Results 81 to 90 of about 2,796,861 (304)

Click-to-Release for Controlled Immune Cell Activation: Tumor-Targeted Unmasking of an IL12 Prodrug

Pharmaceuticals
Objectives: Immunotherapy utilizing immune-stimulating cytokines such as IL12 holds great promise for the treatment of cancer. However, clinical use of IL12 is hampered due to severe toxicity following systemic administration.
Martijn H. den Brok, Kim E. de Roode, Luc H. M. Zijlmans, Laurens H. J. Kleijn, Marleen H. M. E. van Stevendaal, Ron M. Versteegen, Lieke W. M. Wouters, Raffaella Rossin, Marc S. Robillard   +8 more
doaj   +1 more source

Organobase-Catalyzed Hydroxyl-yne Click Polymerization [PDF]

, 2019
The proposition of click chemistry has provided a quick channel for saccharides modification, which has always been worth exploring. Click reaction of hydroxyl groups possessed by saccharides is thus highly desirable to be developed.
Ben Zhong, Tang, Han, Si, Kaojin, Wang, Bo, Song, Anjun, Qin   +4 more
core   +2 more sources

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry

Beilstein Journal of Organic Chemistry, 2015
The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles.
Zhan-Jiang Zheng, Ding Wang, Zheng Xu, Li-Wen Xu   +3 more
doaj   +1 more source

Nanoparticles under the light: click functionalization by photochemical thiol-yne reaction, towards double click functionalization.

, 2013
International audienceA light click away: The first application of the thiol-yne reaction to nanoparticle functionalization is described (see figure). This metal-free click chemistry approach is compatible with the addition of various molecules at the ...
Hardouin, Julie, Guénin, Erwann, Motte, Laurence, Hardouin, J., Guénin, E., Motte, L., Nehlig, Emilie, Demay-Drouhard, Paul, Demay Drouhard, P., Nehlig, E.   +9 more
core   +1 more source

Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications

Scientific Reports, 2017
Summary The coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra.
Nazir Ahmad, Hussein A. Younus, Adeel H. Chughtai, Kristof Van Hecke, Muhammad Danish, Zhang Gaoke, Francis Verpoort   +6 more
doaj   +1 more source

Advancements and applications of click chemistry in protein labeling and bioconjugation [PDF]

RSC Advances
Click chemistry has emerged as a versatile and efficient chemical strategy for constructing complex molecules under mild conditions. Its core reaction is copper(i)-catalyzed azide–alkyne cycloaddition (CuAAC), which provides high yields ...
Usman Nazeer, Guoting Qin, Chengzhi Cai
doaj   +1 more source

Synthesis and application of some novel functional polymers via controlled radical polymerization and click chemistry [PDF]

The objective of this thesis was to prepare thermoresponsive PEG-based homopolymers and copolymers by combination of cobalt-mediated catalytic chain-transfer polymerization (CCTP) and thiol-ene “click” chemistry and prepare well-defined glycopolymers ...
Li, Guang-Zhao
core  

Real‐World Effectiveness and Safety of Secukinumab in Giant Cell Arteritis: An Italian Multicenter Cohort Study

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to evaluate the real‐world effectiveness and safety of secukinumab in patients with giant cell arteritis (GCA). Methods This multicenter retrospective study included patients with GCA who received secukinumab at 14 Italian centers with at least six months of follow‐up.
Luca Iorio, Federica Davanzo, Caterina Ricordi, Milena Bond, Ruggiero Mascolo, Jacopo Mora, Alessandro Tomelleri, Angelo Fassio, Francesca Cuzzocrea, Sara Monti, Edoardo Conticini, Fabiola Atzeni, Paolo Delvino, Carlotta Nannini, Augusta Ortolan, Francesco Pollastri, Ester Vivaldelli, Chiara Marvisi, Paola Toniati, Antonio Brucato, Alessandra Milanesi, Francesca Regola, Enrico Tombetti, Lorenzo Dagna, Roberta Ramonda, Christian Dejaco, Luca Quartuccio, Carlo Salvarani, Roberto Padoan   +28 more
wiley   +1 more source

Mechano-Induced Synthesis of Polyethylene Glycols α,ω-DiSubstituted with 4-(PAH)-1H-1,2,3-Triazoles in Presence of In Situ-Generated Bronze Microparticles as Catalyst

Molecules
A method for the mechanochemical CuAAC click reaction (Cu+-promoted azido–alkyne cycloaddition) in the presence of bronze powder/copper beads without the use of a pre-introduced catalyst and ligands with greener prospect is presented. A new type of tri-,
Mohammed S. Mohammed, Igor S. Kovalev, Vadim A. Platonov, Sougata Santra, Zhuo Wang, Grigory V. Zyryanov, Valery N. Charushin   +6 more
doaj   +1 more source