Results 61 to 70 of about 2,796,861 (304)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Innovative Peptide Bioconjugation Chemistry with Radionuclides: Beyond Classical Click Chemistry
PharmaceuticalsBackground: The incorporation of radionuclides into peptides and larger biomolecules requires efficient and sometimes biorthogonal reaction conditions, to which click chemistry provides a convenient approach.
Samantha Leier, Frank Wuest
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Applications of Click Chemistry in Radiopharmaceutical Development
CHIMIA, 2010 Click chemistry, a concept that employs only practical and reliable transformations for compound synthesis, has made a significant impact in several areas of chemistry, including material sciences and drug discovery.
Joseph C. Walsh, Hartmuth C. Kolb
doaj +1 more source
Improving bioorthogonal protein ubiquitylation by click reaction [PDF]
Bioorganic & Medicinal Chemistry, 2013 Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also non-proteolytic functions by altering the biochemical properties of the modified protein.
Schneider, Daniel +4 more
openaire +3 more sources
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Synthesis and properties of new fluorescent dyes and dye-labelled oligonucleotides
, 2012 Fluorescence is widely used in DNA sequencing and genetic analysis. Novel fluorescence techniques for studying nucleic acids and other biologically important molecules are constantly being developed.
Gerowska, Marta
core +1 more source
Chemosensors, 2023 The functionalization of biosensor interfaces constitutes a crucial aspect of biosensing systems, as it directly governs key characteristics, including sensitivity, selectivity, accuracy, and rapidity.
Feiyu Wang +3 more
doaj +1 more source
One-Pot Synthesis of Polypyrazoles by Click Reactions [PDF]
Scientific Reports, 2017 AbastractWe developed an efficient one-pot metal-free click polymerization procedure for the synthesis of 3,5-disubstituted polypyrazoles with high yields, high molecular weights, and narrow molecular weight distribution. The method involved two click reactions in a one-pot synthesis.
Wang, Shasha, Cheng, Bin
openaire +2 more sources
A new insight into the Biginelli reaction: the dawn of multicomponent click chemistry?
, 2013 Looking at ‘old’ reactions from new perspectives sometimes brings new breakthroughs in current hot research areas. We therefore reinvestigated the successful multicomponent reactions (MCRs) in organic chemistry, and are pleased to find the Biginelli ...
Wei, Yen +5 more
core +1 more source