Supramolecular Construction of a Highly Elongated π-Conjugated Structure in the Solid State: Metal-Free Click Reaction Guided by C-H Hydrogen Bonding [PDF]
, 2023 A planned topochemical azide-alkyne cycloaddition is developed in the organic solid state to generate a highly elongated π-conjugated 1,2,3-triazole by a metal-free click reaction.
Amy, Charles +3 more
core +2 more sources
Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition [PDF]
, 2011 A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the ...
Krim, Jamal +5 more
core +1 more source
A simple access to transition metal cyclopropenylidene complexes [PDF]
, 2015 The authors gratefully acknowledge the Royal Society (University Research Fellowship to CSJC) and the DOE (DE-FG02-13ER16370) for financial support.We report the first example of BAC–Cu complex (BAC = bis(diisopropylamino)cyclopropenylidene) and its use ...
Slawin, Alexandra MZ +12 more
core +1 more source
Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’ Strategy: From Bench to Flow [PDF]
Synthesis, 2011 The development of a 'click, click, cy-click' process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a microwave-assisted, continuous flow organic synthesis ...
Zang, Qin +8 more
openaire +3 more sources
From Micro to Marvel: Unleashing the Full Potential of Click Chemistry with Micromachine Integration
MicromachinesMicromachines, small-scale engineered devices prepared to carry out exact tasks at the micro level, have garnered great interest across different fields such as drug delivery, chemical synthesis, and biomedical applications.
Zihan Chen +3 more
doaj +1 more source
Aggregate, 2023 Alkyne‐based click polymerizations have been nurtured into a powerful synthetic technique for the preparation of new polymers with advanced structures and versatile properties.
Xinyao Fu, Anjun Qin, Ben Zhong Tang
doaj +1 more source
X-Yne Click Polymerization [PDF]
, 2022 Alkyne-based click polymerizations have been nurtured into a powerful synthetic technique for the synthesis of new polymers with advanced structures and versatile functionalities.
Ben Zhong, Tang, Xinyao, Fu, Anjun, Qin
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Comparative Analysis of Nanoparticle-Antibody Conjugations: Carbodiimide Versus Click Chemistry
Molecular Imaging, 2009 The ability to modify the physical, chemical, and biologic properties of nanoparticles has led to their use as multifunctional platforms for drug delivery and diagnostic imaging applications.
Daniel L.J. Thorek +2 more
doaj +1 more source
Oligonucleotide Conjugation by Tyrosine‐Click Reaction
, 2022 International audienceN,O-diacetyl tyrosine and 3-(4-hydroxy-phenyl)-propanoic acid were converted into phosphoramidite derivatives and introduced to the 5'-end of oligonucleotides.
François Morvan +7 more
core +1 more source