Results 71 to 80 of about 597,976 (301)

Acetoacetate based thermosets prepared by dual-Michael addition reactions [PDF]

, 2019
A novel set of dual-curable multiacetoacetate-multiacrylate-divinyl sulfone ternary materials with versatile and manipulable properties are presented.
Fernández Francos, Xavier, Konuray, Ali Osman, Ramis Juan, Xavier, Serra Albet, Maria Àngels   +3 more
core   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Sequential curing of amine-acrylate-methacrylate mixtures based on selective aza-Michael addition followed by radical photopolymerization [PDF]

, 2016
Dual curing systems find various uses in industry with the process flexibility they provide which allows tailoring properties at different curing stages in accordance with application requirements. A safe and efficient dual curing scheme is proposed here
Fernández Francos, Xavier, Konuray, Ali Osman, Ramis Juan, Xavier, Serra Albet, Àngels   +3 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Mechanisms of goethite dissolution in the presence of desferrioxamine B and Suwannee River fulvic acid at pH 6.5 [PDF]

, 2013
Siderophores are Fe3+ specific low MW chelating ligands secreted by microorganisms in response to Fe stress. Low MW organic acids such as oxalate have been shown to enhance siderophore mediated dissolution of Fe3+ oxides.
Alvarez-Puebla, Angela G. Stewart, Borer, Brantley, Carrasco, Cervini-Silva, Cheah, Chin, Cocozza, Colnaghi Simionato, Cornell, Cornell, Cozar, Cramer, Dhungana, Domagal-Goldman, Dubbin, Edwards, Filius, Filius, Fu, Gan, Ghabbour, Haselwandter, Hay, Holmén, Holmén, Karen A. Hudson-Edwards, Kosmulski, Kraemer, Kraemer, Lasaga, Liermann, Nightingale, Pandeya, Powell, Prasad, Qu, Raymond, Reichard, Reichard, Ritchie, Schindler, Schwertmann, Sharma, Siebner-Freibach, Simanova, Sposito, Sposito, Stevenson, Stumm, Tatár, Tipping, Watteau, Weng, Weng, Whitnall, William E. Dubbin   +57 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Application of Droplet-Array Sandwiching Technology to Click Reactions for High-Throughput Screening

Micromachines
High-throughput screening (HTS) is an essential process in drug discovery, requiring platforms that ensure reagent economy, high efficiency, and resistance to cross-contamination.
Yoshinori Miyata, Shoma Nishimura, Sora Kawakami, Yuriko Higuchi, Satoshi Konishi   +4 more
doaj   +1 more source

Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry

Beilstein Journal of Organic Chemistry, 2015
The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles.
Zhan-Jiang Zheng, Ding Wang, Zheng Xu, Li-Wen Xu   +3 more
doaj   +1 more source

Acid-Labile Traceless Click Linker for Protein Transduction [PDF]

, 2012
Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of ...
Bachelder E. M., Dohmen C., Engin K., Ernst Wagner, Frohlich T., Kevin Maier, Lee Y., Meyer M., Meyer M., Meyer M., Miyata K., Murphy R. F., Murthy N., Nieto M. A., Rozema D. B., Rozema D. B., Saxon E., Schaffert D., Vallee M. R., Wagner E., Wagner E., Yu H.   +21 more
core   +1 more source