Results 81 to 90 of about 595,530 (229)

Synthetic utility and reactivity of N-alkynylazoles [PDF]

, 2015
textThe chemistry of N-alkynylazoles is a newly emerging area of chemistry with particular interest in heterocycle synthesis. Synthetic preparations of this class of molecule have shown an increasing presence in literature, however, the synthetic ...
Gilbreath, Bradford Lynd
core  

Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway. [PDF]

, 2008
BACKGROUND: Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation and selection by "in silico" experimentation.
A Herrmann, A Mahdavi, A Regev, A Regev, A Singh, A Verma, AD Sharrocks, Anna Dudka, B Alberts, C Priami, C Priami, Corrado Priami, D Gillespie, F Ciocchetta, I Lödige, I Swameye, J Bravo, J Fisher, J Heath, J ten Hoeve, John K Heath, K Rakesh, L Dematté, L Dematté, L Klampfer, M Calder, M Kwiatkowska, Maria Luisa Guerriero, ML Guerriero, ML Guerriero, ML Guerriero, N Underhill-Day, NC Reich, Nicholas Underhill-Day, P Heinrich, S Bhattacharya, T Yamamoto, WS Alexander   +37 more
core   +6 more sources

Click-to-Release for Controlled Immune Cell Activation: Tumor-Targeted Unmasking of an IL12 Prodrug

Pharmaceuticals
Objectives: Immunotherapy utilizing immune-stimulating cytokines such as IL12 holds great promise for the treatment of cancer. However, clinical use of IL12 is hampered due to severe toxicity following systemic administration.
Martijn H. den Brok, Kim E. de Roode, Luc H. M. Zijlmans, Laurens H. J. Kleijn, Marleen H. M. E. van Stevendaal, Ron M. Versteegen, Lieke W. M. Wouters, Raffaella Rossin, Marc S. Robillard   +8 more
doaj   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

A new xantphos-type ligand and its gold(I) complexes: Synthesis, structure, luminescence [PDF]

, 2013
A novel xantphos analog diphosphine ligand, 9,9-dimethyl-4,5-bis(diphenylphosphinomethyl)-9H-xanthene (X(CP)2), with methylene groups inserted between the xanthene skeleton and the two diphenylphosphine units, has been synthesized. A two-coordinate and a
Baranyai, Péter, Besenyei, Gábor, Bitter, István, Faigl, Ferenc, Grün, Alajos, Kubinyi, Miklós, Kunsági-Máté, Éva, Párkányi, László, Szalontai, Gábor   +8 more
core   +1 more source

Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment

EngMedicine
With their high drug-loading capacity and enhanced permeability and retention (EPR) effects, nanoparticles possess significant potential for the diagnosis and treatment of tumors.
Yun Yin, Xiaoyang Liu, Xuemei Li, Gaolin Liang   +3 more
doaj   +1 more source

Synthesis of Novel N-Heterocyclic Compounds Containing 1,2,3-Triazole Ring System via Domino, “Click” and RDA Reactions

Molecules, 2019
An uncomplicated, high-yielding synthetic route has been developed to constitute complicated heterocycles, applying domino, click and retro-Diels⁻Alder (RDA) reaction sequences.
Márta Palkó, Mohamed El Haimer, Zsanett Kormányos, Ferenc Fülöp   +3 more
doaj   +1 more source

CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview

Beilstein Journal of Organic Chemistry, 2023
Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of
Dileep Kumar Singh
doaj   +1 more source

Straightforward synthesis of functionalized cyclic polymers in high yield via RAFT and thiolactone-disulfide chemistry [PDF]

, 2013
An efficient synthetic pathway toward cyclic polymers based on the combination of thiolactone and disulfide chemistry has been developed. First, heterotelechelic linear polystyrene (PS) containing an alpha-thiolactone (TLa) and an omega-dithiobenzoate ...
Baba, Eisuke, Du Prez, Filip, Espeel, Pieter, Stamenović, Milan M., Tezuka, Yasuyuki, Yamamoto, Takuya   +5 more
core   +1 more source

Cyclooctyne-based reagents for uncatalyzed click chemistry: A computational survey [PDF]

, 2009
With the goal of identifying alkyne-like reagents for use in click chemistry, but without Cu catalysts, we used B3LYP density function theory (DFT) to investigate the trends in activation barriers for the 1,3-dipolar cycloadditions of azides with various
Chenoweth, David, Chenoweth, Kimberly, Goddard, William A. III   +2 more
core   +1 more source