Results 61 to 70 of about 436,100 (303)
Redox-Click Chemistry for Disulfide Formation from Thiols
, 2023 The dynamic disulfide linkage plays a vital role in various biological processes as well as drugs and biomaterials. Oxidation of thiols is a widely utilized approach for disulfide synthesis; however, achieving both optimal reactivity and selectivity ...
Xiaohe, Zhang +19 more
core +1 more source
Design and synthesis of multivalent neoglycoconjugates by click conjugations
Beilstein Journal of Organic Chemistry, 2014 A highly stereoselective BF3∙OEt2-promoted tandem hydroamination/glycosylation on glycal scaffolds has been developed to form propargyl 3-tosylamino-2,3-dideoxysugars in a one-pot manner.
Feiqing Ding +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Applications of Click Chemistry in Radiopharmaceutical Development
CHIMIA, 2010 Click chemistry, a concept that employs only practical and reliable transformations for compound synthesis, has made a significant impact in several areas of chemistry, including material sciences and drug discovery.
Joseph C. Walsh, Hartmuth C. Kolb
doaj +1 more source
Chemosensors, 2023 The functionalization of biosensor interfaces constitutes a crucial aspect of biosensing systems, as it directly governs key characteristics, including sensitivity, selectivity, accuracy, and rapidity.
Feiyu Wang +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2011 A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the ...
Krim, Jamal +5 more
core +1 more source
Innovative Peptide Bioconjugation Chemistry with Radionuclides: Beyond Classical Click Chemistry
PharmaceuticalsBackground: The incorporation of radionuclides into peptides and larger biomolecules requires efficient and sometimes biorthogonal reaction conditions, to which click chemistry provides a convenient approach.
Samantha Leier, Frank Wuest
doaj +1 more source
Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications
SynOpen, 2023 This short review describes the assistance of click chemistry in the chemical modification of glycosaminoglycans. Through an alkyne-azide 1,3-dipolar cycloaddition reaction, the chemically and physiologically stable triazole unit connects ...
Smritilekha Bera, Dhananjoy Mondal
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source