one NMe2-alkylated (propargylated) group and one NMe2 group yielded a system that is both an NMe2 π-donor and an inductive NMe2-alkyl cationic acceptor.
Marta Jurković +4 more
doaj +1 more source
Click histochemistry for whole-mount staining of brain structures
MethodsX, 2019 Labeling of the replicating DNA with synthetic thymidine analogs is commonly used for marking the dividing cells. However, until now this method has only been applied to histological sections.
Alexander A. Lazutkin +2 more
doaj +1 more source
Click-to-Chelate: Development of Technetium and Rhenium-Tricarbonyl Labeled Radiopharmaceuticals
Molecules, 2013 The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores.
Thomas L. Mindt, Christiane A. Kluba
doaj +1 more source
Oligonucleotide Conjugation by Tyrosine‐Click Reaction
, 2022 International audienceN,O-diacetyl tyrosine and 3-(4-hydroxy-phenyl)-propanoic acid were converted into phosphoramidite derivatives and introduced to the 5'-end of oligonucleotides.
François Morvan +7 more
core +1 more source