Results 81 to 90 of about 5,177,092 (374)

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Core-Clickable PEG-Branch-Azide Bivalent-Bottle-Brush Polymers by ROMP: Grafting-Through and Clicking-To [PDF]

, 2011
The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic tructures.
Burts, Alan O., Finn, M. G., Grubbs, Robert H., Johnson, Jeremiah A., Koberstein, Jeffrey T., Lim, Yeon-Hee, Lu, Ying Y., Tirrell, David A., Turro, Nicholas J.   +8 more
core   +2 more sources

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S, Chester, KA, Chudasama, V, Maruani, A, Miranda, E, Smith, ME   +5 more
core   +1 more source

Advancing Electronic Application of Coordination Solids: Enhancing Electron Transport and Device Integration via Surface‐Mounted MOFs (SURMOFs)

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of coordination solids, enabled by the surface‐mounted metal‐organic framework (SURMOF) platform, is on the cusp of generating the organic counterpart of the epitaxy of inorganics. The programmable and sequential SURMOF protocol, optimized by machine learning (ML), is suited for accessing high‐quality thin films of ...
Zhengtao Xu, Christof Wöll, Stefan Bräse   +2 more
wiley   +1 more source

Application of Droplet-Array Sandwiching Technology to Click Reactions for High-Throughput Screening

Micromachines
High-throughput screening (HTS) is an essential process in drug discovery, requiring platforms that ensure reagent economy, high efficiency, and resistance to cross-contamination.
Yoshinori Miyata, Shoma Nishimura, Sora Kawakami, Yuriko Higuchi, Satoshi Konishi   +4 more
doaj   +1 more source

Poly(thioether) vitrimers via transalkylation of trialkylsulfonium salts [PDF]

, 2017
Vitrimers are permanently cross-linked organic polymers that can be reshaped, molded, and recycled without loss of network integrity. Herein, we report poly(thioether) networks, prepared through a straightforward thiol-ene photopolymerization, that can ...
Hendriks, Benjamin, Waelkens, Jelle, Winne, Johan, Du Prez, Filip   +3 more
core   +1 more source

High‐Concentration Mesogen‐Assisted Exfoliation of Low‐Dimensional Nanomaterials for Achieving Ultralow‐Temperature Actuations of Liquid Crystal Elastomers

Advanced Functional Materials, EarlyView.
Most matter is nominally frozen in the polar regions or space, and liquid crystal materials are no exception. Consequently, soft actuators, including liquid crystal elastomers (LCEs), are inoperative under such extreme cold in response to stimuli, as their motion relies on mechanical deformation.
Hyeonseong Kim, Yeon Gyeong Ha, Dong‐Gue Kang, Chinedum O. Osuji, Dae Seok Kim, Changyeon Lee   +5 more
wiley   +1 more source

Click-to-Release for Controlled Immune Cell Activation: Tumor-Targeted Unmasking of an IL12 Prodrug

Pharmaceuticals
Objectives: Immunotherapy utilizing immune-stimulating cytokines such as IL12 holds great promise for the treatment of cancer. However, clinical use of IL12 is hampered due to severe toxicity following systemic administration.
Martijn H. den Brok, Kim E. de Roode, Luc H. M. Zijlmans, Laurens H. J. Kleijn, Marleen H. M. E. van Stevendaal, Ron M. Versteegen, Lieke W. M. Wouters, Raffaella Rossin, Marc S. Robillard   +8 more
doaj   +1 more source

Synthesis of bi- and bis-1,2,3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry

Beilstein Journal of Organic Chemistry, 2015
The Cu(I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has become a useful tool for the facile formation of 1,2,3-triazoles.
Zhan-Jiang Zheng, Ding Wang, Zheng Xu, Li-Wen Xu   +3 more
doaj   +1 more source