Results 71 to 80 of about 436,100 (303)

Improving bioorthogonal protein ubiquitylation by click reaction [PDF]

Bioorganic & Medicinal Chemistry, 2013
Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also non-proteolytic functions by altering the biochemical properties of the modified protein.
Schneider, Daniel, Schneider, Tatjana, Rösner, Daniel, Scheffner, Martin, Marx, Andreas   +4 more
openaire   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Click reactions in chitosan chemistry

Russian Chemical Bulletin, 2017
The review provides the first generalized and systematized information on the use of click reactions in chitosan chemistry for the preparation of novel polymers with attractive physicochemical and biological properties. The reactions of copper-catalyzed azide—alkyne cycloaddition and the click reactions of chitosan derivatives occurring in the absence ...
Kritchenkov A.S., Skorik Y.A.
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A simple access to transition metal cyclopropenylidene complexes

, 2015
The authors gratefully acknowledge the Royal Society (University Research Fellowship to CSJC) and the DOE (DE-FG02-13ER16370) for financial support.We report the first example of BAC–Cu complex (BAC = bis(diisopropylamino)cyclopropenylidene) and its use ...
Slawin, Alexandra MZ, Bertrand , Guy, Cazin, Catherine S.J., Cordes, David B, Bidal, Yannick Daniel, Cordes, David Bradford, Cazin, Catherine, Slawin, Alexandra Martha Zoya, Bidal, Yannick D, Cazin, CatherineWE060001614845868020023665330000-0002-9094-8131A857376E-5833-11E6-A7EF-CE99B5D1D7B1, Bertrand, Guy, Lesieur, Mathieu, Melaimi, Mohand   +12 more
core   +1 more source

Superstructures of fluorescent cyclodextrin via click-reaction

Beilstein Journal of Organic Chemistry, 2013
Mono-(6-azido-6-deoxy)-β-cyclodextrin (CD) was covalently attached to an alkyne-modified 5-methyl-2-(pyridin-2-yl)thiazol-4-ol yielding a fluorophore containing CD in a click-type reaction.
Arkadius Maciollek, Helmut Ritter, Rainer Beckert   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Mild Covalent Functionalization of Transition Metal Dichalcogenides with Maleimides: A “Click” Reaction for TMDCs

, 2018
The physical properties of ultrathin transition metal dichalcogenides (2D-TMDCs) make them promising candidates as active nanomaterials for catalysis, optoelectronics, and biomedical applications.
Mariano, Vera-Hidalgo, Emerson, Giovanelli, Emilio, Pérez, Cristina, Navío   +3 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry

Beilstein Journal of Organic Chemistry, 2015
The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles.
Zhan-Jiang Zheng, Ding Wang, Zheng Xu, Li-Wen Xu   +3 more
doaj   +1 more source